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| {{drugbox | | __NOTOC__ |
| | IUPAC_name = 4,4-difluoro-''N''-{(1''S'')-3-[3-(3-isopropyl-5-methyl-4''H''-1,2,4-triazol-4-yl)-
| | {{Maraviroc}} |
| 8-azabicyclo[3.2.1]oct-8-yl]-1-phenylpropyl}cyclohexanecarboxamide
| | {{CMG}} |
| | image = Maraviroc.svg
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| | CAS_number = 376348-65-1
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| | ATC_prefix = J05
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| | ATC_suffix = AX09
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| | PubChem = 3002977
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| | DrugBank =
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| | C=29|H=41|F=2|N=5|O=1
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| | molecular_weight = 513.666 g/mol
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| | bioavailability =
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| | protein_bound =
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| | metabolism =
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| | elimination_half-life =
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| | excretion =
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| | pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
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| | pregnancy_US = <!-- A / B / C / D / X -->
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| | pregnancy_category=
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| | legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 -->
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| | legal_CA = <!-- / Schedule I, II, III, IV, V, VI, VII, VIII -->
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| | legal_UK = <!-- GSL / P / POM / CD / Class A, B, C -->
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| | legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V -->
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| | legal_status =
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| | routes_of_administration =
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| }} | |
| [[Maraviroc]] (brand-named '''Selzentry''', or '''Celsentri''' outside the U.S.) is a [[chemokine]] [[receptor antagonist]] drug developed by the drug company [[Pfizer]] that is designed to act against [[HIV]] by interfering with the interaction between HIV and [[CCR5]]. It was originally labelled as UK-427857 during development but was assigned the Maraviroc name as it entered trials. As of early 2007, it was undergoing [[clinical trial]]s using the [[Trofile]] assay to determine participants' [[tropism]].
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| On [[April 24]] [[2007]] the U.S. [[Food and Drug Administration]] advisory panel reviewing maraviroc's [[New Drug Application]] unanimously recommended approval for the new drug.<ref>http://365gay.com/Newscon07/04/042407hiv.htm</ref>
| | ==Overview== |
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| On [[August 6]] [[2007]], the FDA granted accelerated approval of this compound.<ref>{{cite web |url=http://www.reuters.com/article/ousiv/idUSN0642522320070806 |title=Pfizer wins U.S. approval for new HIV drug | Reuters |accessdate=2007-08-06 |format= |work=}}</ref>
| | ==Category== |
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| On [[September 24]], [[2007]], [[Pfizer Inc.]] announced that the [[European Commission]] approved Celsentri ([[generic]] [[name]], maraviroc and as [[Selzentry]] in the [[United States]]). [[Industry]] [[experts]] did [[forecast]] annual Celsentri [[sales]] of $500 million by [[2011]].<ref>[http://www.reuters.com/article/governmentFilingsNews/idUSL2354082520070924 Reuters, Europe gives final approval to Pfizer HIV drug]</ref>
| | ==US Brand Names== |
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| | ==FDA Package Insert== |
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| | ''' [[Maraviroc description|Description]]''' |
| | '''| [[Maraviroc clinical pharmacology|Clinical Pharmacology]]''' |
| | '''| [[Maraviroc microbiology|Microbiology]]''' |
| | '''| [[Maraviroc indications and usage|Indications and Usage]]''' |
| | '''| [[Maraviroc contraindications|Contraindications]]''' |
| | '''| [[Maraviroc warnings and precautions|Warnings and Precautions]]''' |
| | '''| [[Maraviroc adverse reactions|Adverse Reactions]]''' |
| | '''| [[Maraviroc drug interactions|Drug Interactions]]''' |
| | '''| [[Maraviroc overdosage|Overdosage]]''' |
| | '''| [[Maraviroc clinical studies|Clinical Studies]]''' |
| | '''| [[Maraviroc dosage and administration|Dosage and Administration]]''' |
| | '''| [[Maraviroc how supplied|How Supplied]]''' |
| | '''| [[Maraviroc labels and packages|Labels and Packages]]''' |
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| | ==Mechanism of Action== |
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| ==References== | | ==References== |
| <references/>
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| == External links ==
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| * BBC News story: [http://news.bbc.co.uk/1/hi/health/6404477.stm Drug 'stops HIV's entry to cells']
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| * [http://www.aidsmap.com/cms1032246.asp Maraviroc data at aidsmap]
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| *[http://www.maraviroceap.com/default.aspx Maraviroc early access program]
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| *[http://www.usatoday.com/news/health/2007-04-24-2624448028_x.htm New HIV Drug Recommended for Approval]
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| *{{MeshName|maraviroc}}
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| {{Antivirals}} | | {{Reflist|2}} |
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| {{antimicrobial-stub}}
| | [[Category:Antibiotics]] |
| [[Category:Antiretroviral drugs]] | | [[Category:Wikinfect]] |
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| {{WikiDoc Sources}}
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