Cardiac amyloidosis natural history, complications and prognosis: Difference between revisions
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==Complications== | ==Complications== | ||
* | * [[Congestive heart failure]] | ||
* [[Sudden cardiac death]] | * [[Sudden cardiac death]] | ||
* [[Atrial fibrillation]] | * [[Myocardial infarction]] | ||
* [[Atrial fibrillation]] | |||
* [[Tachyarrhythmia]]s | |||
* [[Ventricular arrhythmia]]s | |||
* [[Sick sinus syndrome]] (occasionally) and [[heart block]]s | * [[Sick sinus syndrome]] (occasionally) and [[heart block]]s | ||
* Symptomatic cardiac conduction system disease (arrhythmias related to abnormal conduction of impulses through the heart muscle) | * Symptomatic cardiac conduction system disease (arrhythmias related to abnormal conduction of impulses through the heart muscle) | ||
| Line 18: | Line 21: | ||
* [[Ascites]] (fluid accumulation in the abdomen) | * [[Ascites]] (fluid accumulation in the abdomen) | ||
* [[Cardiac tamponade]]<ref name="pmid1428240">{{cite journal |author=Navarro JF, Rivera M, Ortuño J |title=Cardiac tamponade as presentation of systemic amyloidosis |journal=[[International Journal of Cardiology]] |volume=36 |issue=1 |pages=107–8 |year=1992 |month=July |pmid=1428240 |doi= |url=}}</ref> | * [[Cardiac tamponade]]<ref name="pmid1428240">{{cite journal |author=Navarro JF, Rivera M, Ortuño J |title=Cardiac tamponade as presentation of systemic amyloidosis |journal=[[International Journal of Cardiology]] |volume=36 |issue=1 |pages=107–8 |year=1992 |month=July |pmid=1428240 |doi= |url=}}</ref> | ||
* [[Stroke]] due to | * [[Stroke]] and [[claudication]] due to [[intracardiac thrombus]] causing [[thromboembolism]] | ||
==References== | ==References== | ||
Revision as of 00:10, 5 May 2013
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor: Cafer Zorkun, M.D., Ph.D. [2]; Lakshmi Gopalakrishnan, M.B.B.S. [3]
Overview
The presence or absence of cardiac involvement with amyloid is the most important prognostic factor.[1]
Prognosis
Cardiac amyloidosis is a chronic and progressive condition. A cardiologist may estimate the prognosis according to the thickness of the left ventricle and to the degree of restriction in the heart (diastolic dysfunction). For primary amyloidosis, the median survival after diagnosis is about 2.1 years.
Complications
- Congestive heart failure
- Sudden cardiac death
- Myocardial infarction
- Atrial fibrillation
- Tachyarrhythmias
- Ventricular arrhythmias
- Sick sinus syndrome (occasionally) and heart blocks
- Symptomatic cardiac conduction system disease (arrhythmias related to abnormal conduction of impulses through the heart muscle)
- Low blood pressure and dizziness from excessive urination (from medication)
- Increased sensitivity to digoxin with the potential for digoxin toxicity and related arrhythmias. The amyloid protein tends to bind the digoxin and increase its local concentration in the conduction system for instance.
- Ascites (fluid accumulation in the abdomen)
- Cardiac tamponade[2]
- Stroke and claudication due to intracardiac thrombus causing thromboembolism
References
- ↑ Gertz MA, Lacy MQ, Dispenzieri A (1999). "Amyloidosis: recognition, confirmation, prognosis, and therapy". Mayo Clinic Proceedings. Mayo Clinic. 74 (5): 490–4. doi:10.4065/74.5.490. PMID 10319082. Retrieved 2012-02-13. Unknown parameter
|month=ignored (help) - ↑ Navarro JF, Rivera M, Ortuño J (1992). "Cardiac tamponade as presentation of systemic amyloidosis". International Journal of Cardiology. 36 (1): 107–8. PMID 1428240. Unknown parameter
|month=ignored (help)