Sandbox fungal meningitis: Difference between revisions

	Meningitis Main Page
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Revision as of 18:32, 20 January 2014

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ;Sheng Shi, M.D. [2]

Blastomyces
Preferred Regimen
▸ Liposomal amphotericin B 5 mg/kg/day IV for 4–6 weeks
Followed By
▸ Fluconazole 800 mg/day PO OR ▸ Itraconazole 200 mg PO bid or tid OR ▸ Voriconazole 200–400 mg IV q12h

Histoplasma
Preferred Regimen
▸ Liposomal ampho B 5 mg/kg/d, for a total of 175 mg/kg over 4-6 wk
Followed By
▸ *Itraconazole 200 mg/day PO bid or tid for at least 12 month*

Coccidioides
Preferred Regimen
▸ FLuconazole 400 mg/day PO OR ▸ Itraconazole 400–600 mg/day PO

Cryptococcus, HIV/AIDS
Induction Phrase(for 2 wks)
▸ Amphotericin B deoxycholate 0.7 mg/kg/day IV
PLUS
▸ 5-Fluorocytosine 100 mg/kg/day PO
Consolidation phase(for 8 wks)
▸ Fluconazole 400 mg/day PO OR ▸ Itraconazole 400 mg/day PO
Maintenance phase
▸ Fluconazole 200 mg/day PO

Cryptococcus, Immunocompetent
Induction Phrase(for 2 wks)
▸ Amphotericin B 0.7-1 mg/kg/day IV OR ▸ *Liposomal amphotericin B 5 mg/kg/day PO*
PLUS
▸ 5-Fluorocytosine 25 mg/kg PO q6h
Consolidation phase(for 8 wks)
▸ Fluconazole 400 mg/day PO qd
Maintenance phase(for 12 mo)
▸ Fluconazole 200 mg PO qd

Herpes simplex Meningitis
Preferred Regimen
▸ Aciclovir IV OR ▸ ValaciclovirPO

↑ Galgiani JN, Ampel NM, Blair JE, Catanzaro A, Johnson RH, Stevens DA et al. (2005) Coccidioidomycosis. Clin Infect Dis 41 (9):1217-23. DOI:10.1086/496991 PMID: 16206093
↑ Antinori S (2013) New Insights into HIV/AIDS-Associated Cryptococcosis. ISRN AIDS 2013 ():471363.http://dx.doi.org/10.1155/2013/471363 DOI:10.1155/2013/471363] PMID: 24052889
↑ Jackson A, van der Horst C (2012) New insights in the prevention, diagnosis, and treatment of cryptococcal meningitis. Curr HIV/AIDS Rep 9 (3):267-77. DOI:10.1007/s11904-012-0127-7 PMID: 22763808

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-===Coccidioides===
+===Coccidioides<ref name="pmid16206093">Galgiani JN, Ampel NM, Blair JE, Catanzaro A, Johnson RH, Stevens DA et al. (2005) [http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=16206093 Coccidioidomycosis.] ''Clin Infect Dis'' 41 (9):1217-23. [http://dx.doi.org/10.1086/496991 DOI:10.1086/496991] PMID: [http://pubmed.gov/16206093 16206093]</ref>===
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+==Viral Meningitis==
+{|
+|-
+| valign=top |
+{| style="margin: 0 0 0em 0em; border: 1px solid #696969; float: left; width:39em" cellpadding="0" cellspacing="0";
+! style="padding: 0 5px; font-size: 100%; background: #F8F8FF" align=center | ''{{fontcolor|#6C7B8B|[[Herpes simplex Meningitis]]}}''
+|-
+! style="padding: 0 5px; font-size: 80%; background: #F5F5F5" align=left | ''Preferred Regimen''
+|-
+| style="font-size: 80%; padding: 0 5px; background: #DCDCDC" align=left | ▸ '''''[[Aciclovir]]''''' IV  <BR>''OR''<BR>▸ '''''[[Valaciclovir]]'''''PO
+|-
+|}
+|}