Iodoquinol: Difference between revisions

Revision as of 22:02, 30 December 2013

Iodoquinol
YODOXIN^® Package Insert
Description
Inactive Ingredients
Action
Indications
Contraindications
Warnings
Use in Pregnancy
Precautions
Adverse Reactions
Dosage and Administration
How Supplied
Storage

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

The quinoline derivative diiodohydroxyquinoline (INN) or iodoquinol (USAN) can be used in the treatment of amebiasis, balantidiasis, and Dientamoeba fragilis.^[1] It is poorly absorbed from the gastrointestinal tract and is used as a luminal agent to eradicate both cysts and trophozoites infestating the lumen of the gastrointestinal tract.

US Brand Names

ALA-SEPTIC^®, ALCORTIN^®, ALCORTIN A^®, ALOQUIN^®, DERMAZENE^®, HYDROCORTISONE IODOQUINOL cream^®, VYTONE cream^®

FDA Package Insert

Mechanisms of Action

Iodoquinol acts by chelation of Fe²⁺ which is essential for metabolism.

References

↑ Ghaskadbi S, Vaidya VG (1989). "In vivo antimutagenic effect of ascorbic acid against mutagenicity of the common antiamebic drug diiodohydroxyquinoline". Mutat. Res. 222 (3): 219–22. doi:10.1016/0165-1218(89)90137-7. PMID 2493578. Unknown parameter |month= ignored (help)

[pmid2493578-1] Ghaskadbi S, Vaidya VG (1989). "In vivo antimutagenic effect of ascorbic acid against mutagenicity of the common antiamebic drug diiodohydroxyquinoline". Mutat. Res. 222 (3): 219–22. doi:10.1016/0165-1218(89)90137-7. PMID 2493578. Unknown parameter |month= ignored (help)

[1]

@@ Line 4: / Line 4: @@
 ==Overview==
-The [[quinoline]] derivative diiodohydroxyquinoline ([[International Nonproprietary Name|INN]]) or iodoquinol ([[United States Adopted Name|USAN]]) can be used in the treatment of [[amoebiasis]].<ref name="pmid2493578">{{cite journal |author=Ghaskadbi S, Vaidya VG |title=In vivo antimutagenic effect of ascorbic acid against mutagenicity of the common antiamebic drug diiodohydroxyquinoline |journal=Mutat. Res. |volume=222 |issue=3 |pages=219–22 |year=1989 |month=March |pmid=2493578 |doi= 10.1016/0165-1218(89)90137-7|url=}}</ref> It is poorly absorbed from the [[gastrointestinal tract]] and is used as a luminal amebicide. It was discovered by Adco Co. and introduced as diiodohydroxyquinoline.<ref>Page 1312. http://books.google.co.in/books?id=TIu28TH_iAYC&printsec=frontcover&source=gbs_ge_summary_r&cad=0#v=onepage&q&f=false</ref> Susceptibility of ''[[Dientamoeba fragilis]]'' has been measured.<ref name="pmid8067755">{{cite journal |author=Chan FT, Guan MX, Mackenzie AM, Diaz-Mitoma F |title=Susceptibility testing of Dientamoeba fragilis ATCC 30948 with iodoquinol, paromomycin, tetracycline, and metronidazole |journal=Antimicrob. Agents Chemother. |volume=38 |issue=5 |pages=1157–60 |year=1994 |month=May |pmid=8067755 |pmc=188168 |doi= |url=http://aac.asm.org/cgi/pmidlookup?view=long&pmid=8067755}}</ref>
+The [[quinoline]] derivative diiodohydroxyquinoline ([[International Nonproprietary Name|INN]]) or iodoquinol ([[United States Adopted Name|USAN]]) can be used in the treatment of ''[[amebiasis]]'', ''[[balantidiasis]]'', and ''[[Dientamoeba fragilis]]''.<ref name="pmid2493578">{{cite journal |author=Ghaskadbi S, Vaidya VG |title=In vivo antimutagenic effect of ascorbic acid against mutagenicity of the common antiamebic drug diiodohydroxyquinoline |journal=Mutat. Res. |volume=222 |issue=3 |pages=219–22 |year=1989 |month=March |pmid=2493578 |doi= 10.1016/0165-1218(89)90137-7|url=}}</ref> It is poorly absorbed from the [[gastrointestinal tract]] and is used as a luminal agent to eradicate both [[cyst]]s and [[trophozoite]]s infestating the lumen of the gastrointestinal tract.
 ==Category==
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 ==Mechanisms of Action==
-Iodoquinol acts by [[chelation]] of Fe<sup>2+</sup> which is essential for metabolism.<ref>{{cite web|url=http://web.gideononline.com/web/therapy/index.php?type=drugs&code=20130&view=General |work=Gideon Online}}</ref>
+Iodoquinol acts by [[chelation]] of Fe<sup>2+</sup> which is essential for metabolism.
 ==References==