Dilated cardiomyopathy laboratory findings: Difference between revisions
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{{Dilated cardiomyopathy}} | {{Dilated cardiomyopathy}} | ||
Most of the laboratory workup for dilated cardiomyopathy is usually targeted towards detecting the cause.<ref name="pmid27339497">{{cite journal| author=Japp AG, Gulati A, Cook SA, Cowie MR, Prasad SK| title=The Diagnosis and Evaluation of Dilated Cardiomyopathy. | journal=J Am Coll Cardiol | year= 2016 | volume= 67 | issue= 25 | pages= 2996-3010 | pmid=27339497 | doi=10.1016/j.jacc.2016.03.590 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27339497 }}</ref> | |||
* [[Thyroid function tests]] | |||
* Comprehensive metabolic panel | |||
* Workup for [[anemia]] ([[Complete blood count|CBC]] and iron studies) | |||
* Urine toxicology screening | |||
** Some drugs as [[cocaine]] and [[amphetamine]] increase the risk of [[dilated cardiomyopathy]] | |||
* [[Genetic testing|Genetic screening]] | |||
** Usually reserved as the last step. | |||
** May identify genetic/inherited causes of dilated cardiomyopathy. | |||
Other laboratory investigations may target the severity of the condition or its effect on the cardiac function. | |||
* Cardiac biomarkers ([[troponin]] and [[Creatine kinase|CK-MB]]) | |||
* [[Brain natriuretic peptide]] (BNP) | |||
Other biomarkers currently under investigation include: | |||
* [[Uric acid]] (persistently elevated) | |||
* [[Osteopontin]] | |||
* Ca-125 | |||
* Pro-inflammatory [[Cytokine|cytokines]] (as [[Tumour necrosis factor|tumor necrosis factor]]-α and [[Interleukin 6|interleukin-6]])<ref name="pmid18698552">{{cite journal| author=Bielecka-Dabrowa A, Wierzbicka M, Dabrowa M, Goch A| title=New methods in laboratory diagnostics of dilated cardiomyopathy. | journal=Cardiol J | year= 2008 | volume= 15 | issue= 4 | pages= 388-95 | pmid=18698552 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18698552 }}</ref> | |||
==References== | ==References== | ||
Revision as of 15:15, 2 December 2019
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Most of the laboratory workup for dilated cardiomyopathy is usually targeted towards detecting the cause.[1]
- Thyroid function tests
- Comprehensive metabolic panel
- Workup for anemia (CBC and iron studies)
- Urine toxicology screening
- Some drugs as cocaine and amphetamine increase the risk of dilated cardiomyopathy
- Genetic screening
- Usually reserved as the last step.
- May identify genetic/inherited causes of dilated cardiomyopathy.
Other laboratory investigations may target the severity of the condition or its effect on the cardiac function.
- Cardiac biomarkers (troponin and CK-MB)
- Brain natriuretic peptide (BNP)
Other biomarkers currently under investigation include:
- Uric acid (persistently elevated)
- Osteopontin
- Ca-125
- Pro-inflammatory cytokines (as tumor necrosis factor-α and interleukin-6)[2]
References
- ↑ Japp AG, Gulati A, Cook SA, Cowie MR, Prasad SK (2016). "The Diagnosis and Evaluation of Dilated Cardiomyopathy". J Am Coll Cardiol. 67 (25): 2996–3010. doi:10.1016/j.jacc.2016.03.590. PMID 27339497.
- ↑ Bielecka-Dabrowa A, Wierzbicka M, Dabrowa M, Goch A (2008). "New methods in laboratory diagnostics of dilated cardiomyopathy". Cardiol J. 15 (4): 388–95. PMID 18698552.