WBR0510: Difference between revisions

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|MainCategory=Pharmacology, Physiology
|MainCategory=Pharmacology, Physiology
|SubCategory=Endocrine, Reproductive
|SubCategory=Endocrine, Reproductive
|Prompt=A pharmacist is eager to study different models in reproductive pharmacology.  He is very passionate about translational research. He is planning a study with mice in order to determine the effects of a novel drug called “Pharma-WBR”.  He knows that the drug is supposed to work in the hypothalamus, to regulate the release of different pituitary hormones.  He measures serum concentration and determines that the drug causes different changes in FSH and LH if used continuously or pulsatile.  He finds analogy of a drug existing in the market.  Which of the following drugs has a similar mechanism of action as “Pharma-WBR”?
|Prompt=A pharmacist is planning a study with mice in order to determine the effects of a novel drug called “Pharma-WBR”.  He knows that the drug is supposed to work in the hypothalamus, to regulate the release of different pituitary hormones.  He measures serum concentration and determines that the drug causes different changes in FSH and LH if used continuously or pulsatile.  He finds analogy of a drug existing in the market.  Which of the following drugs has a similar mechanism of action as “Pharma-WBR”?
|Explanation=[[Leuprolide]] is a [[GnRH ]] analog. If used in pulsatile fashion, it acts as an agonist. If used continuously, it acts as an antagonist, because it downregulates the GnRH receptor in pituitary, therefore decreasing [[FSH]] and [[LH]]. It is used continuously with flutamide to treat prostatic cancer or uterine fibroids.  It is used pulsatile in cases of infertility.  
|Explanation=[[Leuprolide]] is a [[GnRH ]] analog. If used in pulsatile fashion, it acts as an agonist. If used continuously, it acts as an antagonist, because it downregulates the GnRH receptor in pituitary, therefore decreasing [[FSH]] and [[LH]]. It is used continuously with flutamide to treat prostatic cancer or uterine fibroids.  It is used pulsatile in cases of infertility.  
<font color="MediumBlue"><font size="4">'''Educational Objective:''' </font></font>
<font color="MediumBlue"><font size="4">'''Educational Objective:''' </font></font>
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First Aid 2012 for Step 1, Reproductive-Pharmacology chapter.
First Aid 2012 for Step 1, Reproductive-Pharmacology chapter.
|AnswerA=Flutamide
|AnswerA=Flutamide
|AnswerAExp=<font color="red">'''Incorrect.'''</font> [[Flutamide]] is a nonsteroidal competitive inhibitor of androgens at the testosterone receptor used in [[prostate cancer]].
|AnswerAExp=[[Flutamide]] is a nonsteroidal competitive inhibitor of androgens at the testosterone receptor used in [[prostate cancer]].
|AnswerB=Finasteride
|AnswerB=Finasteride
|AnswerBExp=<font color="red">'''Incorrect.'''</font> [[Finasteride]] is a 5 alfa-reductase inhibitor  used to treat BPH and male-pattern baldness.
|AnswerBExp=[[Finasteride]] is a 5 alfa-reductase inhibitor  used to treat BPH and male-pattern baldness.
|AnswerC=Mifepristone
|AnswerC=Mifepristone
|AnswerCExp=<font color="red">'''Incorrect.'''</font> [[Mifepristone]] is a competitive inhibitor of progestins at the [[progesterone]] receptors. It is used to terminate [[pregnancy]] in combination with [[misoprostol]] (PGE1 analog).
|AnswerCExp=< [[Mifepristone]] is a competitive inhibitor of progestins at the [[progesterone]] receptors. It is used to terminate [[pregnancy]] in combination with [[misoprostol]] (PGE1 analog).
|AnswerD=Ketoconazol
|AnswerD=Ketoconazol
|AnswerDExp=<font color="red">'''Incorrect.'''</font> [[Ketoconazol]] is a steroid synthesis inhibitor by inhibiting desmolase, which transforms [[cholesterol]] into [[pregnenolone]].
|AnswerDExp= [[Ketoconazol]] is a steroid synthesis inhibitor by inhibiting desmolase, which transforms [[cholesterol]] into [[pregnenolone]].
|AnswerE=Leuprolide
|AnswerE=Leuprolide
|AnswerEExp=<font color="Green">'''Correct.'''</font> See overall explanation.
|AnswerEExp=See overall explanation.
|RightAnswer=E
|RightAnswer=E
|WBRKeyword=Pituitary hormones
|WBRKeyword=Pituitary hormones
|Approved=No
|Approved=No
}}
}}

Revision as of 13:03, 7 July 2014
Author [[PageAuthor::Gonzalo A. Romero, M.D. [1]]]
Exam Type ExamType::USMLE Step 1
Main Category MainCategory::Pharmacology, MainCategory::Physiology
Sub Category SubCategory::Endocrine, SubCategory::Reproductive
Prompt [[Prompt::A pharmacist is planning a study with mice in order to determine the effects of a novel drug called “Pharma-WBR”. He knows that the drug is supposed to work in the hypothalamus, to regulate the release of different pituitary hormones. He measures serum concentration and determines that the drug causes different changes in FSH and LH if used continuously or pulsatile. He finds analogy of a drug existing in the market. Which of the following drugs has a similar mechanism of action as “Pharma-WBR”?]]
Answer A AnswerA::Flutamide
Answer A Explanation [[AnswerAExp::Flutamide is a nonsteroidal competitive inhibitor of androgens at the testosterone receptor used in prostate cancer.]]
Answer B AnswerB::Finasteride
Answer B Explanation [[AnswerBExp::Finasteride is a 5 alfa-reductase inhibitor used to treat BPH and male-pattern baldness.]]
Answer C AnswerC::Mifepristone
Answer C Explanation [[AnswerCExp::< Mifepristone is a competitive inhibitor of progestins at the progesterone receptors. It is used to terminate pregnancy in combination with misoprostol (PGE1 analog).]]
Answer D AnswerD::Ketoconazol
Answer D Explanation [[AnswerDExp::Ketoconazol is a steroid synthesis inhibitor by inhibiting desmolase, which transforms cholesterol into pregnenolone.]]
Answer E AnswerE::Leuprolide
Answer E Explanation AnswerEExp::See overall explanation.
Right Answer RightAnswer::E
Explanation [[Explanation::Leuprolide is a GnRH analog. If used in pulsatile fashion, it acts as an agonist. If used continuously, it acts as an antagonist, because it downregulates the GnRH receptor in pituitary, therefore decreasing FSH and LH. It is used continuously with flutamide to treat prostatic cancer or uterine fibroids. It is used pulsatile in cases of infertility.

Educational Objective:

  1. Leuprolide is a GrRH analog, which acts on the pituitary.
  2. If used continously it decreases FSH and LH. If used in a pulsatile fashion it increases FSH and LH levels.

References: First Aid 2012 for Step 1, Reproductive-Pharmacology chapter.
Educational Objective:
References: ]]

Approved Approved::No
Keyword WBRKeyword::Pituitary hormones
Linked Question Linked::
Order in Linked Questions LinkedOrder::
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