ARBITER 3 Trial: Difference between revisions
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==Objective== | |||
To study the effects of long term treatment with extended release niacin (ERN) on [[HDL]] levels and carotid intima- media thickness in patients who participated in ARBITER 2. | To study the effects of long term treatment with extended release niacin (ERN) on [[HDL]] levels and carotid intima- media thickness in patients who participated in ARBITER 2. | ||
==Methods== | |||
88% (149) of patients enrolled in the ARBITER trial participated in the ARBITER 3 trial, those who either were continued or crossed over to the placebo group. The long term effects of ERN on HDL cholesterol and carotid intima- media thickness were examined during 12- 24 months of treatment. | 88% (149) of patients enrolled in the ARBITER trial participated in the ARBITER 3 trial, those who either were continued or crossed over to the placebo group. The long term effects of ERN on HDL cholesterol and carotid intima- media thickness were examined during 12- 24 months of treatment. | ||
==Results== | |||
* The ERN group showed an increase in [[HDL]]-C levels along with modest reductions in [[LDL]]-C and [[triglycerides]]. | * The ERN group showed an increase in [[HDL]]-C levels along with modest reductions in [[LDL]]-C and [[triglycerides]]. | ||
* A net regression in CMIT was seen in patients treated with ENC for 12 months. | * A net regression in CMIT was seen in patients treated with ENC for 12 months. | ||
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* Changes in HDL-C were independently associated with regression of CIMT, controlling for changes in LDL and triglycerides. | * Changes in HDL-C were independently associated with regression of CIMT, controlling for changes in LDL and triglycerides. | ||
==Conclusion== | |||
ERN when added to statin therapy significantly increases HDL levels and induces [[atherosclerosis]] regression. Open label design and the inability to correlate CIMT effects to clinical outcomes were the limitations of this study.<ref name="pmid17076985">{{cite journal |author=Taylor AJ, Lee HJ, Sullenberger LE |title=The effect of 24 months of combination statin and extended-release niacin on carotid intima-media thickness: ARBITER 3 |journal=[[Current Medical Research and Opinion]] |volume=22 |issue=11 |pages=2243–50 |year=2006 |month=November |pmid=17076985 |doi=10.1185/030079906X148508 |url=}}</ref> | ERN when added to statin therapy significantly increases HDL levels and induces [[atherosclerosis]] regression. Open label design and the inability to correlate CIMT effects to clinical outcomes were the limitations of this study.<ref name="pmid17076985">{{cite journal |author=Taylor AJ, Lee HJ, Sullenberger LE |title=The effect of 24 months of combination statin and extended-release niacin on carotid intima-media thickness: ARBITER 3 |journal=[[Current Medical Research and Opinion]] |volume=22 |issue=11 |pages=2243–50 |year=2006 |month=November |pmid=17076985 |doi=10.1185/030079906X148508 |url=}}</ref> | ||
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[[Category:Lipopedia]] | [[Category:Lipopedia]] | ||
[[Category:HDL]] | [[Category:HDL]] | ||
[[Category:Clinical trials]] | |||
Revision as of 23:19, 17 September 2013
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Objective
To study the effects of long term treatment with extended release niacin (ERN) on HDL levels and carotid intima- media thickness in patients who participated in ARBITER 2.
Methods
88% (149) of patients enrolled in the ARBITER trial participated in the ARBITER 3 trial, those who either were continued or crossed over to the placebo group. The long term effects of ERN on HDL cholesterol and carotid intima- media thickness were examined during 12- 24 months of treatment.
Results
- The ERN group showed an increase in HDL-C levels along with modest reductions in LDL-C and triglycerides.
- A net regression in CMIT was seen in patients treated with ENC for 12 months.
- An additional regression was noted in patients treated with ENC for 24 months.
- Changes in HDL-C were independently associated with regression of CIMT, controlling for changes in LDL and triglycerides.
Conclusion
ERN when added to statin therapy significantly increases HDL levels and induces atherosclerosis regression. Open label design and the inability to correlate CIMT effects to clinical outcomes were the limitations of this study.[1]
References
- ↑ Taylor AJ, Lee HJ, Sullenberger LE (2006). "The effect of 24 months of combination statin and extended-release niacin on carotid intima-media thickness: ARBITER 3". Current Medical Research and Opinion. 22 (11): 2243–50. doi:10.1185/030079906X148508. PMID 17076985. Unknown parameter
|month=ignored (help)