Cardiac amyloidosis history and symptoms: Difference between revisions
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==Symptoms== | ==Symptoms== | ||
*Cardiac amyloid deposition can cause symptoms suggestive of:<ref name="pmid9578896">{{cite journal |author=Dubrey SW, Cha K, Anderson J, ''et al.'' |title=The clinical features of immunoglobulin light-chain (AL) amyloidosis with heart involvement |journal=[[QJM : Monthly Journal of the Association of Physicians]] |volume=91 |issue=2 |pages=141–57 |year=1998 |month=February |pmid=9578896 |doi= |url=}}</ref> | *Cardiac amyloid deposition can cause symptoms suggestive of:<ref name="pmid9578896">{{cite journal |author=Dubrey SW, Cha K, Anderson J, ''et al.'' |title=The clinical features of immunoglobulin light-chain (AL) amyloidosis with heart involvement |journal=[[QJM : Monthly Journal of the Association of Physicians]] |volume=91 |issue=2 |pages=141–57 |year=1998 |month=February |pmid=9578896 |doi= |url=}}</ref> | ||
*[[Congestive heart failure]] such as [[fatigue]], [[dyspnea]], [[orthopnea]]<ref name="pmid7878478">{{cite journal |author=Kyle RA, Gertz MA |title=Primary systemic amyloidosis: clinical and laboratory features in 474 cases |journal=[[Seminars in Hematology]] |volume=32 |issue=1 |pages=45–59 |year=1995 |month=January |pmid=7878478 |doi= |url= |accessdate=2012-02-13}}</ref>, [[peripheral edema]], [[ascites]] ''and/or'' | |||
*[[arrhythmia|Arrhythmias]] such as [[Palpitation|palpitations]] | |||
*[[Postural hypotension]] may be observed in patients with subendothelial amyloid deposition.<ref name="pmid17062380">{{cite journal |author=Rapezzi C, Perugini E, Salvi F, Grigioni F, Riva L, Cooke RM, Ferlini A, Rimessi P, Bacchi-Reggiani L, Ciliberti P, Pastorelli F, Leone O, Bartolomei I, Pinna AD, Arpesella G, Branzi A |title=Phenotypic and genotypic heterogeneity in transthyretin-related cardiac amyloidosis: towards tailoring of therapeutic strategies? |journal=[[Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis]] |volume=13 |issue=3 |pages=143–53 |year=2006 |month=September |pmid=17062380 |doi=10.1080/13506120600877136 |url=http://informahealthcare.com/doi/abs/10.1080/13506120600877136 |accessdate=2012-02-13}}</ref> | *[[Postural hypotension]] may be observed in patients with subendothelial amyloid deposition.<ref name="pmid17062380">{{cite journal |author=Rapezzi C, Perugini E, Salvi F, Grigioni F, Riva L, Cooke RM, Ferlini A, Rimessi P, Bacchi-Reggiani L, Ciliberti P, Pastorelli F, Leone O, Bartolomei I, Pinna AD, Arpesella G, Branzi A |title=Phenotypic and genotypic heterogeneity in transthyretin-related cardiac amyloidosis: towards tailoring of therapeutic strategies? |journal=[[Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis]] |volume=13 |issue=3 |pages=143–53 |year=2006 |month=September |pmid=17062380 |doi=10.1080/13506120600877136 |url=http://informahealthcare.com/doi/abs/10.1080/13506120600877136 |accessdate=2012-02-13}}</ref> | ||
Revision as of 17:47, 3 May 2013
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Cafer Zorkun, M.D., Ph.D. [2]; Lakshmi Gopalakrishnan, M.B.B.S. [3]; Raviteja Guddeti, M.B.B.S. [4]; Aarti Narayan, M.B.B.S [5]
Overview
Amyloidosis is a multi-system disease involving many organs simultaneously. Approximately more than 50% of the patients with amyloidosis present with right heart failure symptoms. The most common symptoms observed in patients with cardiac amyloidosis include fatigue, weight loss, and periorbital purpura.[1]
Symptoms
- Cardiac amyloid deposition can cause symptoms suggestive of:[2]
- Congestive heart failure such as fatigue, dyspnea, orthopnea[1], peripheral edema, ascites and/or
- Arrhythmias such as palpitations
- Postural hypotension may be observed in patients with subendothelial amyloid deposition.[3]
References
- ↑ 1.0 1.1 Kyle RA, Gertz MA (1995). "Primary systemic amyloidosis: clinical and laboratory features in 474 cases". Seminars in Hematology. 32 (1): 45–59. PMID 7878478. Unknown parameter
|month=ignored (help);|access-date=requires|url=(help) - ↑ Dubrey SW, Cha K, Anderson J; et al. (1998). "The clinical features of immunoglobulin light-chain (AL) amyloidosis with heart involvement". QJM : Monthly Journal of the Association of Physicians. 91 (2): 141–57. PMID 9578896. Unknown parameter
|month=ignored (help) - ↑ Rapezzi C, Perugini E, Salvi F, Grigioni F, Riva L, Cooke RM, Ferlini A, Rimessi P, Bacchi-Reggiani L, Ciliberti P, Pastorelli F, Leone O, Bartolomei I, Pinna AD, Arpesella G, Branzi A (2006). "Phenotypic and genotypic heterogeneity in transthyretin-related cardiac amyloidosis: towards tailoring of therapeutic strategies?". Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 13 (3): 143–53. doi:10.1080/13506120600877136. PMID 17062380. Retrieved 2012-02-13. Unknown parameter
|month=ignored (help)