Primary biliary cirrhosis (patient information): Difference between revisions
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==Treatment options== | ==Treatment options== | ||
The goal of treatment is to ease symptoms and prevent complications. | |||
[[Cholestyramine]] (or [[colestipol]]) may reduce the itching. [[Ursodeoxycholic acid]] may improve removal of bile from the bloodstream may improve survival in some patients who have taken it for 4 years. | |||
[[Vitamin]] replacement therapy restores vitamins A, K, and D, which are lost in fatty stools. A [[calcium]] supplement should be added to prevent or treat soft, weakened bones ([[osteomalacia]]). | |||
[[Liver transplant]] before liver failure occurs may be successful. | |||
==Where to find medical care for Primary biliary cirrhosis?== | ==Where to find medical care for Primary biliary cirrhosis?== | ||
Revision as of 18:37, 16 April 2013
For WikiDoc page on this topic, click here.
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Primary Biliary Cirrhosis |
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Primary biliary cirrhosis On the Web |
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Risk calculators and risk factors for Primary biliary cirrhosis |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aditya Govindavarjhulla, M.B.B.S. [2]
Overview
Primary biliary cirrhosis is irritation and swelling (inflammation) of the bile ducts of the liver, which blocks the flow of bile. This obstruction damages liver cells and leads to scarring called cirrhosis.
What are the symptoms of Primary biliary cirrhosis?
More than half of patients have no symptoms at the time of diagnosis. Symptoms usually come on gradually and may include:
- Abdominal pain
- Enlarged liver
- Fatigue
- Fatty deposits under the skin
- Fatty stools
- Itching
- Jaundice
- Soft yellow spots on the eyelid
What causes Primary biliary cirrhosis?
The cause of inflamed bile ducts in the liver is not known. However, primary biliary cirrhosis is an autoimmune disorder. That means your body's immune system mistakenly attacks healthy tissue.
The disease more commonly affects middle-aged women.
Long-term bile obstruction is believed to lead to liver cirrhosis. The disease may be associated with autoimmune disorders such as:
- Celiac disease
- Raynaud's phenomenon
- Sicca syndrome (dry eyes or mouth)
- Thyroid disease
Who is at highest risk?
Diagnosis
The doctor or nurse will perform a physical exam.
The following tests can check to see if your liver is working properly:
- Albumin blood test
- Liver function tests (serum alkaline phosphatase is most important)
- Prothrombin time (PT)
- Cholesterol and lipoprotein blood tests
Other tests that can help diagnose this disease are:
- Elevated immunoglobulin M level in the blood
- Liver biopsy
- Anti-mitochondrial antibodies (results are positive in about 95% of cases)
When to seek urgent medical care?
Treatment options
The goal of treatment is to ease symptoms and prevent complications.
Cholestyramine (or colestipol) may reduce the itching. Ursodeoxycholic acid may improve removal of bile from the bloodstream may improve survival in some patients who have taken it for 4 years.
Vitamin replacement therapy restores vitamins A, K, and D, which are lost in fatty stools. A calcium supplement should be added to prevent or treat soft, weakened bones (osteomalacia).
Liver transplant before liver failure occurs may be successful.
Where to find medical care for Primary biliary cirrhosis?
Directions to Hospitals Treating Primary biliary cirrhosis