Meropenem: Difference between revisions
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'''| [[Meropenem dosage and administration|Dosage and Administration]]''' | '''| [[Meropenem dosage and administration|Dosage and Administration]]''' | ||
'''| [[Meropenem compatibility reconstitution and stability|Compatibility, Reconstitution, and Stability]]''' | '''| [[Meropenem compatibility reconstitution and stability|Compatibility, Reconstitution, and Stability]]''' | ||
'''| [[Meropenem how supplied|How Supplied]]''' | '''| [[Meropenem how supplied|How Supplied]]''' | ||
'''| [[Meropenem labels and packages|Labels and Packages]]''' | '''| [[Meropenem labels and packages|Labels and Packages]]''' | ||
Revision as of 15:25, 23 December 2013
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Meropenem is an ultra-broad spectrum injectable antibiotic used to treat a wide variety of infections, including meningitis and pneumonia. It is a beta-lactam and belongs to the subgroup of carbapenem, similar to imipenem and ertapenem. Meropenem gained FDA approval in July 1996. It penetrates well into many tissues and body fluids including the cerebrospinal fluid,bile, heart valves, lung, and peritoneal fluid.[1]
Category
Carbapenems
US Brand Names
Merrem®
FDA Package Insert
Description | Clinical Pharmacology | Microbiology | Indications and Usage | Contraindications | Warnings | Precautions | Adverse Reactions | Overdosage | Clinical Studies | Dosage and Administration | Compatibility, Reconstitution, and Stability | How Supplied | Labels and Packages
Mechanism of action
Meropenem is bactericidal except against Listeria monocytogenes where it is bacteriostatic. It inhibits bacterial wall synthesis like other beta-lactam antibiotics. In contrast to other beta-lactams, it is highly resistant to degradation by beta-lactamase or cephalosporinase. Resistance generally arises due to mutations in penicillin binding proteins, production of metallo-beta-lactamases, or resistance to diffusion across the bacterial outer membrane.[2] Unlike imipenem, it is stable to dehydropeptidase-1 and can therefore be given without cilastatin.