Renal cell carcinoma history and symptoms: Difference between revisions
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==Overview== | ==Overview== | ||
==Symptoms | ==Symptoms== | ||
Patients with renal cell carcinoma typically present at 60-70 years of age. The most common diagnosis of renal cell carcinoma is based on the incidental finding; whereby most patients are asymptomatic. | Patients with renal cell carcinoma typically present at 60-70 years of age. The most common diagnosis of renal cell carcinoma is based on the incidental finding; whereby most patients are asymptomatic. | ||
Symptoms are often classified as local and systemic | Symptoms are often classified as local and systemic. | ||
===Local Symptoms | ===Local Symptoms=== | ||
The presence of local signs is considered a poor prognostic marker | The presence of local signs is considered a poor prognostic marker<ref name="pmid19269025">{{cite journal| author=Rini BI, Campbell SC, Escudier B| title=Renal cell carcinoma. | journal=Lancet | year= 2009 | volume= 373 | issue= 9669 | pages= 1119-32 | pmid=19269025 | doi=10.1016/S0140-6736(09)60229-4 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19269025 }} </ref>. Common local symptoms are listed below<ref name="pmid19269025">{{cite journal| author=Rini BI, Campbell SC, Escudier B| title=Renal cell carcinoma. | journal=Lancet | year= 2009 | volume= 373 | issue= 9669 | pages= 1119-32 | pmid=19269025 | doi=10.1016/S0140-6736(09)60229-4 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19269025 }} </ref>: | ||
*Hematuria | *Hematuria | ||
*Flank pain | *Flank pain | ||
*Palpable abdominal mass | *Palpable abdominal mass | ||
===Systemic Symptoms | ===Systemic Symptoms=== | ||
The presence of systemic symptoms is mostly due to the presence of a paraneoplastic syndrome, mostly due to the presence of parathyroid-related protein (PTHrp) or a metastasis. | The presence of systemic symptoms is mostly due to the presence of a paraneoplastic syndrome, mostly due to the presence of parathyroid-related protein (PTHrp) or a metastasis.<ref name="pmid19269025">{{cite journal| author=Rini BI, Campbell SC, Escudier B| title=Renal cell carcinoma. | journal=Lancet | year= 2009 | volume= 373 | issue= 9669 | pages= 1119-32 | pmid=19269025 | doi=10.1016/S0140-6736(09)60229-4 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19269025 }} </ref> Common systemic symptoms are listed below<ref name="pmid19269025">{{cite journal| author=Rini BI, Campbell SC, Escudier B| title=Renal cell carcinoma. | journal=Lancet | year= 2009 | volume= 373 | issue= 9669 | pages= 1119-32 | pmid=19269025 | doi=10.1016/S0140-6736(09)60229-4 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19269025 }} </ref>: | ||
*Hypertension (renin secretion) | *Hypertension (renin secretion) | ||
*Hypercalcemia (PTHrp secretion) | *Hypercalcemia (PTHrp secretion) |
Revision as of 17:37, 11 January 2014
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Overview
Symptoms
Patients with renal cell carcinoma typically present at 60-70 years of age. The most common diagnosis of renal cell carcinoma is based on the incidental finding; whereby most patients are asymptomatic. Symptoms are often classified as local and systemic.
Local Symptoms
The presence of local signs is considered a poor prognostic marker[1]. Common local symptoms are listed below[1]:
- Hematuria
- Flank pain
- Palpable abdominal mass
Systemic Symptoms
The presence of systemic symptoms is mostly due to the presence of a paraneoplastic syndrome, mostly due to the presence of parathyroid-related protein (PTHrp) or a metastasis.[1] Common systemic symptoms are listed below[1]:
- Hypertension (renin secretion)
- Hypercalcemia (PTHrp secretion)
- Flushing (Erythroprotein secretion)
- Fever
- Fatigue
- Weight loss
- Anorexia
- Muscle atrophy
References
- ↑ 1.0 1.1 1.2 1.3 Rini BI, Campbell SC, Escudier B (2009). "Renal cell carcinoma". Lancet. 373 (9669): 1119–32. doi:10.1016/S0140-6736(09)60229-4. PMID 19269025.