Hurler syndrome surgery: Difference between revisions
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[[Bone marrow transplantation]] (BMT) and [[umbilical cord blood transplantation]] (UCBT) can successfully treat the mucopolysaccharidoses. Abnormal physical characteristics, except for those affecting the skeleton and eyes, can be improved, and neurologic degeneration can often be halted. BMT and UCBT are high-risk procedures with high rates of morbidity and mortality. However, they are the only treatments that have the potential to cure the disease. | [[Bone marrow transplantation]] (BMT) and [[umbilical cord blood transplantation]] (UCBT) can successfully treat the mucopolysaccharidoses. Abnormal physical characteristics, except for those affecting the skeleton and eyes, can be improved, and neurologic degeneration can often be halted. BMT and UCBT are high-risk procedures with high rates of morbidity and mortality. However, they are the only treatments that have the potential to cure the disease. | ||
==Surgery== | ==Surgery== | ||
===Bone Marrow | ===Bone Marrow Transplantation === | ||
* These procedures lead to replacement of mutated/ non-functional cells of the bone marrow with functional cells. | * These procedures lead to replacement of mutated/ non-functional cells of the bone marrow with functional cells. | ||
* Functional new cells act as a source for the deficient enzyme. | * Functional new cells act as a source for the deficient enzyme. | ||
Revision as of 03:49, 26 February 2013
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Hurler Syndrome Microchapters |
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Hurler syndrome surgery On the Web |
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Risk calculators and risk factors for Hurler syndrome surgery |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
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Overview
Bone marrow transplantation (BMT) and umbilical cord blood transplantation (UCBT) can successfully treat the mucopolysaccharidoses. Abnormal physical characteristics, except for those affecting the skeleton and eyes, can be improved, and neurologic degeneration can often be halted. BMT and UCBT are high-risk procedures with high rates of morbidity and mortality. However, they are the only treatments that have the potential to cure the disease.
Surgery
Bone Marrow Transplantation
- These procedures lead to replacement of mutated/ non-functional cells of the bone marrow with functional cells.
- Functional new cells act as a source for the deficient enzyme.
- Transplant has the best outcome when its done as soon as the diagnosis is established.
- Children who receive a transplant early enough can have normal or near-normal mental development.
- If the disease has progressed causing organ damage, the child is at high risk of developing life-threatening complications from transplant.
- Transplants cannot undo the damage done to nervous system.
- Risks of transplant