Contrast induced nephropathy epidemiology and demographics: Difference between revisions
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==Overview== | ==Overview== | ||
An overall incidence of CIN in the general population is reported to be 0.6–2.3%.<ref name="pmid9169676">{{cite journal| author=Lasser EC, Lyon SG, Berry CC| title=Reports on contrast media reactions: analysis of data from reports to the U.S. Food and Drug Administration. | journal=Radiology | year= 1997 | volume= 203 | issue= 3 | pages= 605-10 | pmid=9169676 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9169676 }} </ref> CIN is third most common cause of renal failure, the overall mortality rate was 19.4% and was similar among patients for all causes of renal insufficiency.<ref name="pmid11979336">{{cite journal| author=Nash K, Hafeez A, Hou S| title=Hospital-acquired renal insufficiency. | journal=Am J Kidney Dis | year= 2002 | volume= 39 | issue= 5 | pages= 930-6 | pmid=11979336 | doi=10.1053/ajkd.2002.32766 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11979336 }} </ref> | |||
==Epidemiology and Demographics== | ==Epidemiology and Demographics== | ||
Decline in renal function remains a common event despite the improvement in the care of hospitalized patients. An overall incidence of CIN in the general population is reported to be 0.6–2.3%.<ref name="pmid9169676">{{cite journal| author=Lasser EC, Lyon SG, Berry CC| title=Reports on contrast media reactions: analysis of data from reports to the U.S. Food and Drug Administration. | journal=Radiology | year= 1997 | volume= 203 | issue= 3 | pages= 605-10 | pmid=9169676 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9169676 }} </ref> | Decline in renal function remains a common event despite the improvement in the care of hospitalized patients, the incidence rate of contrast-induced nephropathy as a complication of radiographic diagnostic and interventional studies varies markedly depending on the definition used, and on other variables such as the type of radiology procedure performed, the dose and type of contrast agent administered, the different patient populations in regard to number and type of risk factors, and the length of patient follow-up. | ||
Incidence varies in many studies according to the definition used, it is found to be 14.5% in a large epidemiological study<ref name="pmid9375704">{{cite journal| author=McCullough PA, Wolyn R, Rocher LL, Levin RN, O'Neill WW| title=Acute renal failure after coronary intervention: incidence, risk factors, and relationship to mortality. | journal=Am J Med | year= 1997 | volume= 103 | issue= 5 | pages= 368-75 | pmid=9375704 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9375704 }} </ref>, in which CIN defined as > 25% increase in serum creatinine levels over baseline in the first 5 days, Rates may vary depending on the presence of risk factors, patients with diabetes has been reported to be 9–40% in patients with mild-to-moderate chronic renal insufficiency, and 50–90% in those with severe chronic renal insufficiency.<ref name="pmid605916">{{cite journal| author=Harkonen S, Kjellstrand CM| title=Exacerbation of diabetic renal failure following intravenous pyelography. | journal=Am J Med | year= 1977 | volume= 63 | issue= 6 | pages= 939-46 | pmid=605916 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=605916 }} </ref> <ref name="pmid2239981">{{cite journal| author=Manske CL, Sprafka JM, Strony JT, Wang Y| title=Contrast nephropathy in azotemic diabetic patients undergoing coronary angiography. | journal=Am J Med | year= 1990 | volume= 89 | issue= 5 | pages= 615-20 | pmid=2239981 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2239981 }} </ref> An overall incidence of CIN in the general population is reported to be 0.6–2.3%.<ref name="pmid9169676">{{cite journal| author=Lasser EC, Lyon SG, Berry CC| title=Reports on contrast media reactions: analysis of data from reports to the U.S. Food and Drug Administration. | journal=Radiology | year= 1997 | volume= 203 | issue= 3 | pages= 605-10 | pmid=9169676 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9169676 }} </ref> The overall mortality rate was 19.4% and was similar among patients for all causes of renal insufficiency, except sepsis. <ref name="pmid11979336">{{cite journal| author=Nash K, Hafeez A, Hou S| title=Hospital-acquired renal insufficiency. | journal=Am J Kidney Dis | year= 2002 | volume= 39 | issue= 5 | pages= 930-6 | pmid=11979336 | doi=10.1053/ajkd.2002.32766 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11979336 }} </ref> | |||
==References== | ==References== | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohamed Moubarak, M.D. [2]
Overview
An overall incidence of CIN in the general population is reported to be 0.6–2.3%.[1] CIN is third most common cause of renal failure, the overall mortality rate was 19.4% and was similar among patients for all causes of renal insufficiency.[2]
Epidemiology and Demographics
Decline in renal function remains a common event despite the improvement in the care of hospitalized patients, the incidence rate of contrast-induced nephropathy as a complication of radiographic diagnostic and interventional studies varies markedly depending on the definition used, and on other variables such as the type of radiology procedure performed, the dose and type of contrast agent administered, the different patient populations in regard to number and type of risk factors, and the length of patient follow-up.
Incidence varies in many studies according to the definition used, it is found to be 14.5% in a large epidemiological study[3], in which CIN defined as > 25% increase in serum creatinine levels over baseline in the first 5 days, Rates may vary depending on the presence of risk factors, patients with diabetes has been reported to be 9–40% in patients with mild-to-moderate chronic renal insufficiency, and 50–90% in those with severe chronic renal insufficiency.[4] [5] An overall incidence of CIN in the general population is reported to be 0.6–2.3%.[1] The overall mortality rate was 19.4% and was similar among patients for all causes of renal insufficiency, except sepsis. [2]
References
- ↑ 1.0 1.1 Lasser EC, Lyon SG, Berry CC (1997). "Reports on contrast media reactions: analysis of data from reports to the U.S. Food and Drug Administration". Radiology. 203 (3): 605–10. PMID 9169676.
- ↑ 2.0 2.1 Nash K, Hafeez A, Hou S (2002). "Hospital-acquired renal insufficiency". Am J Kidney Dis. 39 (5): 930–6. doi:10.1053/ajkd.2002.32766. PMID 11979336.
- ↑ McCullough PA, Wolyn R, Rocher LL, Levin RN, O'Neill WW (1997). "Acute renal failure after coronary intervention: incidence, risk factors, and relationship to mortality". Am J Med. 103 (5): 368–75. PMID 9375704.
- ↑ Harkonen S, Kjellstrand CM (1977). "Exacerbation of diabetic renal failure following intravenous pyelography". Am J Med. 63 (6): 939–46. PMID 605916.
- ↑ Manske CL, Sprafka JM, Strony JT, Wang Y (1990). "Contrast nephropathy in azotemic diabetic patients undergoing coronary angiography". Am J Med. 89 (5): 615–20. PMID 2239981.