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Streptococcus pneumoniae

Penicillin MIC ≤0.06 μg/mL Preferred Regimen ▸ Penicillin G' OR ▸ Ampicillin Alternative Regimen ▸ Cefotaxime OR ▸ Ceftriaxone OR ▸ Chloramphenicol

Penicillin MIC ≥0.12 μg/mL Cefotaxime or Ceftriaxone MIC† <1.0 μg/mL Preferred Regimen ▸ Cefotaxime OR ▸ Ceftriaxone Alternative Regimen ▸ Cefepime OR ▸ Meropenem Cefotaxime or Ceftriaxone MIC† >1.0 μg/mL Preferred Regimen ▸ Vancomycin AND ▸ Cefotaxime OR ▸ Ceftriaxone Alternative Regimen ▸ Vancomycin AND ▸ Moxifloxacin

Neisseria meningitidis

Neisseria meningitidis Penicillin MIC <0·1 μg/mL Preferred Regimen ▸ Penicillin G OR ▸ Ampicillin Alternative Regimen ▸ Cefotaxime OR ▸ Ceftriaxone OR ▸ Chloramphenicol

Neisseria meningitidis Penicillin MIC ≥0·1 μg/mL Preferred Regimen ▸ Cefotaxime OR ▸ Ceftriaxone Alternative Regimen ▸ Cefepime OR ▸ Chloramphenicol OR ▸ Fluoroquinolone OR ▸ Meropenem

Listeria Monocytogenes and Streptococcus agalactiae

Listeria Monocytogenes Preferred Regimen ▸ Ampicillin OR ▸ Penicillin G Alternative Regimen ▸ Trimethoprim-sulfamethoxazole

Streptococcus agalactiae Preferred Regimen ▸ Ampicillin OR ▸ Penicillin G Alternative Regimen ▸ Cefotaxime OR ▸ Ceftriaxone OR ▸ Vancomycin

Haemophilus influenzae

Haemophilus influenzae β-lactamase negative Preferred Regimen ▸ Ampicillin Alternative Regimen ▸ Cefotaxime OR ▸ Ceftriaxone OR ▸ Cefepime OR ▸ Chloramphenicol OR ▸ Aztreonam OR ▸ Fluoroquinolone

Haemophilus influenzae β-lactamase positive Preferred Regimen ▸ Cefotaxime OR ▸ Ceftriaxone Alternative Regimen ▸ Cefepime OR ▸ Chloramphenicol, OR ▸ Aztreonam OR ▸ Fluoroquinolone

Haemophilus influenzae β-lactamase negative, ampicillin resistant Preferred Regimen ▸ Meropenem Alternative Regimen ▸ Fluoroquinolone

Staphylococcus aureus

Staphylococcus aureus Meticillin sensitive Preferred Regimen ▸ Nafcillin OR ▸ Oxacillin Alternative Regimen ▸ Vancomycin OR ▸ linezolid OR ▸ Daptomycin

Staphylococcus aureus Meticillin resistant Preferred Regimen ▸ Vancomycin Alternative Regimen ▸ Trimethoprim-sulfamethoxazole OR ▸ linezolid OR ▸ Daptomycin

Staphylococcus epidermidis and Acinetobacter baumannii

Staphylococcus epidermidis Preferred Regimen ▸ Vancomycin Alternative Regimen ▸ Linezolid Acinetobacter baumannii Preferred Regimen ▸ Meropenem Alternative Regimen ▸ Colistin OR ▸ Polymyxin B Enterobacteriaceae and Pseudomonas aeruginosa Enterobacteriaceae Preferred Regimen ▸ Cefotaxime OR ▸ Ceftriaxone Alternative Regimen ▸ Aztreonam OR ▸ Fluoroquinolone OR ▸ Trimethoprim-sulfamethoxazole OR ▸ Meropenem OR ▸ Ampicillin Pseudomonas aeruginosa Preferred Regimen ▸ Ceftazidime OR ▸ Cefepime Alternative Regimen ▸ Aztreonam OR ▸ Meropenem OR ▸ Ciprofloxacin