High chylomicron causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Hyperchylomicronemia occurs more commonly as a result of deficient lipoprotein lipase enzyme. This deficiency could either be genetic as in type I and type V hyperlipoproteinemia or due to conditions such as alcoholism, chronic renal failure, hypothyroidism, and diabetes mellitus which affect the activity of lipoprotein lipase enzyme.

Causes

Life Threatening Causes

Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated.

Hyperchylomicronemia in itself is not a life-threatening condition.

Common Causes

• Alcohol
• Chronic renal failure
• Diabetes mellitus
• Hypothyroidism
• Oral contraceptives
• Pregnancy
• Thiazide diuretics

Causes by Organ System

Cardiovascular	No underlying causes
Chemical/Poisoning	No underlying causes
Dental	No underlying causes
Dermatologic	No underlying causes
Drug Side Effect	Heparin, oral contraceptives, thiazide diuretics
Ear Nose Throat	No underlying causes
Endocrine	Diabetes mellitus, hypothyroidism
Environmental	No underlying causes
Gastroenterologic	No underlying causes
Genetic	Glycogen storage disease type I, lipoprotein lipase deficiency , type 1C hyperlipoproteinemia, mixed hyperlipoproteinemia
Hematologic	No underlying causes
Iatrogenic	No underlying causes
Infectious Disease	No underlying causes
Musculoskeletal/Orthopedic	No underlying causes
Neurologic	No underlying causes
Nutritional/Metabolic	Familial hypertriglyceridemia, glycogen storage disease type I, lipoprotein lipase deficiency
Obstetric/Gynecologic	Pregnancy
Oncologic	No underlying causes
Ophthalmologic	No underlying causes
Overdose/Toxicity	Alcohol
Psychiatric	No underlying causes
Pulmonary	No underlying causes
Renal/Electrolyte	Chronic renal failure
Rheumatology/Immunology/Allergy	Autoimmune hyperchylomicronemia
Sexual	No underlying causes
Trauma	No underlying causes
Urologic	No underlying causes
Miscellaneous	No underlying causes

Causes by Alphabetical Order

• Alcohol
• Autoimmune hyperchylomicronemia
• Chronic renal failure
• Diabetes mellitus
• Familial apolipoprotein C-II deficiency, type 1b
• Familial hypertriglyceridemia
• Glycogen storage disease type I
• Heparin
• Hypothyroidism
• Lipoprotein lipase deficiency
• Oral contraceptives
• Pregnancy
• Thiazide diuretics
• Type 1C hyperlipoproteinemia
• Mixed hyperlipoproteinemia