Lassa fever causes: Difference between revisions
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==Overview== | ==Overview== | ||
Lassa fever is caused by the ''Lassa virus'', a member of the [[Arenaviridae]] family; it is an [[enveloped virus|enveloped]], single-stranded, bisegmented [[RNA]] virus. [[Replication]] for Lassa virus is very rapid, while also demonstrating temporal control in replication. There are two [[genome]] segments. The first step involved is making [[messenger RNA|mRNA]] copies of the | Lassa fever is caused by the ''Lassa virus'', a member of the [[Arenaviridae]] family; it is an [[enveloped virus|enveloped]], single-stranded, bisegmented [[RNA]] virus. [[viral replication|Replication]] for Lassa virus is very rapid, while also demonstrating temporal control in replication. There are two [[genome]] segments. The first step involved is making [[messenger RNA|mRNA]] copies of the negative-sense [[genome]]. This ensures that there are adequate [[protein]]s, which are required for [[replication]]. The N and L proteins are made from the mRNA produced. The -ve sense genome then makes vcRNA (viral circular RNA) copies of itself which are positive-sense. The vcRNA is a [[template strand|template]] for producing -ve sense progeny but mRNA is also synthesized from it. The mRNA synthesized from vcRNA [[translation (biology)|translates]] the [[G proteins|G (spike) proteins]] and Z proteins. Thus, with this temporal control, the spike proteins are produced last, making the infection further undetected by the [[host (biology)|host]] [[immune system]]. | ||
==References== | ==References== | ||
Revision as of 17:17, 27 December 2012
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Lassa fever Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
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Lassa fever causes On the Web |
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American Roentgen Ray Society Images of Lassa fever causes |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
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Overview
Lassa fever is caused by the Lassa virus, a member of the Arenaviridae family; it is an enveloped, single-stranded, bisegmented RNA virus. Replication for Lassa virus is very rapid, while also demonstrating temporal control in replication. There are two genome segments. The first step involved is making mRNA copies of the negative-sense genome. This ensures that there are adequate proteins, which are required for replication. The N and L proteins are made from the mRNA produced. The -ve sense genome then makes vcRNA (viral circular RNA) copies of itself which are positive-sense. The vcRNA is a template for producing -ve sense progeny but mRNA is also synthesized from it. The mRNA synthesized from vcRNA translates the G (spike) proteins and Z proteins. Thus, with this temporal control, the spike proteins are produced last, making the infection further undetected by the host immune system.