Ciclopirox: Difference between revisions

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m Changed protection level for "Ciclopirox" ([Edit=Allow only autoconfirmed users] (expires 02:08, 19 January 2014 (UTC)) [Move=Allow only autoconfirmed users] (expires 02:08, 19 January 2014 (UTC)))
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{{drugbox
__NOTOC__
| IUPAC_name = 6-cyclohexyl-1-hydroxy-4-methyl-pyridin-2-one
{{XXXXX}}
| image = Ciclopirox.svg
{{CMG}}
| width = 180
 
| CAS_number = 29342-05-0
==Overview==
| ATC_prefix = D01
 
| ATC_suffix = AE14
==Category==
| ATC_supplemental = {{ATC|G01|AX12}}
 
| PubChem = 2749
==US Brand Names==
| DrugBank = APRD00871
 
| C = 12 | H = 17 | N = 1 | O = 2
==FDA Package Insert==
| molecular_weight = 207.269 g/mol
 
| bioavailability = <5% with prolonged use
'''  [[XXXXX description|Description]]'''
| protein_bound = 94 to 97%
'''| [[XXXXX clinical pharmacology|Clinical Pharmacology]]'''
| metabolism =  
'''| [[XXXXX microbiology|Microbiology]]'''
| elimination_half-life = 1.7 hours
'''| [[XXXXX indications and usage|Indications and Usage]]'''
| pregnancy_category =
'''| [[XXXXX contraindications|Contraindications]]'''
| legal_US = Rx-only
'''| [[XXXXX warnings and precautions|Warnings and Precautions]]'''
| legal_status = OTC<small>([[Canada|CA]])</small>
'''| [[XXXXX adverse reactions|Adverse Reactions]]'''
| routes_of_administration = Topical (applied as a nail lacquer)
'''| [[XXXXX drug interactions|Drug Interactions]]'''
}}
'''| [[XXXXX overdosage|Overdosage]]'''
'''Ciclopirox olamine''' (also called '''Loprox®''', '''Penlac®''' and '''Stieprox®''') is a synthetic [[antifungal]] agent for topical [[dermatology|dermatologic]] use.
'''| [[XXXXX clinical studies|Clinical Studies]]'''
It acts by inhibiting the membrane transfer system by interrupting the [[Na+/K+-ATPase|Na<sup>+</sup> K<sup>+</sup> ATPase]].<ref name="pmid12760852">{{cite journal |author=Niewerth M, Kunze D, Seibold M, Schaller M, Korting HC, Hube B |title=Ciclopirox olamine treatment affects the expression pattern of Candida albicans genes encoding virulence factors, iron metabolism proteins, and drug resistance factors |journal=Antimicrob. Agents Chemother. |volume=47 |issue=6 |pages=1805-17 |year=2003 |pmid=12760852 |doi=}}</ref>
'''| [[XXXXX dosage and administration|Dosage and Administration]]'''
'''| [[XXXXX how supplied|How Supplied]]'''
'''| [[XXXXX labels and packages|Labels and Packages]]'''
 
==Mechanism of Action==


==References==
==References==
<references/>
{{Reflist|2}}


{{antimicrobial-stub}}
[[Category:Antibiotics]]
{{Antifungals}}
[[Category:Wikinfect]]
{{Gynecological anti-infectives and antiseptics}}
[[Category:Antifungals]]
{{WikiDoc Help Menu}}

Revision as of 00:23, 6 January 2014


Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Category

US Brand Names

FDA Package Insert

Description | Clinical Pharmacology | Microbiology | Indications and Usage | Contraindications | Warnings and Precautions | Adverse Reactions | Drug Interactions | Overdosage | Clinical Studies | Dosage and Administration | How Supplied | Labels and Packages

Mechanism of Action

References

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