High chylomicron remnant causes: Difference between revisions

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Revision as of 21:24, 8 November 2013

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mugilan Poongkunran M.B.B.S [2]

Overview

The high chylomicron remnants could either be due to genetic conditions as in type I and type V hyperlipoproteinemia or secondary to conditions such as chronic renal failure, hypothyroidism, and diabetes mellitus. Secondary causes are more frequent than primary genetic etiologies.

Causes

Life Threatening Causes

Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated.

Hyperchylomicronemia does not have life-threatening causes.

Common Causes

Causes by Organ System

Cardiovascular	No underlying causes
Chemical/Poisoning	No underlying causes
Dental	No underlying causes
Dermatologic	No underlying causes
Drug Side Effect	Heparin, oral contraceptives, thiazide diuretics
Ear Nose Throat	No underlying causes
Endocrine	Diabetes mellitus, hypothyroidism
Environmental	No underlying causes
Gastroenterologic	No underlying causes
Genetic	Glycogen storage disease type I, lipoprotein lipase deficiency, type 1C hyperlipoproteinemia, mixed hyperlipoproteinemia
Hematologic	No underlying causes
Iatrogenic	No underlying causes
Infectious Disease	No underlying causes
Musculoskeletal/Orthopedic	No underlying causes
Neurologic	No underlying causes
Nutritional/Metabolic	Familial hypertriglyceridemia, glycogen storage disease type I, lipoprotein lipase deficiency
Obstetric/Gynecologic	Pregnancy
Oncologic	No underlying causes
Ophthalmologic	No underlying causes
Overdose/Toxicity	Alcohol
Psychiatric	No underlying causes
Pulmonary	No underlying causes
Renal/Electrolyte	Chronic renal failure
Rheumatology/Immunology/Allergy	Autoimmune hyperchylomicronemia ^[1]
Sexual	No underlying causes
Trauma	No underlying causes
Urologic	No underlying causes
Miscellaneous	No underlying causes

Causes by Alphabetical Order

References

↑ ^1.0 ^1.1 Yoshimura, T.; Ito, M.; Sakoda, Y.; Kobori, S.; Okamura, H. (1998). "Rare case of autoimmune hyperchylomicronemia during pregnancy". Eur J Obstet Gynecol Reprod Biol. 76 (1): 49–51. PMID 9481547. Unknown parameter |month= ignored (help)

[Yoshimura-1998-1] 1.0 ^1.1 Yoshimura, T.; Ito, M.; Sakoda, Y.; Kobori, S.; Okamura, H. (1998). "Rare case of autoimmune hyperchylomicronemia during pregnancy". Eur J Obstet Gynecol Reprod Biol. 76 (1): 49–51. PMID 9481547. Unknown parameter |month= ignored (help)

[1]

@@ Line 1: / Line 1: @@
 __NOTOC__
 {{Chylomicron remnant}}
-{{CMG}}
+{{CMG}}; {{AE}} {{M.P}}
 ==Overview==
+The high chylomicron remnants could either be due to [[genetic]] conditions as in [[Hyperlipoproteinemia|type I and type V hyperlipoproteinemia]] or secondary to conditions such as [[chronic renal failure]], [[hypothyroidism]], and [[diabetes mellitus]].  Secondary causes are more frequent than primary genetic etiologies.
-==High Chylomicron Remnant Causes==
+==Causes==
 ===Life Threatening Causes===
+Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated.
+Hyperchylomicronemia does not have life-threatening causes.
 ===Common Causes===
+*[[Alcoholism]]
+*[[Chronic renal failure]]
+*[[Diabetes mellitus]]
+*[[Hypothyroidism]]
+*[[Combined oral contraceptive pill|Oral contraceptives]]
+*[[Pregnancy]]
+*[[Thiazide|Thiazide diuretics]]
 ===Causes by Organ System===
+{|style="width:80%; height:100px" border="1"
+|style="height:100px"; style="width:25%" border="1" bgcolor="LightSteelBlue" |'''Cardiovascular'''
+|style="height:100px"; style="width:75%" border="1" bgcolor="Beige" | No underlying causes
+|-
+|bgcolor="LightSteelBlue"| '''Chemical/Poisoning'''
+|bgcolor="Beige"| No underlying causes
+|-
+|-bgcolor="LightSteelBlue"
+| '''Dental'''
+|bgcolor="Beige"| No underlying causes
+|-
+|-bgcolor="LightSteelBlue"
+| '''Dermatologic'''
+|bgcolor="Beige"| No underlying causes
+|-
+|-bgcolor="LightSteelBlue"
+| '''Drug Side Effect'''
+|bgcolor="Beige"| [[Heparin]], [[Combined oral contraceptive pill|oral contraceptives]], [[Thiazide|thiazide diuretics]]
+|-
+|-bgcolor="LightSteelBlue"
+| '''Ear Nose Throat'''
+|bgcolor="Beige"| No underlying causes
+|-
+|-bgcolor="LightSteelBlue"
+| '''Endocrine'''
+|bgcolor="Beige"| [[Diabetes mellitus]], [[hypothyroidism]]
+|-
+|-bgcolor="LightSteelBlue"
+| '''Environmental'''
+|bgcolor="Beige"| No underlying causes
+|-
+|-bgcolor="LightSteelBlue"
+| '''Gastroenterologic'''
+|bgcolor="Beige"| No underlying causes
+|-
+|-bgcolor="LightSteelBlue"
+| '''Genetic'''
+|bgcolor="Beige"| [[Glycogen storage disease type I]], [[lipoprotein lipase deficiency]], [[familial hyperchylomicronemia|type 1C hyperlipoproteinemia]], [[mixed hyperlipoproteinemia ]]
+|-
+|-bgcolor="LightSteelBlue"
+| '''Hematologic'''
+|bgcolor="Beige"| No underlying causes
+|-
+|-bgcolor="LightSteelBlue"
+| '''Iatrogenic'''
+|bgcolor="Beige"| No underlying causes
+|-
+|-bgcolor="LightSteelBlue"
+| '''Infectious Disease'''
+|bgcolor="Beige"| No underlying causes
+|-
+|-bgcolor="LightSteelBlue"
+| '''Musculoskeletal/Orthopedic'''
+|bgcolor="Beige"| No underlying causes
+|-
+|-bgcolor="LightSteelBlue"
+| '''Neurologic'''
+|bgcolor="Beige"| No underlying causes
+|-
+|-bgcolor="LightSteelBlue"
+| '''Nutritional/Metabolic'''
+|bgcolor="Beige"| [[Familial hypertriglyceridemia]], [[glycogen storage disease type I]], [[lipoprotein lipase deficiency]]
+|-
+|-bgcolor="LightSteelBlue"
+| '''Obstetric/Gynecologic'''
+|bgcolor="Beige"| [[Pregnancy]]
+|-
+|-bgcolor="LightSteelBlue"
+| '''Oncologic'''
+|bgcolor="Beige"| No underlying causes
+|-
+|-bgcolor="LightSteelBlue"
+| '''Ophthalmologic'''
+|bgcolor="Beige"| No underlying causes
+|-
+|-bgcolor="LightSteelBlue"
+| '''Overdose/Toxicity'''
+|bgcolor="Beige"| [[Alcoholism|Alcohol]]
+|-
+|-bgcolor="LightSteelBlue"
+| '''Psychiatric'''
+|bgcolor="Beige"| No underlying causes
+|-
+|-bgcolor="LightSteelBlue"
+| '''Pulmonary'''
+|bgcolor="Beige"| No underlying causes
+|-
+|-bgcolor="LightSteelBlue"
+| '''Renal/Electrolyte'''
+|bgcolor="Beige"| [[Chronic renal failure]]
+|-
+|-bgcolor="LightSteelBlue"
+| '''Rheumatology/Immunology/Allergy'''
+|bgcolor="Beige"| [[Autoimmune hyperchylomicronemia ]]<ref name="Yoshimura-1998">{{Cite journal | last1 = Yoshimura | first1 = T. | last2 = Ito | first2 = M. | last3 = Sakoda | first3 = Y. | last4 = Kobori | first4 = S. | last5 = Okamura | first5 = H. | title = Rare case of autoimmune hyperchylomicronemia during pregnancy. | journal = Eur J Obstet Gynecol Reprod Biol | volume = 76 | issue = 1 | pages = 49-51 | month = Jan | year = 1998 | doi = | PMID = 9481547 }}</ref>
+|-
+|-bgcolor="LightSteelBlue"
+| '''Sexual'''
+|bgcolor="Beige"| No underlying causes
+|-
+|-bgcolor="LightSteelBlue"
+| '''Trauma'''
+|bgcolor="Beige"| No underlying causes
+|-
+|-bgcolor="LightSteelBlue"
+| '''Urologic'''
+|bgcolor="Beige"| No underlying causes
+|-
+|-bgcolor="LightSteelBlue"
+| '''Miscellaneous'''
+|bgcolor="Beige"| No underlying causes
+|-
+|}
 ===Causes by Alphabetical Order===
+{{col-begin|width=80%}}
+{{col-break|width=33%}}
+*[[Alcoholism]]
+*[[Autoimmune hyperchylomicronemia]]<ref name="Yoshimura-1998">{{Cite journal | last1 = Yoshimura | first1 = T. | last2 = Ito | first2 = M. | last3 = Sakoda | first3 = Y. | last4 = Kobori | first4 = S. | last5 = Okamura | first5 = H. | title = Rare case of autoimmune hyperchylomicronemia during pregnancy. | journal = Eur J Obstet Gynecol Reprod Biol | volume = 76 | issue = 1 | pages = 49-51 | month = Jan | year = 1998 | doi = | PMID = 9481547 }}</ref>
+*[[Chronic renal failure]]
+*[[Diabetes mellitus]]
+*[[Familial hyperchylomicronemia|Type 1B hyperlipoproteinemia]]
+*[[Familial hypertriglyceridemia]]
+*[[Glycogen storage disease type I]]
+*[[Heparin]]
+*[[Hypothyroidism]]
+*[[Familial hyperchylomicronemia|Lipoprotein lipase deficiency]]
+*[[Combined oral contraceptive pill|Oral contraceptives]]
+*[[Pregnancy]]
+*[[Thiazide|Thiazide diuretics]]
+*[[Familial hyperchylomicronemia|Type 1C hyperlipoproteinemia]]
+*[[Mixed hyperlipoproteinemia ]]
+{{col-end}}
 ==References==
@@ Line 25: / Line 166: @@
 [[Category:Lipoproteins]]
 {{WikiDoc Help Menu}}
-{{WikiDoc Sources}}

v t e Lipopedia
Basic Science	Cholesterol • Triglyceride Lipoprotein metabolism and transport Lipoprotein: Chylomicron • Chylomicron remnant • HDL • IDL • LDL • Lipoprotein(a) • VLDL • Lipoprotein-X Apolipoprotein: APOA (1, 2, 4, 5) • APOB ( Apolipoprotein B-48, Apolipoprotein B-100) • APOC (1, 2, 3, 4) • APOD • APOE • APOH • APOJ • APOL • APOM • Apo(a) Lipoprotein receptor: LDL receptor • Soluble low density lipoprotein receptor-related protein (sLRP) • Apolipoprotein E Receptor 2 • Scavenger receptor • Scavenger receptor A • Scavenger receptor B • VLDL receptor Lipoprotein enzymes: Lipoprotein lipase • Lipoprotein-associated phospholipase A2 (Lp-PLA2) • Cholesterylester transfer protein ( Acetyl-CoA C-acyltransferase, Lecithin-cholesterol acyltransferase) • Microsomal triglyceride transfer protein • ABCA1 Genes: Low density lipoprotein receptor gene family • Microsomal triglyceride transfer protein • ABCA1
Lipoprotein Disorders	Lipoprotein disorders Primary lipoprotein disorders: Familial hyperchylomicronemia (Type I) • Familial hypercholesterolemia (Type IIA) • Familial combined hyperlipidemia (Type IIB) • Dysbetalipoproteinemia (Type III) • Primary hypertriglyceridemia (Type IV) • Mixed hyperlipoproteinemia (Type V) Secondary lipoprotein disorders
Abnormal Laboratory Lipid Profile	Low chylomicron • Low chylomicron remnant • Low HDL • Low IDL • Low LDL • Low lipoprotein(a) • Low VLDL High chylomicron • High chylomicron remnant • High HDL • High IDL • High LDL • High Lipoprotein(a) • High VLDL