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Rim Halaby (talk | contribs) Created page with "{{WBRQuestion |QuestionAuthor={{Rim}} |ExamType=USMLE Step 1 |MainCategory=Biochemistry |SubCategory=Neurology |MainCategory=Biochemistry |SubCategory=Neurology |MainCategory=..." |
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|SubCategory=Neurology | |SubCategory=Neurology | ||
|Prompt=A researcher is investigating the regulatory neurotransmitters in the basal ganglia. In his experiment, the researcher sends high frequency electrical impulses into specific areas of the brain of a rat and measures the change in the local concentration of several neurotransmitters. Upon stimulation of the caudate, an increase in the release of a neurotransmitter is detected. The released neurotransmitter is known to inhibit the globus pallidus internus. Which amino acid is the released neurotransmitter derived from? | |Prompt=A researcher is investigating the regulatory neurotransmitters in the basal ganglia. In his experiment, the researcher sends high frequency electrical impulses into specific areas of the brain of a rat and measures the change in the local concentration of several neurotransmitters. Upon stimulation of the caudate, an increase in the release of a neurotransmitter is detected. The released neurotransmitter is known to inhibit the globus pallidus internus. Which amino acid is the released neurotransmitter derived from? | ||
|Explanation=The caudate is | |Explanation=The [[caudate]] is involved in the direct and indirect pathway of the fine tuning of motor activity. The caudate is physiologically stimulated by [[glutamate]] released from the motor cortex. Stimulation of the caudate, physiologically or experimentally, will likely lead to the release of [[GABA]]. GABA is an inhibitory neurotransmitter derived from [[glutamate]]. The synthesis of GABA requires [[vitamin B6]]. | ||
Education objective: | Education objective: | ||
GABA is derived from | |||
[[GABA]] is derived from [[glutamate]]. | |||
|AnswerA=Tryptophan | |AnswerA=Tryptophan | ||
|AnswerAExp=Tryptophan is not a precursor for GABA. | |AnswerAExp=[[Tryptophan]] is not a precursor for GABA. | ||
|AnswerB=Glycine | |AnswerB=Glycine | ||
|AnswerBExp= | |AnswerBExp=[[Glycine]] is not a precursor for GABA. | ||
|AnswerC=Glutamate | |AnswerC=Glutamate | ||
|AnswerCExp=Glutamate is the precursor for GABA, the synthesis of which requires vitamin B6. | |AnswerCExp=Glutamate is the precursor for GABA, the synthesis of which requires vitamin B6. | ||
|AnswerD=Arginine | |AnswerD=Arginine | ||
|AnswerDExp= | |AnswerDExp=[[Arginine]] is not a precursor for GABA. | ||
|AnswerE=Lysine | |AnswerE=Lysine | ||
|AnswerEExp= | |AnswerEExp=[[Lysine]] is not a precursor for GABA. | ||
|RightAnswer=C | |RightAnswer=C | ||
|WBRKeyword=Basal ganglia, GABA, glycine | |WBRKeyword=Basal ganglia, GABA, glycine | ||
|Approved=No | |Approved=No | ||
}} | }} | ||
Revision as of 23:16, 6 October 2013
| Author | [[PageAuthor::Rim Halaby, M.D. [1]]] |
|---|---|
| Exam Type | ExamType::USMLE Step 1 |
| Main Category | MainCategory::Biochemistry |
| Sub Category | SubCategory::Neurology |
| Prompt | [[Prompt::A researcher is investigating the regulatory neurotransmitters in the basal ganglia. In his experiment, the researcher sends high frequency electrical impulses into specific areas of the brain of a rat and measures the change in the local concentration of several neurotransmitters. Upon stimulation of the caudate, an increase in the release of a neurotransmitter is detected. The released neurotransmitter is known to inhibit the globus pallidus internus. Which amino acid is the released neurotransmitter derived from?]] |
| Answer A | AnswerA::Tryptophan |
| Answer A Explanation | [[AnswerAExp::Tryptophan is not a precursor for GABA.]] |
| Answer B | AnswerB::Glycine |
| Answer B Explanation | [[AnswerBExp::Glycine is not a precursor for GABA.]] |
| Answer C | AnswerC::Glutamate |
| Answer C Explanation | AnswerCExp::Glutamate is the precursor for GABA, the synthesis of which requires vitamin B6. |
| Answer D | AnswerD::Arginine |
| Answer D Explanation | [[AnswerDExp::Arginine is not a precursor for GABA.]] |
| Answer E | AnswerE::Lysine |
| Answer E Explanation | [[AnswerEExp::Lysine is not a precursor for GABA.]] |
| Right Answer | RightAnswer::C |
| Explanation | [[Explanation::The caudate is involved in the direct and indirect pathway of the fine tuning of motor activity. The caudate is physiologically stimulated by glutamate released from the motor cortex. Stimulation of the caudate, physiologically or experimentally, will likely lead to the release of GABA. GABA is an inhibitory neurotransmitter derived from glutamate. The synthesis of GABA requires vitamin B6.
Education objective: GABA is derived from glutamate. |
| Approved | Approved::No |
| Keyword | WBRKeyword::Basal ganglia, WBRKeyword::GABA, WBRKeyword::glycine |
| Linked Question | Linked:: |
| Order in Linked Questions | LinkedOrder:: |