High LDL causes: Difference between revisions

	Low Density Lipoprotein Microchapters
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Revision as of 16:31, 17 September 2013

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Cafer Zorkun, M.D., Ph.D. [2]; Rim Halaby, M.D. [3]; Vendhan Ramanujam M.B.B.S [4]

Overview

Causes

Life Threatening Causes

Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated.

Common Causes

Causes by Organ System

Cardiovascular	No underlying causes
Chemical/Poisoning	Diterpenoids
Dental	No underlying causes
Dermatologic	No underlying causes
Drug Side Effect	Atazanavir sulfate, azathioprine, bexarotene, calcineurin inhibitors, chlortalidone, corticosteroids, cyclosporine, desvenlafaxine, fish oil supplementation, immunosuppressive agents, levonorgestrel, lopinavir, mycophenolate, nicotine, norgestrel, prednisone, progestin, rapamycin, rosiglitazone, sirolimus, thiazide, tocilizumab
Ear Nose Throat	No underlying causes
Endocrine	17 alpha alkylated androgens, dehydroepiandrosterone, growth hormone deficiency, hypercortisolism, hypothyroidism, poly cystic ovarian syndrome, progestagens, subclinical hypothyroidism, testosterone
Environmental	No underlying causes
Gastroenterologic	No underlying causes
Genetic	Acid sphingomyelinase deficiency, autosomal recessive hypercholesterolemia, familial combined hyperlipidemia, familial defective apolipoprotein B-100, familial hypercholesterolemia, hyperapobetalipoproteinemia, IL 28B polymorphisms, Niemann-pick disease, polygenic hypercholesterolemia
Hematologic	No underlying causes
Iatrogenic	No underlying causes
Infectious Disease	Gram negative bacillary bacteremia, H. pylori, small bowel bacterial overgrowth syndrome,
Musculoskeletal/Orthopedic	No underlying causes
Neurologic	No underlying causes
Nutritional/Metabolic	Chenodeoxycholic acid, high carbohydrate diet, high saturated fat diet, omega-3 polyunsaturated fatty acids, polygenic hypercholesterolemia, primary hyperlipoproteinemia, primary hypolipoproteinemia type 1, selenium deficiency
Obstetric/Gynecologic	Polycystic ovarian syndrome
Oncologic	No underlying causes
Ophthalmologic	No underlying causes
Overdose/Toxicity	No underlying causes
Psychiatric	No underlying causes
Pulmonary	No underlying causes
Renal/Electrolyte	Chronic kidney disease, nephrotic syndrome
Rheumatology/Immunology/Allergy	Dysproteinemia, lipopolysaccharides, monoclonal gammopathies, paraproteinemia
Sexual	No underlying causes
Trauma	No underlying causes
Urologic	No underlying causes
Miscellaneous	No underlying causes

Causes in Alphabetical Order

References

Template:WikiDoc Sources

v t e Lipopedia
Basic Science	Cholesterol • Triglyceride Lipoprotein metabolism and transport Lipoprotein: Chylomicron • Chylomicron remnant • HDL • IDL • LDL • Lipoprotein(a) • VLDL • Lipoprotein-X Apolipoprotein: APOA (1, 2, 4, 5) • APOB ( Apolipoprotein B-48, Apolipoprotein B-100) • APOC (1, 2, 3, 4) • APOD • APOE • APOH • APOJ • APOL • APOM • Apo(a) Lipoprotein receptor: LDL receptor • Soluble low density lipoprotein receptor-related protein (sLRP) • Apolipoprotein E Receptor 2 • Scavenger receptor • Scavenger receptor A • Scavenger receptor B • VLDL receptor Lipoprotein enzymes: Lipoprotein lipase • Lipoprotein-associated phospholipase A2 (Lp-PLA2) • Cholesterylester transfer protein ( Acetyl-CoA C-acyltransferase, Lecithin-cholesterol acyltransferase) • Microsomal triglyceride transfer protein • ABCA1 Genes: Low density lipoprotein receptor gene family • Microsomal triglyceride transfer protein • ABCA1
Lipoprotein Disorders	Lipoprotein disorders Primary lipoprotein disorders: Familial hyperchylomicronemia (Type I) • Familial hypercholesterolemia (Type IIA) • Familial combined hyperlipidemia (Type IIB) • Dysbetalipoproteinemia (Type III) • Primary hypertriglyceridemia (Type IV) • Mixed hyperlipoproteinemia (Type V) Secondary lipoprotein disorders
Abnormal Laboratory Lipid Profile	Low chylomicron • Low chylomicron remnant • Low HDL • Low IDL • Low LDL • Low lipoprotein(a) • Low VLDL High chylomicron • High chylomicron remnant • High HDL • High IDL • High LDL • High Lipoprotein(a) • High VLDL

@@ Line 1: / Line 1: @@
 __NOTOC__
 {{LDL}}
-{{CMG}}; {{AE}} {{CZ}}; {{Rim}}
+{{CMG}}; {{AE}} {{CZ}}; {{Rim}}; {{VR}}
 ==Overview==
-==Causes of High LDL==
+==Causes==
-* Acute myocardial infarction
+===Life Threatening Causes===
-* [[Diabetes Mellitus]]
+Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated.
-* Drugs
-* High fat diet
-* [[Ddx:Hypothyroidism|Hypothyroidism]]
+===Common Causes===
-* [[Nephrotic Syndrome]]
-* Obstructive liver disease
-* Primary hyperlipoproteinemia
+===Causes by Organ System===
+{|style="width:80%; height:100px" border="1"
+|style="height:100px"; style="width:25%" border="1" bgcolor="LightSteelBlue" | '''Cardiovascular'''
+|style="height:100px"; style="width:75%" border="1" bgcolor="Beige" | No underlying causes
+|-
+|-bgcolor="LightSteelBlue"
+| '''Chemical/Poisoning'''
+|bgcolor="Beige"| [[Diterpenoids]]
+|-
+|-bgcolor="LightSteelBlue"
+| '''Dental'''
+|bgcolor="Beige"| No underlying causes
+|-
+|-bgcolor="LightSteelBlue"
+| '''Dermatologic'''
+|bgcolor="Beige"| No underlying causes
+|-
+|-bgcolor="LightSteelBlue"
+| '''Drug Side Effect'''
+|bgcolor="Beige"| [[Atazanavir sulfate]],  [[azathioprine]],  [[bexarotene]],  [[calcineurin inhibitors]],  [[chlortalidone]],  [[corticosteroids]],  [[cyclosporine]],  [[desvenlafaxine]],  [[fish oil supplementation]],  [[immunosuppressive agents]],  [[levonorgestrel]],  [[lopinavir]],  [[mycophenolate]],  [[nicotine]],  [[norgestrel]],  [[prednisone]],  [[progestin]],  [[rapamycin]],  [[rosiglitazone]],  [[sirolimus]],  [[thiazide]],  [[tocilizumab]]
+|-
+|-bgcolor="LightSteelBlue"
+| '''Ear Nose Throat'''
+|bgcolor="Beige"| No underlying causes
+|-
+|-bgcolor="LightSteelBlue"
+| '''Endocrine'''
+|bgcolor="Beige"| [[17 alpha alkylated androgens]],  [[dehydroepiandrosterone]],  [[growth hormone deficiency]],  [[hypercortisolism]],  [[hypothyroidism]],  [[poly cystic ovarian syndrome]],  [[progestagens]],  [[subclinical hypothyroidism]],  [[testosterone]]
+|-
+|-bgcolor="LightSteelBlue"
+| '''Environmental'''
+|bgcolor="Beige"| No underlying causes
+|-
+|-bgcolor="LightSteelBlue"
+| '''Gastroenterologic'''
+|bgcolor="Beige"| No underlying causes
+|-
+|-bgcolor="LightSteelBlue"
+| '''Genetic'''
+|bgcolor="Beige"| [[Acid sphingomyelinase deficiency]],  [[autosomal recessive hypercholesterolemia]],  [[familial combined hyperlipidemia]],  [[familial defective apolipoprotein B-100]],  [[familial hypercholesterolemia]],  [[hyperapobetalipoproteinemia]],  [[IL 28B polymorphisms]],  [[Niemann-pick disease]],  [[polygenic hypercholesterolemia]]
+|-
+|-bgcolor="LightSteelBlue"
+| '''Hematologic'''
+|bgcolor="Beige"| No underlying causes
+|-
+|-bgcolor="LightSteelBlue"
+| '''Iatrogenic'''
+|bgcolor="Beige"| No underlying causes
+|-
+|-bgcolor="LightSteelBlue"
+| '''Infectious Disease'''
+|bgcolor="Beige"| [[Gram negative bacillary bacteremia]],  [[H. pylori]],  [[small bowel bacterial overgrowth syndrome]],
+|-
+|-bgcolor="LightSteelBlue"
+| '''Musculoskeletal/Orthopedic'''
+|bgcolor="Beige"| No underlying causes
+|-
+|-bgcolor="LightSteelBlue"
+| '''Neurologic'''
+|bgcolor="Beige"| No underlying causes
+|-
+|-bgcolor="LightSteelBlue"
+| '''Nutritional/Metabolic'''
+|bgcolor="Beige"| [[Chenodeoxycholic acid]],  [[high carbohydrate diet]],  [[high saturated fat diet]],  [[omega-3 polyunsaturated fatty acids]],  [[polygenic hypercholesterolemia]],  [[primary hyperlipoproteinemia]],  [[primary hypolipoproteinemia type 1]],  [[selenium deficiency]]
+|-
+|-bgcolor="LightSteelBlue"
+| '''Obstetric/Gynecologic'''
+|bgcolor="Beige"| [[Polycystic ovarian syndrome]]
+|-
+|-bgcolor="LightSteelBlue"
+| '''Oncologic'''
+|bgcolor="Beige"| No underlying causes
+|-
+|-bgcolor="LightSteelBlue"
+| '''Ophthalmologic'''
+|bgcolor="Beige"| No underlying causes
+|-
+|-bgcolor="LightSteelBlue"
+| '''Overdose/Toxicity'''
+|bgcolor="Beige"| No underlying causes
+|-
+|-bgcolor="LightSteelBlue"
+| '''Psychiatric'''
+|bgcolor="Beige"| No underlying causes
+|-
+|-bgcolor="LightSteelBlue"
+| '''Pulmonary'''
+|bgcolor="Beige"| No underlying causes
+|-
+|-bgcolor="LightSteelBlue"
+| '''Renal/Electrolyte'''
+|bgcolor="Beige"| [[Chronic kidney disease]],  [[nephrotic syndrome]]
+|-
+|-bgcolor="LightSteelBlue"
+| '''Rheumatology/Immunology/Allergy'''
+|bgcolor="Beige"| [[Dysproteinemia]],  [[lipopolysaccharides]],  [[monoclonal gammopathies]],  [[paraproteinemia]]
+|-
+|-bgcolor="LightSteelBlue"
+| '''Sexual'''
+|bgcolor="Beige"| No underlying causes
+|-
+|-bgcolor="LightSteelBlue"
+| '''Trauma'''
+|bgcolor="Beige"| No underlying causes
+|-
+|-bgcolor="LightSteelBlue"
+| '''Urologic'''
+|bgcolor="Beige"| No underlying causes
+|-
+|-bgcolor="LightSteelBlue"
+| '''Miscellaneous'''
+|bgcolor="Beige"| No underlying causes
+|-
+|}
+===Causes in Alphabetical Order===
+{{col-begin|width=80%}}
+{{col-break|width=33%}}
+*[[17 alpha alkylated androgens]]
+*[[Acid sphingomyelinase deficiency]]
+*[[Atazanavir sulfate]]
+*[[Autosomal recessive hypercholesterolemia]]
+*[[Azathioprine]]
+*[[Bexarotene]]
+*[[Calcineurin inhibitors]]
+*[[Chenodeoxycholic acid]]
+*[[Chlortalidone]]
+*[[Cholestatic jaundice]]
+*[[Chronic kidney disease]]
+*[[Chronic liver disease]]
+*[[Corticosteroids]]
+*[[Cyclosporine]]
+*[[Dehydroepiandrosterone]]
+*[[Desvenlafaxine]]
+*[[Diterpenoids]]
+*[[Dysproteinemia]]
+*[[Familial combined hyperlipidemia]]
+*[[Familial defective apolipoprotein B-100]]
+*[[Familial hypercholesterolemia]]
+{{col-break|width=33%}}
+*[[Fish oil supplementation]]
+*[[Gram negative bacillary bacteremia]]
+*[[Growth hormone deficiency]]
+*[[H. pylori]]
+*[[High carbohydrate diet]]
+*[[High saturated fat diet]]
+*[[Hyperapobetalipoproteinemia]]
+*[[Hypercortisolism]]
+*[[Hypothyroidism]]
+*[[IL 28B polymorphisms]]
+*[[Immunosuppressive agents]]
+*[[LDL receptor deficiency]]
+*[[Levonorgestrel]]
+*[[Lipopolysaccharides]]
+*[[Lopinavir]]
+*[[Monoclonal gammopathies]]
+*[[Mycophenolate]]
+*[[Nephrotic syndrome]]
+*[[Nicotine]]
+*[[Niemann-pick disease]]
+*[[Norgestrel]]
+{{col-break|width=33%}}
+*[[Obstructive liver disease]]
+*[[Omega-3 polyunsaturated fatty acids]]
+*[[Pancreatitis]]
+*[[Paraproteinemia]]
+*[[Polycystic ovarian syndrome]]
+*[[Polygenic hypercholesterolemia]]
+*[[Prednisone]]
+*[[Primary biliary cirrhosis]]
+*[[Primary hyperlipoproteinemia]]
+*[[Primary hypolipoproteinemia type 1]]
+*[[Progestagens]]
+*[[Progestin]]
+*[[Rapamycin]]
+*[[Rosiglitazone]]
+*[[Selenium deficiency]]
+*[[Sirolimus]]
+*[[Small bowel bacterial overgrowth syndrome]]
+*[[Subclinical hypothyroidism]]
+*[[Testosterone]]
+*[[Thiazide]]
+*[[Tocilizumab]]
+{{col-end}}
 ==References==

High LDL causes: Difference between revisions

Revision as of 16:31, 17 September 2013

Overview

Causes

Life Threatening Causes

Common Causes

Causes by Organ System

Causes in Alphabetical Order

References

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