Nephrotic syndrome physical examination

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Physical Examination

Vital Signs

• Hypertension (rarely)

Skin

• May have features of underlying cause, such as rash associated with SLE

Eyes

• Puffiness around the eyes, characteristically in the morning

Lungs

• Fluid in the pleural cavity causing pleural effusion.

Abdomen

• Fluid in the peritoneal cavity causing ascites.

Extremities

• Edema over the legs which is pitting (i.e. leaves a little pit when the fluid is pressed out, which resolves over a few seconds).

Neurologic

• May have features of underlying cause, such as neuropathy with diabetes.