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{{ | {{CMG}}; {{AE}}; {{chetan}} | ||
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== | ==Definition== | ||
Acetaaminophen is widely used as a pain medication in the U.S . An overdose normally occurs when somebody ingests it accidentally or intentionally above the normal recommended dose . It one of the most common poisoning in the U.S and worldwide . The main reason of this being that is is easily available and people think that it is a very safe medication . It is available in the U.S market under the following brand names . | |||
*[[Tylenol]] | |||
*Anacin-3 | |||
*Liquiprin | |||
*Percocet | |||
*Tempra | |||
*Cold and flu medicines. | |||
*Aceta | |||
*Actimin | |||
*Apacet | |||
*Aspirin Free Anacin | |||
*Atasol | |||
*Banesin | |||
*Dapa | |||
*Datril Extra-Strength | |||
*Feverall | |||
*Fibi | |||
*Genapap | |||
*Genebs, | |||
*[[Panadol]] | |||
===Common dosage forms and strengths=== | |||
#Suppository: 120 mg, 125 mg, 325 mg, 650 mg | |||
#Chewable tablets: 80 mg | |||
#Regular strength: 325 mg | |||
#Extra strength: 500 mg | |||
#Liquid: 160 mg/teaspoon | |||
#Drops: 100 mg / mL, 120 mg / 2.5 mL | |||
'''mg = milligrams''' | |||
Maximum advisable dosage is 4000 mg of acetaminophen a day . A severe overdose can happen if taken more than 7000 mg / day . | |||
==Causes/Pathophysiology== | |||
After ingestion of an excessive amount of acetaminophen a toxic metabolite called '''N-acetyl-p-benzoquinonimine (NAPQI)''' is formed in excess and hence the normal pathways of conjugating by glutathione are saturated . This results in glutathione depletion which leads to liver injury . | |||
==Management== | |||
Most of the patients who have an overdose of acetaminophen are asymptomatic . A few however who are symptomatic show symptoms only after 12 hrs of ingestion. | |||
==References== | |||
[[Category:Toxicology]] | |||
[[Category:Medicine]] | |||
[[Category:Primary care]] | |||
[[Category:Resident survival guide]] | |||
{{WikiDoc Help Menu}} | |||
{{WikiDoc Sources}} | |||
Revision as of 17:11, 10 January 2014
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: ; Chetan Lokhande, M.B.B.S [2]
Definition
Acetaaminophen is widely used as a pain medication in the U.S . An overdose normally occurs when somebody ingests it accidentally or intentionally above the normal recommended dose . It one of the most common poisoning in the U.S and worldwide . The main reason of this being that is is easily available and people think that it is a very safe medication . It is available in the U.S market under the following brand names .
- Tylenol
- Anacin-3
- Liquiprin
- Percocet
- Tempra
- Cold and flu medicines.
- Aceta
- Actimin
- Apacet
- Aspirin Free Anacin
- Atasol
- Banesin
- Dapa
- Datril Extra-Strength
- Feverall
- Fibi
- Genapap
- Genebs,
- Panadol
Common dosage forms and strengths
- Suppository: 120 mg, 125 mg, 325 mg, 650 mg
- Chewable tablets: 80 mg
- Regular strength: 325 mg
- Extra strength: 500 mg
- Liquid: 160 mg/teaspoon
- Drops: 100 mg / mL, 120 mg / 2.5 mL
mg = milligrams
Maximum advisable dosage is 4000 mg of acetaminophen a day . A severe overdose can happen if taken more than 7000 mg / day .
Causes/Pathophysiology
After ingestion of an excessive amount of acetaminophen a toxic metabolite called N-acetyl-p-benzoquinonimine (NAPQI) is formed in excess and hence the normal pathways of conjugating by glutathione are saturated . This results in glutathione depletion which leads to liver injury .
Management
Most of the patients who have an overdose of acetaminophen are asymptomatic . A few however who are symptomatic show symptoms only after 12 hrs of ingestion.