Pancreatitis pathophysiology: Difference between revisions
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Revision as of 03:37, 20 February 2013
Pancreatitis Main Page |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Pathophysiology
Genetics
Hereditary pancreatitis may be due to a genetic abnormality that renders trypsinogen active within the pancreas, which in turn leads to digestion of the pancreas from the inside.
Pancreatic diseases are notoriously complex disorders resulting from the interaction of multiple genetic, environmental and metabolic factors. Three candidates for genetic testing are currently under investigation: Trypsinogen mutations, Cystic Fibrosis Transmembrane Conductance Regulator Gene (CFTR) mutations and SPINK1 which codes for PSTI - a specific trypsin inhibitor.[1]
References
- ↑ D. Whitcomb (2006). "Genetic Testing for Pancreatitis".