Meningococcemia classification: Difference between revisions
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{{CMG}}; '''Associate Editor(s)-in-Chief:''' {{CZ}} | {{CMG}}; '''Associate Editor(s)-in-Chief:''' {{CZ}} | ||
==Overview== | |||
==Classification== | ==Classification== | ||
*Meningococci are classified by using serologic methods based on the structure of the polysaccharide capsule. | |||
* | |||
* 13 Serotypes are described based on capsular polysaccharide: A, B, C, D, X, Y, Z, E, W-135, H, I, K, and L. | * 13 Serotypes are described based on capsular polysaccharide: A, B, C, D, X, Y, Z, E, W-135, H, I, K, and L. | ||
* Serogroup A usually with epidemics in less developed nations and an attack rate of as high as 500 cases per 100,000 population. | * Serogroup A usually with epidemics in less developed nations and an attack rate of as high as 500 cases per 100,000 population. | ||
* Serogroup B usually in developed nations with attack rate of 50-100 cases per 100,000 population. | * Serogroup B usually in developed nations with attack rate of 50-100 cases per 100,000 population. | ||
* Serogroup C usually in both developed and less developed populations and an attack rate of up to 500 per 100,000 population. | * Serogroup C usually in both developed and less developed populations and an attack rate of up to 500 per 100,000 population. | ||
*Some strains, often those found to cause asymptomatic nasopharyngeal carriage, are not groupable and do not have a capsule. | |||
*Almost all invasive disease is caused by one of five serogroups: A, B, C, Y, and W-135. | |||
*The relative importance of each serogroup depends on geographic location, as well as other factors, such as age. For instance, serogroup A is a major cause of disease in sub-Saharan Africa but is rarely isolated in the United States. | |||
*Meningococci are further classified on the basis of certain outer membrane proteins. Molecular subtyping using specialized laboratory techniques (e.g., pulsed-field gel electrophoresis) can provide useful epidemiologic information.<ref name=CDC>{{cite web | title = The Centers for Disease Control and Prevention(CDC)| url =http://www.cdc.gov/vaccines/pubs/pinkbook/downloads/mening.pdf}}</ref> | |||
==References== | ==References== | ||
Revision as of 14:35, 20 November 2014
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Meningococcemia Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
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Meningococcemia classification On the Web |
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American Roentgen Ray Society Images of Meningococcemia classification |
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Risk calculators and risk factors for Meningococcemia classification |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Cafer Zorkun, M.D., Ph.D. [2]
Overview
Classification
- Meningococci are classified by using serologic methods based on the structure of the polysaccharide capsule.
- 13 Serotypes are described based on capsular polysaccharide: A, B, C, D, X, Y, Z, E, W-135, H, I, K, and L.
- Serogroup A usually with epidemics in less developed nations and an attack rate of as high as 500 cases per 100,000 population.
- Serogroup B usually in developed nations with attack rate of 50-100 cases per 100,000 population.
- Serogroup C usually in both developed and less developed populations and an attack rate of up to 500 per 100,000 population.
- Some strains, often those found to cause asymptomatic nasopharyngeal carriage, are not groupable and do not have a capsule.
- Almost all invasive disease is caused by one of five serogroups: A, B, C, Y, and W-135.
- The relative importance of each serogroup depends on geographic location, as well as other factors, such as age. For instance, serogroup A is a major cause of disease in sub-Saharan Africa but is rarely isolated in the United States.
- Meningococci are further classified on the basis of certain outer membrane proteins. Molecular subtyping using specialized laboratory techniques (e.g., pulsed-field gel electrophoresis) can provide useful epidemiologic information.[1]