Pacemaker syndrome differential diagnosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Raviteja Guddeti, M.B.B.S. [2]

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Differentiating Pacemaker syndrome from other Diseases

Patients with pacemaker syndrome present with varied symptoms resulting from dyssynchrony between atria and ventricles. Major presenting symptoms include:

• Dyspnea

• Edema

• Symptoms of low cardiac output like weakness, fatigue, lightheadedness and dyspnea on exertion

Pacemaker syndrome should be differentiated from the following diseases:

• Acute coronary syndrome

• Failed pacemaker

• Hypothyroidism

• Cardiogenic pulmonary edema

• Arrhythmias (especially supraventricular tachycardias)

• Hyperthyroidism

• Pulmonary embolism

• Carotid sinus hypersensitivity

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