Cefazolin sodium: Difference between revisions
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==US Brand Names== | ==US Brand Names== | ||
ANCEF<sup>®</sup> | CEFAZOLIN<sup>®</sup>, ANCEF<sup>®</sup> | ||
==FDA Package Insert== | ==FDA Package Insert== | ||
Revision as of 00:29, 6 January 2014
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sheng Shi, M.D. [2]
Synonyms and keywords: Cefazoline; Cephazolin
Overview
Cefazolin is a first generation cephalosporin antibiotic. The drug is usually administrated either by intramuscular injection (injection into a large muscle) or intravenous infusion (intravenous fluid into a vein).
Category
Cephalosporin, First-Generation
US Brand Names
CEFAZOLIN®, ANCEF®
FDA Package Insert
Description | Clinical Pharmacology | Microbiology | Indications and Usage | Contraindications | Warnings and Precautions | Adverse Reactions | Dosage and Administration | Compatibility, Reconstitution, and Stability | How Supplied | Labels and Packages
Mechanism of Action
Cefazolin sodium belongs to the first-genaration Cephalosporins.Cephalosporins are bactericidal and have the same mode of action as other beta-lactam antibiotics (such as penicillins). Cephalosporins disrupt the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The final transpeptidation step in the synthesis of the peptidoglycan is facilitated by transpeptidases known as penicillin-binding proteins (PBPs).