Halofantrine: Difference between revisions

Revision as of 02:44, 7 January 2014

Halofantrine
HALFAN^® FDA Package Insert
Description
Clinical Pharmacology
Microbiology
Indications and Usage
Contraindications
Warnings and Precautions
Adverse Reactions
Drug Interactions
Overdosage
Dosage and Administration
How Supplied

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Halofantrine is a drug used to treat malaria. It belongs to the phenanthrene class of compounds that includes quinine and lumefantrine. It is never used to prevent malaria. Its mode of action is unknown.

US Brand Names

HALFAN^® (DISCONTINUED)

FDA Package Insert

Mechanism of Action

The mechanism of action of halofantrine is unknown.

References

@@ Line 8: / Line 8: @@
 ==Category==
+Antiparasitic
 ==US Brand Names==
-HALFAN
+HALFAN<sup>®</sup> (''DISCONTINUED'')
 ==FDA Package Insert==
-'''  [[XXXXX description|Description]]'''
+'''  [[Halofantrine description|Description]]'''
-'''| [[XXXXX clinical pharmacology|Clinical Pharmacology]]'''
+'''| [[Halofantrine clinical pharmacology|Clinical Pharmacology]]'''
-'''| [[XXXXX microbiology|Microbiology]]'''
+'''| [[Halofantrine microbiology|Microbiology]]'''
-'''| [[XXXXX indications and usage|Indications and Usage]]'''
+'''| [[Halofantrine indications and usage|Indications and Usage]]'''
-'''| [[XXXXX contraindications|Contraindications]]'''
+'''| [[Halofantrine contraindications|Contraindications]]'''
-'''| [[XXXXX warnings and precautions|Warnings and Precautions]]'''
+'''| [[Halofantrine warnings and precautions|Warnings and Precautions]]'''
-'''| [[XXXXX adverse reactions|Adverse Reactions]]'''
+'''| [[Halofantrine adverse reactions|Adverse Reactions]]'''
-'''| [[XXXXX drug interactions|Drug Interactions]]'''
+'''| [[Halofantrine drug interactions|Drug Interactions]]'''
-'''| [[XXXXX overdosage|Overdosage]]'''
+'''| [[Halofantrine overdosage|Overdosage]]'''
-'''| [[XXXXX clinical studies|Clinical Studies]]'''
+'''| [[Halofantrine clinical studies|Clinical Studies]]'''
-'''| [[XXXXX dosage and administration|Dosage and Administration]]'''
+'''| [[Halofantrine dosage and administration|Dosage and Administration]]'''
-'''| [[XXXXX how supplied|How Supplied]]'''
+'''| [[Halofantrine how supplied|How Supplied]]'''
-'''| [[XXXXX labels and packages|Labels and Packages]]'''
+'''| [[Halofantrine labels and packages|Labels and Packages]]'''
 ==Mechanism of Action==
-The mechanism of action of halofantrine is unknown.  The absorption of halofantrine is erratic, but is increased when taken with fatty food.  Because of fears of toxicity due to increased halofantrine blood levels, halofantrine should be taken on an empty stomach.
-Plasma levels peak at 16 hours and the half-life of the drug is about 4 days.
-==Adverse reactions==
-Halofantrine can cause abdominal pain, [[diarrhoea]], vomiting, rash, headache, itching and elevated liver enzymes.  The most dangerous side effect is [[cardiac arrhythmia]]s: halofantrine causes significant [[QT prolongation]], and this effect is seen even at standard doses.  The drug should therefore not be given to patients with cardiac conduction defects and should not be combined with [[mefloquine]].
-==Pharmacology==
+The mechanism of action of halofantrine is unknown.
 ==References==