Porokeratosis: Difference between revisions
Rim Halaby (talk | contribs) No edit summary |
Rim Halaby (talk | contribs) |
||
| Line 12: | Line 12: | ||
==Classification== | ==Classification== | ||
Porokeratosis may be divided into the following clinical types: | Porokeratosis may be divided into the following clinical types: | ||
:* | :* Classic porokeratosis Mibelli | ||
:* | :* Disseminated superficial actinic porokeratosis | ||
:* | :* Disseminated superficial porokeratosis | ||
:* | :* Porokeratosis palmaris et plantaris disseminata | ||
:* | :* Linear porokeratosis | ||
:* | :* Punctate porokeratosis | ||
:* | :* Porokeratosis plantaris discreta<ref name="Andrews">James, William; Berger, Timothy; Elston, Dirk (2005). ''Andrews' Diseases of the Skin: Clinical Dermatology''. (10th ed.). Saunders. ISBN 0-7216-2921-0.</ref> | ||
==Causes== | ==Causes== | ||
Revision as of 21:46, 30 July 2013
|
WikiDoc Resources for Porokeratosis |
|
Articles |
|---|
|
Most recent articles on Porokeratosis Most cited articles on Porokeratosis |
|
Media |
|
Powerpoint slides on Porokeratosis |
|
Evidence Based Medicine |
|
Clinical Trials |
|
Ongoing Trials on Porokeratosis at Clinical Trials.gov Trial results on Porokeratosis Clinical Trials on Porokeratosis at Google
|
|
Guidelines / Policies / Govt |
|
US National Guidelines Clearinghouse on Porokeratosis NICE Guidance on Porokeratosis
|
|
Books |
|
News |
|
Commentary |
|
Definitions |
|
Patient Resources / Community |
|
Patient resources on Porokeratosis Discussion groups on Porokeratosis Patient Handouts on Porokeratosis Directions to Hospitals Treating Porokeratosis Risk calculators and risk factors for Porokeratosis
|
|
Healthcare Provider Resources |
|
Causes & Risk Factors for Porokeratosis |
|
Continuing Medical Education (CME) |
|
International |
|
|
|
Business |
|
Experimental / Informatics |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Mugilan Poongkunran M.B.B.S [2]
Overview
Porokeratosis is a specific disorder of epidermal keratinization that is characterized histologically by the presence of a cornoid lamella, a thin column of closely stacked parakeratotic cells extending through the stratum corneum with a thin or absent granular layer.[1]
Historical Perspective
Porokeratosis was first described by Mibelli in 1893.
Classification
Porokeratosis may be divided into the following clinical types:
- Classic porokeratosis Mibelli
- Disseminated superficial actinic porokeratosis
- Disseminated superficial porokeratosis
- Porokeratosis palmaris et plantaris disseminata
- Linear porokeratosis
- Punctate porokeratosis
- Porokeratosis plantaris discreta[2]
Causes
The etiology of porokeratosis is still unclear. An autosomal dominant inheritance has been established for classic porokeratosis Mibelli, disseminated superficial actinic porokeratosis, disseminated superficial porokeratosis, porokeratosis palmaris et plantaris disseminata.
Risk Factors
- Sun exposure
- Virus infection
- Immunosuppression
- Radioactivity
Epidemiology and Demographics
It frequently appears in childhood but may appear at any age, especially in nonhereditary cases, with a higher incidence in males.
Diagnosis
Physical Findings
- Classic porokeratosis Mibelli consists of a single plaque or a small number of plaques of variable size, usually located unilaterally on limbs.
- Disseminated superficial porokeratosis is a variant of classic porokeratosis Mibelli characterized by small erythematous or pigmented keratotic papules with central atrophy, located on the trunk, genitals, palms, and soles.
- Linear porokeratosis usually arises as plaques that follows Blaschko's lines.
Laboratory Findings
Histopathological examination reveals typical cornoid lamella confirming the diagnosis of porokeratosis.
Treatment
Skin care with topical isotretinoin 0.1% cream once daily and 5% urea.