Bronchiectasis pathophysiology: Difference between revisions
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==Pathophysiology== | ==Pathophysiology== | ||
Dilation of the bronchial walls results in airflow obstruction and impaired clearance of secretions because the dilated areas interrupt normal air pressure of the bronchial tubes, causing [[sputum]] to pool inside the dilated areas instead of being pushed upward.<ref>{{cite journal |author=Morrissey BM |title=Pathogenesis of bronchiectasis |language=English |journal=Clin Chest Med|volume=28 |issue=2 |pages=289-96 |year=2007 |pmid=17467548 |doi=}}</ref> The pooled [[sputum]] provides an environment conducive to the growth of infectious [[pathogen|pathogens]], | *Dilation of the bronchial walls results in airflow obstruction and impaired clearance of secretions because the dilated areas interrupt normal air pressure of the bronchial tubes, causing [[sputum]] to pool inside the dilated areas instead of being pushed upward.<ref>{{cite journal |author=Morrissey BM |title=Pathogenesis of bronchiectasis |language=English |journal=Clin Chest Med|volume=28 |issue=2 |pages=289-96 |year=2007 |pmid=17467548 |doi=}}</ref> | ||
*The pooled [[sputum]] provides an environment conducive to the growth of infectious [[pathogen|pathogens]]. Therefore, that particular area is vulnerable to infections. | |||
*The more infections that the lungs experience, the more damaged the lung tissue and [[alveoli]] become. | |||
*With more damage to the lung tissue, the [[bronchial tube]]s become more inelastic and dilated. This creates a perpetual, destructive cycle within this disease. | |||
There are three types of bronchiectasis, varying by level of severity. Fusiform (cylindrical) bronchiectasis (the most common type) refers to mildly inflamed [[bronchi]] that fail to taper distally. In varicose bronchiectasis, the bronchial walls appear beaded, because areas of dilation are mixed with areas of constriction. Saccular (cystic) bronchiectasis is characterized by severe, irreversible ballooning of the bronchi peripherally, with or without air-fluid levels.<ref>{{cite journal |author=Mysliwiec, V, Pina, JS |title=Bronchiectasis: the 'other' obstructive lung disease |language=English |journal=POSTGRADUATE MEDICINE |volume=106 |issue=1 |pages=252-63 |year=1999 |pmid= |doi=}}</ref> Chronic productive cough is prominent, occurring in up to 90% of patients with bronchiectasis. Sputum is produced on a daily basis in 76% of patients. | There are three types of bronchiectasis, varying by level of severity. Fusiform (cylindrical) bronchiectasis (the most common type) refers to mildly inflamed [[bronchi]] that fail to taper distally. In varicose bronchiectasis, the bronchial walls appear beaded, because areas of dilation are mixed with areas of constriction. Saccular (cystic) bronchiectasis is characterized by severe, irreversible ballooning of the bronchi peripherally, with or without air-fluid levels.<ref>{{cite journal |author=Mysliwiec, V, Pina, JS |title=Bronchiectasis: the 'other' obstructive lung disease |language=English |journal=POSTGRADUATE MEDICINE |volume=106 |issue=1 |pages=252-63 |year=1999 |pmid= |doi=}}</ref> Chronic productive cough is prominent, occurring in up to 90% of patients with bronchiectasis. Sputum is produced on a daily basis in 76% of patients. | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Bronchiectasis involves bronchi that are dilated, inflamed, and easily collapsible. This results in airflow obstruction and impaired clearance of secretions.
Pathophysiology
- Dilation of the bronchial walls results in airflow obstruction and impaired clearance of secretions because the dilated areas interrupt normal air pressure of the bronchial tubes, causing sputum to pool inside the dilated areas instead of being pushed upward.[1]
- The pooled sputum provides an environment conducive to the growth of infectious pathogens. Therefore, that particular area is vulnerable to infections.
- The more infections that the lungs experience, the more damaged the lung tissue and alveoli become.
- With more damage to the lung tissue, the bronchial tubes become more inelastic and dilated. This creates a perpetual, destructive cycle within this disease.
There are three types of bronchiectasis, varying by level of severity. Fusiform (cylindrical) bronchiectasis (the most common type) refers to mildly inflamed bronchi that fail to taper distally. In varicose bronchiectasis, the bronchial walls appear beaded, because areas of dilation are mixed with areas of constriction. Saccular (cystic) bronchiectasis is characterized by severe, irreversible ballooning of the bronchi peripherally, with or without air-fluid levels.[2] Chronic productive cough is prominent, occurring in up to 90% of patients with bronchiectasis. Sputum is produced on a daily basis in 76% of patients.