Ethambutol: Difference between revisions
No edit summary |
Gerald Chi (talk | contribs) |
||
| Line 19: | Line 19: | ||
'''| [[Ethambutol hydrochloride warnings and precautions|Warnings and Precautions]]''' | '''| [[Ethambutol hydrochloride warnings and precautions|Warnings and Precautions]]''' | ||
'''| [[Ethambutol hydrochloride adverse reactions|Adverse Reactions]]''' | '''| [[Ethambutol hydrochloride adverse reactions|Adverse Reactions]]''' | ||
'''| [[Ethambutol hydrochloride dosage and administration|Dosage and Administration]]''' | '''| [[Ethambutol hydrochloride dosage and administration|Dosage and Administration]]''' | ||
'''| [[Ethambutol hydrochloride how supplied|How Supplied]]''' | '''| [[Ethambutol hydrochloride how supplied|How Supplied]]''' | ||
Revision as of 02:50, 31 December 2013
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Chetan Lokhande, M.B.B.S [2]
Overview
Ethambutol (commonly abbreviated EMB or simply E) is a bacteriostatic antimycobacterial drug prescribed to treat tuberculosis.[1] It is usually given in combination with other tuberculosis drugs, such as isoniazid, rifampicin and pyrazinamide.
Category
Antimycobacterial
US Brand Names
MYAMBUTOL®
FDA Package Insert
Description | Clinical Pharmacology | Indications and Usage | Contraindications | Warnings and Precautions | Adverse Reactions | Dosage and Administration | How Supplied | Labels and Packages
Mechanism of action
Ethambutol is bacteriostatic against actively growing TB bacilli. It works by obstructing the formation of cell wall. Mycolic acids attach to the 5'-hydroxyl groups of D-arabinose residues of arabinogalactan and form mycolyl-arabinogalactan-peptidoglycan complex in the cell wall. It disrupts arabinogalactan synthesis by inhibiting the enzyme arabinosyl transferase. Disruption of the arabinogalactan synthesis inhibits the formation of this complex and leads to increased permeability of the cell wall.
References
- ↑ Yendapally R, Lee RE (2008). "Design, synthesis, and evaluation of novel ethambutol analogues". Bioorg. Med. Chem. Lett. 18 (5): 1607–11. doi:10.1016/j.bmcl.2008.01.065. PMC 2276401. PMID 18242089. Unknown parameter
|month=ignored (help)