Cefazolin sodium: Difference between revisions
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'''| [[Cefazolin sodium warnings and precautions|Warnings and Precautions]]''' | '''| [[Cefazolin sodium warnings and precautions|Warnings and Precautions]]''' | ||
'''| [[Cefazolin sodium adverse reactions|Adverse Reactions]]''' | '''| [[Cefazolin sodium adverse reactions|Adverse Reactions]]''' | ||
'''| [[Cefazolin sodium dosage and administration|Dosage and Administration]]''' | '''| [[Cefazolin sodium dosage and administration|Dosage and Administration]]''' | ||
'''| [[Cefazolin sodium compatibility reconstitution and stability|Compatibility, Reconstitution, and Stability]]''' | '''| [[Cefazolin sodium compatibility reconstitution and stability|Compatibility, Reconstitution, and Stability]]''' | ||
'''| [[Cefazolin sodium how supplied|How Supplied]]''' | '''| [[Cefazolin sodium how supplied|How Supplied]]''' | ||
'''| [[Cefazolin sodium labels and packages|Labels and Packages]]''' | '''| [[Cefazolin sodium labels and packages|Labels and Packages]]''' |
Revision as of 00:25, 6 January 2014
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sheng Shi, M.D. [2]
Overview
Cefazolin (INN), also known as cefazoline or cephazolin, is a first generation cephalosporin antibiotic.
The drug is usually administrated either by intramuscular injection (injection into a large muscle) or intravenous infusion (intravenous fluid into a vein).
Category
Cephalosporin, First-Generation
US Brand Names
ANCEF®
FDA Package Insert
Description | Clinical Pharmacology | Microbiology | Indications and Usage | Contraindications | Warnings and Precautions | Adverse Reactions | Dosage and Administration | Compatibility, Reconstitution, and Stability | How Supplied | Labels and Packages
Mechanism of Action
Cefazolin sodium belongs to the first-genaration Cephalosporins.Cephalosporins are bactericidal and have the same mode of action as other beta-lactam antibiotics (such as penicillins). Cephalosporins disrupt the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The final transpeptidation step in the synthesis of the peptidoglycan is facilitated by transpeptidases known as penicillins binding proteins (PBPs)