WBR0387

Author	[[PageAuthor::Rim Halaby, M.D. [1]]]
Exam Type	ExamType::USMLE Step 1
Main Category	MainCategory::Physiology
Sub Category	SubCategory::Renal
Prompt	[[Prompt::A researcher is studying the role of aldosterone at the level of renal tubules. He conducts an experiment whereby he measures urinary concentration of sodium, potassium, and hydrogen before and after aldosterone administration. With respect to urinary concentrations before the administration of aldosterone, which of the following parameters is true for concentrations of urinary sodium, potassium, and hydrogen (in order) after aldosterone administration? ]]
Answer A	[[AnswerA::Increased - Decreased - Decreased]]
Answer A Explanation	AnswerAExp::An increase in sodium, accompanied by a decrease in potassium and hydrogen, is seen in the serum, not in urine.
Answer B	[[AnswerB::Increased - Increased - Decreased]]
Answer B Explanation	AnswerBExp::Following aldosterone administration, urinary sodium is decreased due to aldsoterone’s activity in reabsorbing sodium, and urinary hydrogen is increased due to aldosterone’s activity in excreting hydrogen.
Answer C	AnswerC::Decreased - Increased - Increased
Answer C Explanation	AnswerCExp::Aldosterone accelerates the ion exchange of sodium for potassium or hydrogen; allowing increased reabsorption of sodium and excretion of both potassium and hydrogen.
Answer D	AnswerD::Decreased - Increased - Unchanged
Answer D Explanation	AnswerDExp::Following aldosterone administration, hydrogen is excreted. Its urinary concentration will be increased. It will not remain unchanged.
Answer E	AnswerE::Decreased - Decreased - Increased
Answer E Explanation	AnswerEExp::Following aldosterone administration, urinary potassium increases, while serum potassium is decreased due to aldosterone’s activity in excreting potassium.
Right Answer	RightAnswer::C
Explanation	[[Explanation::Aldosterone accelerates the ion exchange of sodium for potassium or hydrogen. Aldosterone acts at the level of collecting ducts to reabsorb sodium, and excrete potassium and hydrogen. Thus, urinary concentrations of sodium will be decreased, while urinary concentrations of potassium and hydrogen will be increased. Educational Objective: Aldosterone acts on the renal collecting tubule. It accelerates the ion exchange of sodium for potassium or hydrogen; allowing increased reabsorption of sodium and excretion of both potassium and hydrogen. Educational Objective: References: ]]
Approved	Approved::No
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Order in Linked Questions	LinkedOrder::