Dermatofibroma pathophysiology: Difference between revisions
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! Neoplasm | ! Neoplasm | ||
! [[CD34]] | ! [[CD34]] | ||
! [[Stromelysin-3]]<ref>{{cite journal | pmid = 17596171 | doi=10.1111/j.1365-2133.2007.08033.x | volume=157 | issue=2 | title=Stromelysin-3 expression in the differential diagnosis of dermatofibroma and dermatofibrosarcoma protuberans: comparison with factor XIIIa and CD34 | year=2007 | month=August | author=Kim HJ, Lee JY, Kim SH, ''et al.'' | journal=Br. J. Dermatol. | pages=319–24}}</ref> | ! [[Stromelysin-3]]<ref>{{cite journal | pmid = 17596171 | doi=10.1111/j.1365-2133.2007.08033.x | volume=157 | issue=2 | title=Stromelysin-3 expression in the differential diagnosis of dermatofibroma and dermatofibrosarcoma protuberans: comparison with factor XIIIa and CD34 | year=2007 | month=August | author=Kim HJ, Lee JY, Kim SH, ''et al.'' | journal=Br. J. Dermatol. | pages=319–24}}</ref> | ||
! [[Factor XIIIa]]<ref>http://emedicine.medscape.com/article/1056742-overview</ref> | ! [[Factor XIIIa]]<ref>http://emedicine.medscape.com/article/1056742-overview</ref> |
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Pathophysiology
- Some physicians and researchers believe dermatofibromas form as a reaction to previous injuries such as insect bites or thorn pricks.
- Dermatofibromas are composed of disordered collagen laid down by fibroblasts.
Immunohistochemical staining
Neoplasm | CD34 | Stromelysin-3[1] | Factor XIIIa[2] |
---|---|---|---|
Dermatofibroma | + | + | + |
Dermatofibrosarcoma protuberans | + | - | - |
References
- ↑ Kim HJ, Lee JY, Kim SH; et al. (2007). "Stromelysin-3 expression in the differential diagnosis of dermatofibroma and dermatofibrosarcoma protuberans: comparison with factor XIIIa and CD34". Br. J. Dermatol. 157 (2): 319–24. doi:10.1111/j.1365-2133.2007.08033.x. PMID 17596171. Unknown parameter
|month=
ignored (help) - ↑ http://emedicine.medscape.com/article/1056742-overview