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* For a lot of years, HDL was thought to be as simple in structure as LDL. Insight about the complexity and heterogeneity of HDL began later on after the discovery that HDL has several constituent proteins. | * For a lot of years, HDL was thought to be as simple in structure as LDL. Insight about the complexity and heterogeneity of HDL began later on after the discovery that HDL has several constituent proteins. | ||
* The association between low HDL and cardiovacular risk factors | * In an article published in The Lancet in 1975, scientists hypothesized the association between low HDL level and high cardiovacular risk based on the finding that body cholesterol pool increases as HDL decreases.<ref name="pmid46338">{{cite journal| author=Miller GJ, Miller NE| title=Plasma-high-density-lipoprotein concentration and development of ischaemic heart-disease. | journal=Lancet | year= 1975 | volume= 1 | issue= 7897 | pages= 16-9 | pmid=46338 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=46338 }} </ref> The association between low HDL and cardiovacular risk factors was thoroughly investigated by The Framingham Heart Study and The Helsinki Heart Study.<ref name="pmid3196218">{{cite journal| author=Wilson PW, Abbott RD, Castelli WP| title=High density lipoprotein cholesterol and mortality. The Framingham Heart Study. | journal=Arteriosclerosis | year= 1988 | volume= 8 | issue= 6 | pages= 737-41 | pmid=3196218 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=3196218 }} </ref><ref name="pmid3322826">{{cite journal| author=Mänttäri M, Elo O, Frick MH, Haapa K, Heinonen OP, Heinsalmi P et al.| title=The Helsinki Heart Study: basic design and randomization procedure. | journal=Eur Heart J | year= 1987 | volume= 8 Suppl I | issue= | pages= 1-29 | pmid=3322826 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=3322826 }} </ref> | ||
==References== | ==References== | ||
Revision as of 12:46, 21 September 2013
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Historical Perspective
- HDL was the first lipoprotein to be isolated in 1929. Macheboeuf isolated what was discovered to be an alpha protein, later on referred to as HDL, from ammonium sulfate treated horse serum. [1]
- Further understanding of the nature of lipoproteins was driven by the laboratories efforts to purify blood for transfusion during World War II. During this era, lipoproteins were classified into "alpha-lipoprotein" and "beta-lipoprotein" referring to HDL and LDL respectively.[2]
- For a lot of years, HDL was thought to be as simple in structure as LDL. Insight about the complexity and heterogeneity of HDL began later on after the discovery that HDL has several constituent proteins.
- In an article published in The Lancet in 1975, scientists hypothesized the association between low HDL level and high cardiovacular risk based on the finding that body cholesterol pool increases as HDL decreases.[3] The association between low HDL and cardiovacular risk factors was thoroughly investigated by The Framingham Heart Study and The Helsinki Heart Study.[4][5]
References
- ↑ Olson RE (1998). "Discovery of the lipoproteins, their role in fat transport and their significance as risk factors". J Nutr. 128 (2 Suppl): 439S–443S. PMID 9478044.
- ↑ Gotto AM (2005). "Evolving concepts of dyslipidemia, atherosclerosis, and cardiovascular disease: the Louis F. Bishop Lecture". J Am Coll Cardiol. 46 (7): 1219–24. doi:10.1016/j.jacc.2005.06.059. PMID 16198834.
- ↑ Miller GJ, Miller NE (1975). "Plasma-high-density-lipoprotein concentration and development of ischaemic heart-disease". Lancet. 1 (7897): 16–9. PMID 46338.
- ↑ Wilson PW, Abbott RD, Castelli WP (1988). "High density lipoprotein cholesterol and mortality. The Framingham Heart Study". Arteriosclerosis. 8 (6): 737–41. PMID 3196218.
- ↑ Mänttäri M, Elo O, Frick MH, Haapa K, Heinonen OP, Heinsalmi P; et al. (1987). "The Helsinki Heart Study: basic design and randomization procedure". Eur Heart J. 8 Suppl I: 1–29. PMID 3322826.