Cardiac amyloidosis laboratory findings: Difference between revisions
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* Serum [[troponin]]s: Cardiac troponins are elevated due to myonecrosis and small-vessel disease due to deposition of amyloid in the heart. Troponins are of both diagnostic and prognostic importance. Studies have shown worse survival rates in patients with systemic amyloidosis and cardiac involvement compared to those without cardiac involvement. | * Serum [[troponin]]s: Cardiac troponins are elevated due to myonecrosis and small-vessel disease due to deposition of amyloid in the heart. Troponins are of both diagnostic and prognostic importance. Studies have shown worse survival rates in patients with systemic amyloidosis and cardiac involvement compared to those without cardiac involvement. | ||
* [[Atrial natriuretic peptide]]: Elevated in heart failure | * [[Atrial natriuretic peptide]]: Elevated in heart failure | ||
* [[Brain natriuretic peptide]]: Elevated in heart failure | * [[Brain natriuretic peptide]]: Elevated in heart failure. N-terminal proBNP is the most sensitive marker of heart dysfunction in amyloid patients. | ||
* Serum [[transthyretin]] | * Serum [[transthyretin]] | ||
* Urinalysis for [[proteinuria]] | * Urinalysis for [[proteinuria]] | ||
Revision as of 21:18, 4 May 2013
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Cardiac amyloidosis Microchapters |
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Diagnosis |
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Treatment |
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Cardiac amyloidosis laboratory findings On the Web |
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Risk calculators and risk factors for Cardiac amyloidosis laboratory findings |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Raviteja Guddeti, M.B.B.S. [2]; Aarti Narayan, M.B.B.S [3]; Lakshmi Gopalakrishnan, M.B.B.S. [4]
Overview
There is no specific diagnostic blood test, radiograph, or scan that can be used to diagnose amyloidosis; hence, awareness of the disease is necessary to identify patients with amyloidosis.[1]
Laboratory Findings
The following are the laboratory tests included in the management of cardiac amyloidosis:
- Complete blood count: Normocytic normochromic anemia may be present
- Serum troponins: Cardiac troponins are elevated due to myonecrosis and small-vessel disease due to deposition of amyloid in the heart. Troponins are of both diagnostic and prognostic importance. Studies have shown worse survival rates in patients with systemic amyloidosis and cardiac involvement compared to those without cardiac involvement.
- Atrial natriuretic peptide: Elevated in heart failure
- Brain natriuretic peptide: Elevated in heart failure. N-terminal proBNP is the most sensitive marker of heart dysfunction in amyloid patients.
- Serum transthyretin
- Urinalysis for proteinuria
- Serum and urine electrophoresis
- Serum and urine immunofixation
- Serum electrolytes
References
- ↑ Hawkins PN (1997). "The diagnosis, natural history and treatment of amyloidosis. The Goulstonian Lecture 1995". Journal of the Royal College of Physicians of London. 31 (5): 552–60. PMID 9429195.
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