Capreomycin sulfate: Difference between revisions
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==Mechanism of Action== | ==Mechanism of Action== | ||
Capreomycin is a cyclic polypeptide antimycobacterial agent. The mechanism of action of capreomycin is postulated to interfere with several ribosomal functions including formation of the 30S subunit initiation complex and blockade of tRNA translocation from the A to the P site. Significant cross-resistance with [[viomycin]], [[kanamycin]], and [[neomycin]] occurs. | Capreomycin is a cyclic polypeptide antimycobacterial agent. The mechanism of action of capreomycin is postulated to interfere with several ribosomal functions including formation of the 30S subunit initiation complex and blockade of tRNA translocation from the A to the P site.<ref name="Johansen-2006">{{Cite journal | last1 = Johansen | first1 = SK. | last2 = Maus | first2 = CE. | last3 = Plikaytis | first3 = BB. | last4 = Douthwaite | first4 = S. | title = Capreomycin binds across the ribosomal subunit interface using tlyA-encoded 2'-O-methylations in 16S and 23S rRNAs. | journal = Mol Cell | volume = 23 | issue = 2 | pages = 173-82 | month = Jul | year = 2006 | doi = 10.1016/j.molcel.2006.05.044 | PMID = 16857584 }}</ref> Significant cross-resistance with [[viomycin]], [[kanamycin]], and [[neomycin]] occurs. | ||
==References== | ==References== | ||
Revision as of 02:15, 26 December 2013
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Capreomycin is a peptide antibiotic, commonly grouped with the aminoglycosides, which is given in combination with other antibiotics for MDR-tuberculosis. Adverse effects include nephrotoxicity and 8th cranial auditory vestibular nerve nerve toxicity.
Category
Antimycobacterial
US Brand Names
CAPASTAT SULFATE®
FDA Package Insert
Description | Clinical Pharmacology | Microbiology | Indications and Usage | Contraindications | Warnings and Precautions | Adverse Reactions | Overdosage | Dosage and Administration | How Supplied | Labels and Packages
Mechanism of Action
Capreomycin is a cyclic polypeptide antimycobacterial agent. The mechanism of action of capreomycin is postulated to interfere with several ribosomal functions including formation of the 30S subunit initiation complex and blockade of tRNA translocation from the A to the P site.[1] Significant cross-resistance with viomycin, kanamycin, and neomycin occurs.
References
- ↑ Johansen, SK.; Maus, CE.; Plikaytis, BB.; Douthwaite, S. (2006). "Capreomycin binds across the ribosomal subunit interface using tlyA-encoded 2'-O-methylations in 16S and 23S rRNAs". Mol Cell. 23 (2): 173–82. doi:10.1016/j.molcel.2006.05.044. PMID 16857584. Unknown parameter
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