Japanese encephalitis laboratory findings: Difference between revisions
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==Overview== | ==Overview== | ||
Diagnosis is based on a combination of clinical signs and symptoms and specialized laboratory tests of blood or [[cerebrospinal fluid]]. It is diagnosed by detection of antibodies in serum and CSF (cerebrospinal fluid) by IgM capture [[ELISA]]. Clinical laboratory findings might include a moderate leukocytosis, mild anemia, and hyponatremia. Cerebrospinal fluid (CSF) typically has a mild to moderate pleocytosis with a lymphocytic predominance, slightly elevated protein, and normal ratio of CSF to plasma glucose. | Diagnosis is based on a combination of clinical signs and symptoms and specialized laboratory tests of blood or [[cerebrospinal fluid]]. It is diagnosed by detection of antibodies in serum and CSF (cerebrospinal fluid) by IgM capture [[ELISA]]. Clinical laboratory findings might include a moderate leukocytosis, mild anemia, and hyponatremia. Cerebrospinal fluid (CSF) typically has a mild to moderate pleocytosis with a lymphocytic predominance, slightly elevated protein, and normal ratio of CSF to plasma glucose. Because humans have low or undetectable levels of viremia by the time distinctive clinical symptoms are recognized, virus isolation and nucleic acid amplification tests are insensitive and should not be used for ruling out a diagnosis of JE. | ||
==References== | ==References== | ||
Revision as of 18:46, 27 December 2012
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Japanese encephalitis Microchapters |
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Japanese encephalitis laboratory findings On the Web |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
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Overview
Diagnosis is based on a combination of clinical signs and symptoms and specialized laboratory tests of blood or cerebrospinal fluid. It is diagnosed by detection of antibodies in serum and CSF (cerebrospinal fluid) by IgM capture ELISA. Clinical laboratory findings might include a moderate leukocytosis, mild anemia, and hyponatremia. Cerebrospinal fluid (CSF) typically has a mild to moderate pleocytosis with a lymphocytic predominance, slightly elevated protein, and normal ratio of CSF to plasma glucose. Because humans have low or undetectable levels of viremia by the time distinctive clinical symptoms are recognized, virus isolation and nucleic acid amplification tests are insensitive and should not be used for ruling out a diagnosis of JE.