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==Overview==
==Overview==
Nocturnal [[asthma]] is defined by a drop in [[FEV1|forced expiratory volume in 1 second (FEV1)]] of at least 15% between bedtime and awakening in patients with clinical and physiologic evidence of [[asthma]].<ref name="pmid15683618">Sutherland ER (2005) [http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=15683618 Nocturnal asthma: underlying mechanisms and treatment.] ''Curr Allergy Asthma Rep'' 5 (2):161-7. PMID: [http://pubmed.gov/15683618 15683618]</ref> The pathophysiology of nocturnal asthma is closely associated with the chronobiology and the science of biologic processes that have time-related rhythms. Hence, understanding the [[circadian rhythm]] is important to interpret the changes in pulmonary function that occurs in sleeping asthmatics. A large population based study reported dyspneic episodes without therapy in asthmatics occurred between 10 P.M. and 7 A.M.<ref name="pmid8494197">Martin RJ (1993) [http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=8494197 Nocturnal asthma: circadian rhythms and therapeutic interventions.] ''Am Rev Respir Dis'' 147 (6 Pt 2):S25-8. PMID: [http://pubmed.gov/8494197 8494197]</ref> Another population based survey that assessed 7729 patients, reported approximate 74% patients woke-up at least once a week with symptoms, 64% woke-up three times per week, and 39% patients woke-up every night with symptoms.<ref name="pmid3400687">Turner-Warwick M (1988) [http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=3400687 Epidemiology of nocturnal asthma.] ''Am J Med'' 85 (1B):6-8. PMID: [http://pubmed.gov/3400687 3400687]</ref>
Nocturnal [[asthma]] is defined by a drop in [[FEV1|forced expiratory volume in 1 second (FEV1)]] of at least 15% between bedtime and awakening in patients with clinical and physiologic evidence of [[asthma]].<ref name="pmid15683618">Sutherland ER (2005) [http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=15683618 Nocturnal asthma: underlying mechanisms and treatment.] ''Curr Allergy Asthma Rep'' 5 (2):161-7. PMID: [http://pubmed.gov/15683618 15683618]</ref> The pathophysiology of nocturnal asthma is closely associated with the chronobiology and the science of biologic processes that have time-related rhythms. Hence, understanding the [[circadian rhythm]] is important to interpret the changes in pulmonary function that occurs in sleeping asthmatics. A large population based study reported dyspneic episodes without therapy in asthmatics occurred between 10 P.M. and 7 A.M.<ref name="pmid8494197">Martin RJ (1993) [http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=8494197 Nocturnal asthma: circadian rhythms and therapeutic interventions.] ''Am Rev Respir Dis'' 147 (6 Pt 2):S25-8. PMID: [http://pubmed.gov/8494197 8494197]</ref> Another population based survey that assessed 7729 patients, reported approximate 74% patients woke-up at least once a week with symptoms, 64% woke-up three times per week, and 39% patients woke-up every night with symptoms.<ref name="pmid3400687">Turner-Warwick M (1988) [http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=3400687 Epidemiology of nocturnal asthma.] ''Am J Med'' 85 (1B):6-8. PMID: [http://pubmed.gov/3400687 3400687]</ref>
==Overview==
Nocturnal worsening of asthma is very common clinical finding in asthmatics affecting approximately 75% of asthmatics who awaken at least once per week because of symptoms, and approximately 40% experience nocturnal symptoms on a nightly basis.<ref name="pmid15683618">Sutherland ER (2005) [http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=15683618 Nocturnal asthma: underlying mechanisms and treatment.] ''Curr Allergy Asthma Rep'' 5 (2):161-7. PMID: [http://pubmed.gov/15683618 15683618]</ref><ref name="pmid16337443">Sutherland ER (2005) [http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=16337443 Nocturnal asthma.] ''J Allergy Clin Immunol'' 116 (6):1179-86; quiz 1187. [http://dx.doi.org/10.1016/j.jaci.2005.09.028 DOI:10.1016/j.jaci.2005.09.028] PMID: [http://pubmed.gov/16337443 16337443]</ref>


==References==
==References==

Revision as of 14:12, 7 March 2013

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Overview

Nocturnal asthma is defined by a drop in forced expiratory volume in 1 second (FEV1) of at least 15% between bedtime and awakening in patients with clinical and physiologic evidence of asthma.[1] The pathophysiology of nocturnal asthma is closely associated with the chronobiology and the science of biologic processes that have time-related rhythms. Hence, understanding the circadian rhythm is important to interpret the changes in pulmonary function that occurs in sleeping asthmatics. A large population based study reported dyspneic episodes without therapy in asthmatics occurred between 10 P.M. and 7 A.M.[2] Another population based survey that assessed 7729 patients, reported approximate 74% patients woke-up at least once a week with symptoms, 64% woke-up three times per week, and 39% patients woke-up every night with symptoms.[3]

Overview

Nocturnal worsening of asthma is very common clinical finding in asthmatics affecting approximately 75% of asthmatics who awaken at least once per week because of symptoms, and approximately 40% experience nocturnal symptoms on a nightly basis.[1][4]

References

  1. ↑ 1.0 1.1 Sutherland ER (2005) Nocturnal asthma: underlying mechanisms and treatment. Curr Allergy Asthma Rep 5 (2):161-7. PMID: 15683618
  2. ↑ Martin RJ (1993) Nocturnal asthma: circadian rhythms and therapeutic interventions. Am Rev Respir Dis 147 (6 Pt 2):S25-8. PMID: 8494197
  3. ↑ Turner-Warwick M (1988) Epidemiology of nocturnal asthma. Am J Med 85 (1B):6-8. PMID: 3400687
  4. ↑ Sutherland ER (2005) Nocturnal asthma. J Allergy Clin Immunol 116 (6):1179-86; quiz 1187. DOI:10.1016/j.jaci.2005.09.028 PMID: 16337443

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