Low LDL causes: Difference between revisions
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==Overview== | ==Overview== | ||
Lower LDL cholesterol can be associated with an enhanced tendency to develop [[Non-alcoholic fatty liver disease|fatty liver disease]], but it is also associated with a substantially greater reduction in the risk of [[CHD]]. Unusual inherited disorders of lipoprotein metabolism are usually associated with low LDL levels. | |||
==Causes== | ==Causes== | ||
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===Common Causes=== | ===Common Causes=== | ||
*[[Abetalipoproteinemia]] | |||
*[[Hypobetalipoproteinemia]]<ref name="Scanu-1974">{{Cite journal | last1 = Scanu | first1 = AM. | last2 = Aggerbeck | first2 = LP. | last3 = Kruski | first3 = AW. | last4 = Lim | first4 = CT. | last5 = Kayden | first5 = HJ. | title = A study of the abnormal lipoproteins in abetalipoproteinemia. | journal = J Clin Invest | volume = 53 | issue = 2 | pages = 440-53 | month = Feb | year = 1974 | doi = 10.1172/JCI107578 | PMID = 11344558 }}</ref><ref name="Welty-1997">{{Cite journal | last1 = Welty | first1 = FK. | last2 = Mittleman | first2 = MA. | last3 = Wilson | first3 = PW. | last4 = Sutherland | first4 = PA. | last5 = Matheney | first5 = TH. | last6 = Lipinska | first6 = I. | last7 = Muller | first7 = JE. | last8 = Levy | first8 = D. | last9 = Tofler | first9 = GH. | title = Hypobetalipoproteinemia is associated with low levels of hemostatic risk factors in the Framingham offspring population. | journal = Circulation | volume = 95 | issue = 4 | pages = 825-30 | month = Feb | year = 1997 | doi = | PMID = 9054738 }}</ref> | |||
===Causes by Organ System=== | ===Causes by Organ System=== | ||
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| '''Iatrogenic''' | | '''Iatrogenic''' | ||
|bgcolor="Beige"| [[Portosystemic shunts]], [[ | |bgcolor="Beige"| [[Transjugular intrahepatic portosystemic shunt|Portosystemic shunts]], [[short bowel syndrome]] | ||
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|-bgcolor="LightSteelBlue" | |-bgcolor="LightSteelBlue" | ||
| '''Nutritional/Metabolic''' | | '''Nutritional/Metabolic''' | ||
|bgcolor="Beige"| [[Abetalipoproteinemia]], [[apolipoprotein B deficiency]], [[Bassen-Kornzweig disease]], [[familial alphalipoprotein deficiency]], [[familial hypobetalipoproteinemia]], [[hyperlipoproteinemia, familial type 5]], [[hypobetalipoproteinemia]], [[lipoprotein lipase deficiency]], [[mutations of the MTTP gene]] | |bgcolor="Beige"| [[Abetalipoproteinemia]], [[apolipoprotein B deficiency]], [[Abetalipoproteinemia|Bassen-Kornzweig disease]], [[familial alphalipoprotein deficiency]], [[familial hypobetalipoproteinemia]], [[Hyperlipoproteinemia|hyperlipoproteinemia, familial type 5]], [[hypobetalipoproteinemia]], [[lipoprotein lipase deficiency]], [[Abetalipoproteinemia|mutations of the MTTP gene]] | ||
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| '''Rheumatology/Immunology/Allergy''' | | '''Rheumatology/Immunology/Allergy''' | ||
|bgcolor="Beige"| [[Acute phase proteins]], [[amyloidosis]], [[autoimmune diseases]], [[celiac disease]], [[inflammatory cytokines]], [[serum amyloid A]], [[ | |bgcolor="Beige"| [[Acute phase proteins]], [[amyloidosis]], [[autoimmune diseases]], [[celiac disease]], [[Cytokine|inflammatory cytokines]], [[serum amyloid A]], [[Sjögren's syndrome]] | ||
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|-bgcolor="LightSteelBlue" | |-bgcolor="LightSteelBlue" | ||
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*[[Hyperlipoproteinemia|Hyperlipoproteinemia, familial type 5]] | *[[Hyperlipoproteinemia|Hyperlipoproteinemia, familial type 5]] | ||
*[[Hypobetalipoproteinemia]] | *[[Hypobetalipoproteinemia]] | ||
*[[Inflammatory cytokines]] | *[[Cytokine|Inflammatory cytokines]] | ||
*[[Lymphangiectasia|Intestinal lymphangiectasia]] | *[[Lymphangiectasia|Intestinal lymphangiectasia]] | ||
*[[Ketogenic diet]] | *[[Ketogenic diet]] | ||
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*[[Short bowel syndrome]] | *[[Short bowel syndrome]] | ||
*[[Shwachman-Diamond syndrome]] | *[[Shwachman-Diamond syndrome]] | ||
*[[ | *[[Sjögren's syndrome]] | ||
*[[Statins]] | *[[Statins]] | ||
{{col-end}} | {{col-end}} | ||
Revision as of 21:02, 6 November 2013
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Low LDL causes On the Web |
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American Roentgen Ray Society Images of Low LDL causes |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Cafer Zorkun, M.D., Ph.D. [2]; Rim Halaby, M.D. [3]; Vendhan Ramanujam M.B.B.S [4]
Overview
Lower LDL cholesterol can be associated with an enhanced tendency to develop fatty liver disease, but it is also associated with a substantially greater reduction in the risk of CHD. Unusual inherited disorders of lipoprotein metabolism are usually associated with low LDL levels.
Causes
Life Threatening Causes
Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated.
Common Causes
Causes by Organ System
Causes in Alphabetical Order
References
- ↑ Scanu, AM.; Aggerbeck, LP.; Kruski, AW.; Lim, CT.; Kayden, HJ. (1974). "A study of the abnormal lipoproteins in abetalipoproteinemia". J Clin Invest. 53 (2): 440–53. doi:10.1172/JCI107578. PMID 11344558. Unknown parameter
|month=ignored (help) - ↑ Welty, FK.; Mittleman, MA.; Wilson, PW.; Sutherland, PA.; Matheney, TH.; Lipinska, I.; Muller, JE.; Levy, D.; Tofler, GH. (1997). "Hypobetalipoproteinemia is associated with low levels of hemostatic risk factors in the Framingham offspring population". Circulation. 95 (4): 825–30. PMID 9054738. Unknown parameter
|month=ignored (help)