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| <small>'''''Synonyms / Brand Names:''''' CLA, Clarithromycine, Clathromycin, Biaxin, Biaxin XL, Klacid, Klaricid, Macladin, Naxy, Veclam, Zeclar </small>
| | __NOTOC__ |
| | {{Clarithromycin}} |
| | {{CMG}}; {{AE}} {{chetan}} |
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| {{CMG}}
| | ==Overview== |
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| ==Dosing and Administration== | | ==Category== |
| BIAXIN Filmtab (clarithromycin tablets, USP) and BIAXIN Granules (clarithromycin for oral suspension, USP) may be given with or without food. BIAXIN XL Filmtab (clarithromycin extended-release tablets) should be taken with food. BIAXIN XL tablets should be swallowed whole and not chewed, broken or crushed.
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| '''Adult dosage guidelines'''
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| <br>
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| For pharyngitis/tonsillitis due to S. pyogenes:
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| *250 mg (q12h) of BIAXIN tablets should be given for a duration of 10 days.
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| For acute maxillary sinusitis due to H. influenzae, M. catarrhalis, and/or S. pneumonia:
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| *500 mg (q12h) of BIAXIN tablets should be given for a duration of 14 days or
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| *2 x 500 mg (q24h) of BIAXIN XL tablets should be given for a duration of 14 days.
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| For acute exacerbation of chronic bronchitis due to H. influenzae, M catarrhalis, and/or S. pneumoniae:
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| *500 mg (q12h) of BIAXIN tablets should be given for a duration of 7-14 days or
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| *2 x 500 mg (q24h) of BIAXIN XL tablets should be given for a duration of 7 days.
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| For acute exacerbation of chronic bronchitis due to H. parainfluenzae:
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| *500 mg (q12h) of BIAXIN tablets should be given for a duration of 7 days or
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| *2 x 500 mg (q24h) of BIAXIN XL tablets should be given for a duration of 7 days.
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| For community-acquired pneumonia due to H. influenzae:
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| *250 mg (q12h) of BIAXIN tablets should be given for a duration of 7 days or
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| *2 x 500 mg (q24h) of BIAXIN XL tablets should be given for a duration of 7 days.
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| For community-acquired pneumonia due to H. parainfluenzae and/or M. catarrhalis:
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| *2 x 500 mg (q24h) of BIAXIN XL tablets should be given for a duration of 7 days.
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| For community-acquired pneumonia due to S. pneumoniae, C. pneumoniae, and/or M. pneumoniae:
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| *250 mg (q12h) of BIAXIN tablets should be given for a duration of 7-14 days or
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| *2 x 500 mg (q24h) of BIAXIN XL tablets should be given for a duration of 7 days.
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| For uncomplicated skin and skin structure due to S. aureus and/or S.pyogenes:
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| *250 mg (q12h) of BIAXIN tablets should be given for a duration of 7 days.
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| For further dosage and administration instructions see [[{{PAGENAME}} instructions for administration|Instructions for Administration]].
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| <br>
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| ----
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| <br>
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| <font size="4">
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| [[{{PAGENAME}}#FDA Package Insert Resources|FDA Package Insert Resources]]
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| <br></font size><small>Indications, Contraindications, Side Effects, Drug Interactions, etc.</small><font size="4"><br>
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| <br>
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| [http://www.pace-med-apps.com/gfrcalc.htm Calculate Creatine Clearance]
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| <br></font size><small>On line calculator of your patients Cr Cl by a variety of formulas.</small><font size="4"><br>
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| <br>
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| [http://home.earthlink.net/~sensei11/convert.htm Convert pounds to Kilograms]
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| <br></font size><small>On line calculator of your patients weight in pounds to Kg for dosing estimates.</small><font size="4"><br>
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| <br> [[{{PAGENAME}}#Publication Resources|Publication Resources]]
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| <br></font size><small>Recent articles, WikiDoc State of the Art Review, Textbook Information</small><font size="4"><br>
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| <br>
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| [[{{PAGENAME}}#Trial Resources|Trial Resources]]
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| <br></font size><small>Ongoing Trials, Trial Results</small><font size="4"><br>
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| [[{{PAGENAME}}#Guidelines & Evidence Based Medicine Resources|Guidelines & Evidence Based Medicine Resources]]
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| <br></font size><small>US National Guidelines, Cochrane Collaboration, etc.</small><font size="4"><br>
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| <br>
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| [[{{PAGENAME}}#Media Resources|Media Resources]]
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| <br></font size><small>Slides, Video, Images, MP3, Podcasts, etc.</small><font size="4"><br><br>
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| [[{{PAGENAME}}#Patient Resources|Patient Resources]]
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| <br></font size><small>Discussion Groups, Handouts, Blogs, News, etc.</small><font size="4"><br>
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| [[{{PAGENAME}}#International Resources|International Resources]]
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| <br></font size><small>en Español</small><font size="4"><br>
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| ----
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| ==FDA Package Insert Resources== | | ==US Brand Names== |
| [[{{PAGENAME}} indications|Indications]]
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| [[{{PAGENAME}} contraindications|Contraindications]]
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| [[{{PAGENAME}} side effects|Side Effects]]
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| [[{{PAGENAME}} drug interactions|Drug Interactions]]
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| [[{{PAGENAME}} precautions|Precautions]]
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| [[{{PAGENAME}} overdose|Overdose]]
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| [[{{PAGENAME}} instructions for administration|Instructions for Administration]]
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| [[{{PAGENAME}} how supplied|How Supplied]]
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| [[{{PAGENAME}} pharmacokinetics and molecular data|Pharmacokinetics and Molecular Data]]
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| [http://www.fda.gov/cder/foi/label/2007/050662s040,050698s022,050775s011lbl.pdf FDA label]
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| [http://google2.fda.gov/search?q={{urlencode:{{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}}}&x=0&y=0&client=FDA&site=FDA&lr=&proxystylesheet=FDA&output=xml_no_dtd&getfields=* FDA on {{PAGENAME}}]
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| <br>
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| </font size><small>[[{{PAGENAME}}#Dosing and Administration|Return to top]]</small><font size="4">
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| ==Publication Resources== | | ==FDA Package Insert== |
| [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&db=pubmed&term={{urlencode:{{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}}} Most Recent Articles on {{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}]
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| [http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=search&db=pubmed&term={{urlencode:{{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}}}%20AND%20systematic%5Bsb%5D Review Articles on {{PAGENAME}}]
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| [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&db=pubmed&term={{urlencode:{{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}}}+AND+%28%28N+Engl+J+Med%5Bta%5D%29+OR+%28Lancet%5Bta%5D%29+OR+%28BMJ%5Bta%5D%29%29 Articles on {{PAGENAME}} in N Eng J Med, Lancet, BMJ]
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| [[WikiDoc state of the art review on {{PAGENAME}}|WikiDoc State of the Art Review]]
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| [http://books.google.com/books?ie=UTF-8&oe=utf-8&q={{urlencode:{{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}}}&qt_s=Search&sa=N&tab=gp Textbook Information on {{PAGENAME}}]
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| </font size><small>[[{{PAGENAME}}#Dosing and Administration|Return to top]]</small><font size="4">
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| ==Trial Resources==
| | ''' [[Clarithromycin description|Description]]''' |
| [http://clinicaltrials.gov/search/open/condition={{urlencode:{{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}}} Ongoing Trials with {{PAGENAME}} at Clinical Trials.gov] | | '''| [[Clarithromycin clinical pharmacology|Clinical Pharmacology]]''' |
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| | '''| [[Clarithromycin microbiology|Microbiology]]''' |
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| | '''| [[Clarithromycin indications and usage|Indications and Usage]]''' |
| [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&db=pubmed&term={{urlencode:{{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}}}+AND+%28randomized+controlled+trial%5BPublication+Type%5D+OR+%28randomized%5BTitle%2FAbstract%5D+AND+controlled%5BTitle%2FAbstract%5D+AND+trial%5BTitle%2FAbstract%5D%29%29 Trial Results with {{PAGENAME}}] | | '''| [[Clarithromycin contraindications|Contraindications]]''' |
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| | '''| [[Clarithromycin warnings and precautions|Warnings and Precautions]]''' |
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| | '''| [[Clarithromycin adverse reactions|Adverse Reactions]]''' |
| </font size><small>[[{{PAGENAME}}#Dosing and Administration|Return to top]]</small><font size="4">
| | '''| [[Clarithromycin drug interactions|Drug Interactions]]''' |
| <br>
| | '''| [[Clarithromycin overdosage|Overdosage]]''' |
| <br>
| | '''| [[Clarithromycin clinical studies|Clinical Studies]]''' |
| | '''| [[Clarithromycin dosage and administration|Dosage and Administration]]''' |
| | '''| [[Clarithromycin how supplied|How Supplied]]''' |
| | '''| [[Clarithromycin labels and packages|Labels and Packages]]''' |
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| ==Guidelines & Evidence Based Medicine Resources== | | ==Mechanism of Action== |
| [http://www.guideline.gov/search/searchresults.aspx?Type=3&txtSearch={{urlencode:{{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}}}&num=20 US National Guidelines Clearinghouse on {{PAGENAME}}]
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| [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&db=pubmed&term={{urlencode:({{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}) AND (Cochrane Database Syst Rev[ta])}} Cochrane Collaboration on {{PAGENAME}}]
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| [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&db=pubmed&term={{urlencode:({{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}) AND (Cost effectiveness)}} Cost Effectiveness of {{PAGENAME}}]
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| </font size><small>[[{{PAGENAME}}#Dosing and Administration|Return to top]]</small><font size="4">
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| ==Media Resources==
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| [http://www.google.com/search?q={{urlencode:{{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}}}+ppt&ie=utf-8&oe=utf-8&aq=t&rls=org.mozilla:en-US:official&client=firefox-a Powerpoint Slides on {{PAGENAME}}]
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| [http://images.google.com/images?q={{urlencode:{{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}}}&ie=UTF-8&oe=utf-8&rls=org.mozilla:en-US:official&client=firefox-a&um=1&sa=N&tab=wi Images of {{PAGENAME}}]
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| [http://www.google.com/search?hl=en&client=firefox-a&rls=org.mozilla%3Aen-US%3Aofficial&hs=hPo&q={{urlencode:{{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}}}+podcasts+OR+MP3&btnG=Search Podcasts & MP3s on {{PAGENAME}}]
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| [http://video.google.com/videosearch?q={{urlencode:{{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}}}&ie=UTF-8&oe=utf-8&rls=org.mozilla:en-US:official&um=1&sa=N&tab=fv# Videos on {{PAGENAME}}]
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| </font size><small>[[{{PAGENAME}}#Dosing and Administration|Return to top]]</small><font size="4">
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| ==Patient Resources== | | ==References== |
| [[{{PAGENAME}} (patient information)|Patient Information from National Library of Medicine]]
| | {{Reflist|2}} |
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| [http://www.google.com/search?hl=en&q={{urlencode:{{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}}}+more:for_patients&cx=disease_for_patients&sa=N&oi=cooptsr&resnum=0&ct=col3&cd=1 Patient Resources on {{PAGENAME}}]
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| [http://groups.google.com/groups/search?ie=UTF-8&oe=utf-8&q={{urlencode:{{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}}}&qt_s=Search Discussion Groups on {{PAGENAME}}]
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| [http://www.google.com/search?hl=en&client=firefox-a&rls=org.mozilla:en-US:official&q={{urlencode:{{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}}}+more:patient_handouts&cx=disease_for_health_professionals&sa=N&oi=coopctx&resnum=0&ct=col1&cd=3 Patient Handouts on {{PAGENAME}}]
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| [http://blogsearch.google.com/blogsearch?q={{urlencode:{{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}}}&ie=UTF-8&oe=utf-8&rls=org.mozilla:en-US:official&client=firefox-a&um=1&sa=N&tab=wb Blogs on {{PAGENAME}}]
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| [http://news.google.com/news?q={{urlencode:{{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}}}&ie=UTF-8&oe=utf-8&rls=org.mozilla:en-US:official&client=firefox-a&um=1&sa=N&tab=wn {{PAGENAME}} in the News]
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| [http://finance.google.com/finance?ie=UTF-8&oe=utf-8&q={{urlencode:{{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}}}&qt_s=Search&sa=N&tab=te {{PAGENAME}} in the Marketplace]
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| ==International Resources==
| | [[Category:Antibiotics]] |
| [http://www.google.com/search?q={{urlencode:{{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}}}+en+espanol&ie=utf-8&oe=utf-8&aq=t&rls=org.mozilla:en-US:official&client=firefox-a {{PAGENAME}} en Español] | | [[Category:Wikinfect]] |
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| ----
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| {{FDA}}
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| [[Category:Drugs]] | |