Colistimethate sodium dosage and administration: Difference between revisions
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In obese individuals, dosage should be based on ideal body weight. | In obese individuals, dosage should be based on ideal body weight. | ||
The daily dose and frequency should be reduced for the patients with [[Renal failure|renal impairment]]. Suggested modifications of dosage schedule for patients with renal impairment are presented in Table 1. | The daily dose and frequency should be reduced for the patients with [[Renal failure|renal impairment]]. Suggested modifications of dosage schedule for patients with renal impairment are presented in Table 1.<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = COLY-MYCIN M (COLISTIMETHATE) INJECTION [JHP PHARMACEUTICALS LLC] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=6d6e13e2-dc33-4b7b-84d0-66146a57c552 | publisher = | date = | accessdate}}</ref> | ||
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==References== | |||
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{{FDA}} | |||
[[Category:Antibiotics]] | |||
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Revision as of 02:06, 7 January 2014
Dosage and Administration
Important: Coly-Mycin M Parenteral is supplied in vials containing colistimethate sodium equivalent to 150 mg colistin base activity per vial.
Reconstitution for Intravenous or Intramuscular Administration
The 150 mg vial should be reconstituted with 2 mL Sterile Water for Injection, USP. The reconstituted solution provides colistimethate sodium at a concentration equivalent to 75 mg/mL colistin base activity.
During reconstitution swirl gently to avoid frothing.
Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. If these conditions are observed, the product should not be used.
Dosage
Adults and Pediatric Patients—Intravenous or Intramuscular Administration
The dose of Coly-Mycin M Parenteral should be 2.5 to 5 mg/kg per day of colistin base in 2 to 4 divided doses for patients with normal renal function, depending on the severity of the infection.
In obese individuals, dosage should be based on ideal body weight.
The daily dose and frequency should be reduced for the patients with renal impairment. Suggested modifications of dosage schedule for patients with renal impairment are presented in Table 1.[1]
References
- ↑ "COLY-MYCIN M (COLISTIMETHATE) INJECTION [JHP PHARMACEUTICALS LLC]". Text " accessdate" ignored (help)
Adapted from the FDA Package Insert.