High density lipoprotein future or investigational therapies: Difference between revisions
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==The Need== | ==The Need== | ||
The importance of increasing serum levels and functionality of HDL-C in lowering residual cardiovascular risks in patients with [[acute coronary syndrome]]s cannot be over-emphasized. First of all, some recent studies reported failures of orally active medications that increase serum levels of HDL-C to potentially improve cardiovascular outcomes, such as [[niacin]] in the [[AIM-HIGH Trial]]. This have shifted the focus of researchers to other targets of HDL therapy aimed at increasing the serum levels of HDL as well as its functionality i.e., cellular cholesterol efflux and HDL-mediated reverse cholesterol transport mechanisms. Secondly, since the available oral medications elevate HDL over weeks to months, there is the need for medications | The importance of increasing serum levels and functionality of HDL-C in lowering residual cardiovascular risks in patients with [[acute coronary syndrome]]s cannot be over-emphasized. First of all, some recent studies reported failures of orally active medications that increase serum levels of HDL-C to potentially improve cardiovascular outcomes, such as [[niacin]] in the [[AIM-HIGH Trial]]. This have shifted the focus of researchers to other targets of HDL therapy aimed at increasing the serum levels of HDL as well as its functionality i.e., cellular cholesterol efflux and HDL-mediated reverse cholesterol transport mechanisms. Secondly, since the available oral medications elevate HDL over weeks to months, there is the need for medications which rapidly improve outcomes during acute vascular events. | ||
==Cholesterol Ester Transfer Protein (CETP) Inhibition== | ==Cholesterol Ester Transfer Protein (CETP) Inhibition== | ||
Revision as of 19:47, 19 September 2013
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aarti Narayan, M.B.B.S [2]; Raviteja Guddeti, M.B.B.S. [3]
Overview
The Need
The importance of increasing serum levels and functionality of HDL-C in lowering residual cardiovascular risks in patients with acute coronary syndromes cannot be over-emphasized. First of all, some recent studies reported failures of orally active medications that increase serum levels of HDL-C to potentially improve cardiovascular outcomes, such as niacin in the AIM-HIGH Trial. This have shifted the focus of researchers to other targets of HDL therapy aimed at increasing the serum levels of HDL as well as its functionality i.e., cellular cholesterol efflux and HDL-mediated reverse cholesterol transport mechanisms. Secondly, since the available oral medications elevate HDL over weeks to months, there is the need for medications which rapidly improve outcomes during acute vascular events.
Cholesterol Ester Transfer Protein (CETP) Inhibition
Direct Infusion of Apo A-I
This involves the reconstituted and the recombinant preparations.
ApoA-1 Milano
CSL-112
CER-001
De-lipidated HDL Infusions
HDL Mimetics
ApoA-I Mimetic Peptides
- D-4F and L-4F