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| {{drugbox
| | __NOTOC__ |
| | IUPAC_name = 1-(2-ethylsulfonylethyl)-2-methyl-5-nitro-imidazole
| | {{XXXXX}} |
| | image = Tinidazole.png
| | {{CMG}} |
| | CAS_number = 19387-91-8
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| | ATC_prefix = J01
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| | ATC_suffix = XD02
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| | ATC_supplemental = {{ATC|P01|AB02}}
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| | PubChem = 5479
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| | DrugBank = APRD01260
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| | C=8 | H=13 | N=3 | O=4 | S=1
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| | molecular_weight = 247.273 g/mol
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| | bioavailability =
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| | metabolism =
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| | elimination_half-life =
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| '''Tinidazole''' is an anti-parasitic [[Medication|drug]] used against [[protozoan]] infections. It is widely known throughout Europe and the developing world as treatment for a variety of amoebic and parasitic infections. It is chemically similar to [[Metronidazole]] — a drug with some unpleasant side effects that is used in the United States as first-line therapy for amoebae. Tinidazole has similar side effects but has a shorter treatment course.
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| Tinidazole is FDA approved for the treatment of [[trichomoniasis]], [[giardiasis]] and [[amebiasis]]. A large body of clinical data exists to support its use as a treatment for amoebae, giardia and vaginal trichomona, just like metronidazole. Tinidazole may be a therapeutic alternative in the setting of metronidazole tolerance.
| | ==Overview== |
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| Tinidazole may also be used to treat or prevent a variety of bacterial infections, including [[Helicobacter pylori]].
| | ==Category== |
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| Tinidazole is marketed by [[Mission Pharmacal]] under the brand name '''Tindamax®''', and by [[Pfizer]] under the name '''Fasigyn®'''.
| | ==US Brand Names== |
| | TINDAMAX<sup>®</sup> |
| | ==FDA Package Insert== |
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| == Side Effects ==
| | ''' [[XXXXX description|Description]]''' |
| The most common side effects reported with tinidazole are [[upset stomach]], [[bitter taste]], and [[itchiness]]. Other side effects which occur are [[headache]], [[fatigue (physical)|fatigue]], and [[dizziness]]. Anecdotally, people who have taken both Flagyl and tinidazole report toxicity is much the same except the side effects don't last as long. Note: drinking alcohol while taking tinidazole will make you violently ill.
| | '''| [[XXXXX clinical pharmacology|Clinical Pharmacology]]''' |
| | '''| [[XXXXX microbiology|Microbiology]]''' |
| | '''| [[XXXXX indications and usage|Indications and Usage]]''' |
| | '''| [[XXXXX contraindications|Contraindications]]''' |
| | '''| [[XXXXX warnings and precautions|Warnings and Precautions]]''' |
| | '''| [[XXXXX adverse reactions|Adverse Reactions]]''' |
| | '''| [[XXXXX drug interactions|Drug Interactions]]''' |
| | '''| [[XXXXX overdosage|Overdosage]]''' |
| | '''| [[XXXXX clinical studies|Clinical Studies]]''' |
| | '''| [[XXXXX dosage and administration|Dosage and Administration]]''' |
| | '''| [[XXXXX how supplied|How Supplied]]''' |
| | '''| [[XXXXX labels and packages|Labels and Packages]]''' |
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| == Half Life == | | ==Mechanism of Action== |
| Elimination half-life is 13.2 ± 1.4 hours. Plasma half-life is 12 to 14 hours.
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| == External links == | | ==References== |
| * [http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a604036.html MedlinePlus Drug Information: Tinidazole]
| | {{Reflist|2}} |
| * [http://www.tindamax.com/ Tindamax]
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| * [http://www.fda.gov/cder/foi/label/2004/21618_tindamax_lbl.pdf Tindamax Labeling] (PDF)
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| * [http://www.meds-help.com/tinidazole/ Tinidazole] (patient information)
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| * [http://redpoll.pharmacy.ualberta.ca/drugbank/cgi-bin/getCard.cgi?CARD=APRD01260.txt Drug Bank Facts on Tinidazole]
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| | | [[Category:Antibiotics]] |
| {{Other antibacterials}}
| | [[Category:Wikinfect]] |
| {{Agents against amoebiasis and other protozoal diseases}}
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| [[Category:Antiprotozoal agents]] | |
| [[Category:Imidazoles]] | |
| {{WikiDoc Sources}}
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