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{{drugbox
{{DrugProjectFormSinglePage
| IUPAC_name = Human urokinase
|genericName=generic name
| image = 1VJA.png
|aOrAn=a
| Caption = The protease domain from urokinase in complex with and [[inhibitor]]
|drugClass=Adrenergic receptor agonist
| CAS_number = 9039-53-6
|indication=a list of indications, separated by commas.
| ATC_prefix = B01
|hasBlackBoxWarning=Yes
| ATC_suffix = AD04
|adverseReactions=a list of adverse reactions, separated by commas.
| ATC_supplemental =  
|blackBoxWarningTitle=Warning Title
| PubChem =  
|blackBoxWarningBody=<i><span style="color:#FF0000;">Condition Name:</span></i> (Content)
| DrugBank = BTD00030
|fdaLIADAdult======Condition 1=====
| C=1376 | H=2145 | N=383 | O=406 | S=18
 
| molecular_weight = 31126.5 g/mol
* Dosing Information
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| protein_bound =  
:* (Dosage)
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| elimination_half-life =  
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| legal_status =  
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:* (Dosage)
{{protein
|offLabelAdultGuideSupport======Condition 1=====
| Name = plasminogen activator, urokinase
 
| caption =  
* Developed by: (Organisation)
| image =  
 
| width =  
* Class of Recommendation: (Class) (Link)
| HGNCid = 9052
 
| Symbol = PLAU
* Strength of Evidence: (Category A/B/C) (Link)
| AltSymbols =  
 
| EntrezGene = 5328
* Dosing Information/Recommendation
| OMIM = 191840
 
| RefSeq = NM_002658
:* (Dosage)
| UniProt = P00749
 
| PDB =  
=====Condition 2=====
| ECnumber = 3.4.21.31
 
| Chromosome = 10
* Developed by: (Organisation)
| Arm = q
 
| Band = 24
* Class of Recommendation: (Class) (Link)
| LocusSupplementaryData =  
 
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* Strength of Evidence: (Category A/B/C) (Link)
{{SI}}
 
{{CMG}}
* Dosing Information/Recommendation
 
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* Dosing Information
 
:* (Dosage)
 
=====Condition 2=====
 
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=====Condition 2=====
 
* Developed by: (Organisation)
 
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* Strength of Evidence: (Category A/B/C) (Link)
 
* Dosing Information/Recommendation
 
:* (Dosage)
|offLabelPedNoGuideSupport======Condition 1=====
 
* Dosing Information
 
:* (Dosage)
 
=====Condition 2=====
 
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:* (Dosage)
 
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* Dosing Information
 
:* (Dosage)
|contraindications=* Condition 1
* Condition 2
* Condition 3
* Condition 4
* Condition 5
|warnings======Conidition 1=====
 
(Description)
 
|clinicalTrials=======Central Nervous System======
 
: (list/description of adverse reactions)
 
======Cardiovascular======
 
: (list/description of adverse reactions)
 
======Respiratory======
 
: (list/description of adverse reactions)
 
======Gastrointestinal======
 
: (list/description of adverse reactions)
 
======Hypersensitive Reactions======
 
: (list/description of adverse reactions)
 
======Miscellaneous======
 
: (list/description of adverse reactions)
 
=====Condition 2=====
 
======Central Nervous System======
 
: (list/description of adverse reactions)
 
======Cardiovascular======
 
: (list/description of adverse reactions)
 
======Respiratory======
 
: (list/description of adverse reactions)
 
======Gastrointestinal======
 
: (list/description of adverse reactions)
 
======Hypersensitive Reactions======
 
: (list/description of adverse reactions)
 
======Miscellaneous======
 
: (list/description of adverse reactions)
|postmarketing=(Description)
|drugInteractions=* Drug 1
* Drug 2
* Drug 3
* Drug 4
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=====Drug 1=====
 
(Description)
 
=====Drug 2=====
 
(Description)
 
=====Drug 3=====
 
(Description)
 
=====Drug 4=====
 
(Description)
 
=====Drug 5=====
 
(Description)
|useInPregnancyFDA=(Description)
|useInPregnancyAUS=(Description)
|useInLaborDelivery=(Description)
|useInNursing=(Description)
|useInPed=(Description)
|useInGeri=(Description)
|useInGender=(Description)
|useInRace=(Description)
|useInRenalImpair=(Description)
|useInHepaticImpair=(Description)
|useInReproPotential=(Description)
|useInImmunocomp=(Description)
|othersTitle=Others
|useInOthers=(Description)
 
|administration=(Oral/Intravenous/etc)
|monitoring======Condition 1=====
 
(Description regarding monitoring, from ''Warnings'' section)
 
=====Condition 2=====
 
(Description regarding monitoring, from ''Warnings'' section)
 
=====Condition 3=====
 
(Description regarding monitoring, from ''Warnings'' section)
|IVCompat====Solution===
 
====Compatible====
 
* Solution 1
* Solution 2
* Solution 3
 
====Not Tested====
 
* Solution 1
* Solution 2
* Solution 3
 
====Variable====
 
* Solution 1
* Solution 2
* Solution 3
 
====Incompatible====
 
* Solution 1
* Solution 2
* Solution 3
 
===Y-Site===
 
====Compatible====
 
* Solution 1
* Solution 2
* Solution 3
 
====Not Tested====
 
* Solution 1
* Solution 2
* Solution 3
 
====Variable====
 
* Solution 1
* Solution 2
* Solution 3
 
====Incompatible====
 
* Solution 1
* Solution 2
* Solution 3
 
===Admixture===
 
====Compatible====
 
* Solution 1
* Solution 2
* Solution 3
 
====Not Tested====
 
* Solution 1
* Solution 2
* Solution 3
 
====Variable====
 
* Solution 1
* Solution 2
* Solution 3
 
====Incompatible====
 
* Solution 1
* Solution 2
* Solution 3
 
===Syringe===
 
====Compatible====
 
* Solution 1
* Solution 2
* Solution 3
 
====Not Tested====
 
* Solution 1
* Solution 2
* Solution 3
 
====Variable====
 
* Solution 1
* Solution 2
* Solution 3
 
====Incompatible====
 
* Solution 1
* Solution 2
* Solution 3
 
===TPN/TNA===
 
====Compatible====
 
* Solution 1
* Solution 2
* Solution 3
 
====Not Tested====
 
* Solution 1
* Solution 2
* Solution 3
 
====Variable====
 
* Solution 1
* Solution 2
* Solution 3
 
====Incompatible====
 
* Solution 1
* Solution 2
* Solution 3
|overdose====Acute Overdose===
 
====Signs and Symptoms====
 
(Description)
 
====Management====
 
(Description)
 
===Chronic Overdose===


====Signs and Symptoms====


(Description)


==Overview==
====Management====
'''Urokinase''' (Abbokinase), also called urokinase-type Plasminogen Activator (uPA), is a [[serine protease]] ({{EC number|3.4.21.73}}). Urokinase was originally isolated from human [[urine]], but is present in several physiological locations, such as blood stream and the [[extracellular matrix]]. The primary physiological substrate is [[plasminogen]], which is an inactive [[zymogen]] form of the serine protease [[plasmin]]. Activation of plasmin triggers a proteolysis cascade which, depending on the physiological environment participate in [[thrombolysis]] or [[extracellular matrix]] degradation. This links urokinase to vascular diseases and cancer.


== Molecular characteristics ==
(Description)
Urokinase is a 411 [[residue]] [[protein]], consisting of three [[Domain (biology)|domains]]: the serine protease domain, the [[kringle domain]] and the [[growth factor domain]]. Urokinase is synthesized as a zymogen form (prourokinase or single chain urokinase), and is activated by proteolytic cleavage between L158 and I159. The two resulting chains are kept together by a [[disulfide]] bond.
|drugBox={{Drugbox2
| verifiedrevid =  
| IUPAC_name =  
| image =  
| drug_name =


== Interaction partners ==
<!--Clinical data-->
The most important inhibitors of urokinase are the [[serpin]]s [[plasminogen activator inhibitor-1]] (PAI-1) and [[plasminogen activator inhibitor-2]] (PAI-2), which inhibits the protease activity irreversibly. In the extracellular matrix urokinase is tethered to the [[cell membrane]] by its interaction to the [[urokinase receptor]].
| tradename =  
| MedlinePlus =  
| licence_US =  
| pregnancy_AU =  
| pregnancy_US =
| legal_status =
| routes_of_administration =


<gallery>
<!--Pharmacokinetic data-->
Image:Fibrinolysis.png|Fibrinolysis (simplified). Blue arrows denote stimulation, and red arrows inhibition.
| bioavailability =
</gallery>
| metabolism =
| elimination_half-life =
| excretion =


== Urokinase and cancer ==
<!--Identifiers-->
Elevated [[gene expression|expression]] levels of urokinase and several other components of the [[plasminogen activation system]] are found to be correlated with [[tumor]] [[malignancy]]. It is believed that the tissue degradation following plasminogen activation, facilitates tissue invasion and thus contributes to [[metastasis]]. This makes urokinase an attractive [[drug target]] and [[Enzyme inhibitor|inhibitor]]s have been sought to be used as anticancer agents. However incompatibilities between the human and [[murine]] system hampers clinical evaluation of these agents. Through its interaction with the [[urokinase receptor]], urokinase affects several other aspects of cancer biology such as cells adhesion, migration and cellular [[mitotic]] pathways.
| CAS_number_Ref =
| CAS_number =
| ATC_prefix =
| ATC_suffix =
| PubChem =  
| IUPHAR_ligand =  
| DrugBank_Ref =  
| DrugBank =  
| ChemSpiderID_Ref =
| ChemSpiderID =
| UNII_Ref =
| UNII =
| KEGG_Ref =
| KEGG =
| ChEBI_Ref =
| ChEBI =
| ChEMBL_Ref =
| ChEMBL =


== Clinical applications ==
<!--Chemical data-->
Urokinase is used clinically as a [[thrombolysis|thrombolytic]] agent in the treatment of severe or massive [[deep venous thrombosis]], [[pulmonary embolism]], [[myocardial infarction]], and occluded [[intravenous]] or [[dialysis]] cannulas. Recently, [[tissue plasminogen Activator|Alteplase]] has replaced urokinase as a thrombolytic drug in acute infarction.
| C= | H= | N= | O=
| molecular_weight =
| smiles =
| InChI =
| InChIKey =
| StdInChI_Ref =
| StdInChI =
| StdInChIKey_Ref =  
| StdInChIKey =  
| melting_point =  
}}
|mechAction=(Description)
|structure=(Description with picture)
|PD=(Description)
|PK=(Description)
|nonClinToxic=(Description)
|clinicalStudies======Condition 1=====


(Description)


{{Coagulation}}
=====Condition 2=====
{{Serine endopeptidases}}
{{Antithrombotics}}


[[Category:Hematology]]
(Description)
[[Category:Drugs]]
[[Category:EC 3.4.21]]
[[Category:Cardiology]]


[[de:Urokinase]]
=====Condition 3=====
[[it:Attivatore dell'u-plasminogeno]]
[[ja:ウロキナーゼ]]
[[pl:Urokinaza]]


{{WikiDoc Help Menu}}
(Description)
{{WikiDoc Sources}}
|howSupplied=(Description)
|fdaPatientInfo=(Patient Counseling Information)
|nlmPatientInfo=(Link to patient information page)
|lookAlike=* (Paired Confused Name 1a) — (Paired Confused Name 1b)
* (Paired Confused Name 2a) — (Paired Confused Name 2b)
* (Paired Confused Name 3a) — (Paired Confused Name 3b)
|drugShortage=Drug Shortage
}}

Revision as of 13:29, 11 July 2014

Urokinase
Black Box Warning
Adult Indications & Dosage
Pediatric Indications & Dosage
Contraindications
Warnings & Precautions
Adverse Reactions
Drug Interactions
Use in Specific Populations
Administration & Monitoring
Overdosage
Pharmacology
Clinical Studies
How Supplied
Images
Patient Counseling Information
Precautions with Alcohol
Brand Names
Look-Alike Names

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];

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Black Box Warning

Warning Title
See full prescribing information for complete Boxed Warning.
Condition Name: (Content)

Overview

Urokinase is a Adrenergic receptor agonist that is FDA approved for the {{{indicationType}}} of a list of indications, separated by commas.. There is a Black Box Warning for this drug as shown here. Common adverse reactions include a list of adverse reactions, separated by commas..

Adult Indications and Dosage

FDA-Labeled Indications and Dosage (Adult)

Condition 1
  • Dosing Information
  • (Dosage)
Condition 2
  • Dosing Information
  • (Dosage)

Off-Label Use and Dosage (Adult)

Guideline-Supported Use

Condition 1
  • Developed by: (Organisation)
  • Class of Recommendation: (Class) (Link)
  • Strength of Evidence: (Category A/B/C) (Link)
  • Dosing Information/Recommendation
  • (Dosage)
Condition 2
  • Developed by: (Organisation)
  • Class of Recommendation: (Class) (Link)
  • Strength of Evidence: (Category A/B/C) (Link)
  • Dosing Information/Recommendation
  • (Dosage)

Non–Guideline-Supported Use

Condition 1
  • Dosing Information
  • (Dosage)
Condition 2
  • Dosing Information
  • (Dosage)
Condition 3
  • Dosing Information
  • (Dosage)

Pediatric Indications and Dosage

FDA-Labeled Indications and Dosage (Pediatric)

Condition 1
  • Dosing Information
  • (Dosage)
Condition 2
  • Dosing Information
  • (Dosage)

Off-Label Use and Dosage (Pediatric)

Guideline-Supported Use

Condition 1
  • Developed by: (Organisation)
  • Class of Recommendation: (Class) (Link)
  • Strength of Evidence: (Category A/B/C) (Link)
  • Dosing Information/Recommendation
  • (Dosage)
Condition 2
  • Developed by: (Organisation)
  • Class of Recommendation: (Class) (Link)
  • Strength of Evidence: (Category A/B/C) (Link)
  • Dosing Information/Recommendation
  • (Dosage)

Non–Guideline-Supported Use

Condition 1
  • Dosing Information
  • (Dosage)
Condition 2
  • Dosing Information
  • (Dosage)
Condition 3
  • Dosing Information
  • (Dosage)

Contraindications

  • Condition 1
  • Condition 2
  • Condition 3
  • Condition 4
  • Condition 5

Warnings

Warning Title
See full prescribing information for complete Boxed Warning.
Condition Name: (Content)
Conidition 1

(Description)

Adverse Reactions

Clinical Trials Experience

Central Nervous System
(list/description of adverse reactions)
Cardiovascular
(list/description of adverse reactions)
Respiratory
(list/description of adverse reactions)
Gastrointestinal
(list/description of adverse reactions)
Hypersensitive Reactions
(list/description of adverse reactions)
Miscellaneous
(list/description of adverse reactions)
Condition 2
Central Nervous System
(list/description of adverse reactions)
Cardiovascular
(list/description of adverse reactions)
Respiratory
(list/description of adverse reactions)
Gastrointestinal
(list/description of adverse reactions)
Hypersensitive Reactions
(list/description of adverse reactions)
Miscellaneous
(list/description of adverse reactions)

Postmarketing Experience

(Description)

Drug Interactions

  • Drug 1
  • Drug 2
  • Drug 3
  • Drug 4
  • Drug 5
Drug 1

(Description)

Drug 2

(Description)

Drug 3

(Description)

Drug 4

(Description)

Drug 5

(Description)

Use in Specific Populations

Pregnancy

Pregnancy Category (FDA): (Description)
Pregnancy Category (AUS): (Description)

Labor and Delivery

(Description)

Nursing Mothers

(Description)

Pediatric Use

(Description)

Geriatic Use

(Description)

Gender

(Description)

Race

(Description)

Renal Impairment

(Description)

Hepatic Impairment

(Description)

Females of Reproductive Potential and Males

(Description)

Immunocompromised Patients

(Description)

Others

(Description)

Administration and Monitoring

Administration

(Oral/Intravenous/etc)

Monitoring

Condition 1

(Description regarding monitoring, from Warnings section)

Condition 2

(Description regarding monitoring, from Warnings section)

Condition 3

(Description regarding monitoring, from Warnings section)

IV Compatibility

Solution

Compatible

  • Solution 1
  • Solution 2
  • Solution 3

Not Tested

  • Solution 1
  • Solution 2
  • Solution 3

Variable

  • Solution 1
  • Solution 2
  • Solution 3

Incompatible

  • Solution 1
  • Solution 2
  • Solution 3

Y-Site

Compatible

  • Solution 1
  • Solution 2
  • Solution 3

Not Tested

  • Solution 1
  • Solution 2
  • Solution 3

Variable

  • Solution 1
  • Solution 2
  • Solution 3

Incompatible

  • Solution 1
  • Solution 2
  • Solution 3

Admixture

Compatible

  • Solution 1
  • Solution 2
  • Solution 3

Not Tested

  • Solution 1
  • Solution 2
  • Solution 3

Variable

  • Solution 1
  • Solution 2
  • Solution 3

Incompatible

  • Solution 1
  • Solution 2
  • Solution 3

Syringe

Compatible

  • Solution 1
  • Solution 2
  • Solution 3

Not Tested

  • Solution 1
  • Solution 2
  • Solution 3

Variable

  • Solution 1
  • Solution 2
  • Solution 3

Incompatible

  • Solution 1
  • Solution 2
  • Solution 3

TPN/TNA

Compatible

  • Solution 1
  • Solution 2
  • Solution 3

Not Tested

  • Solution 1
  • Solution 2
  • Solution 3

Variable

  • Solution 1
  • Solution 2
  • Solution 3

Incompatible

  • Solution 1
  • Solution 2
  • Solution 3

Overdosage

Acute Overdose

Signs and Symptoms

(Description)

Management

(Description)

Chronic Overdose

Signs and Symptoms

(Description)

Management

(Description)

Pharmacology

Urokinase
Systematic (IUPAC) name
?
Identifiers
CAS number ?
ATC code ?
PubChem ?
Chemical data
Formula ?
Mol. mass ?
Pharmacokinetic data
Bioavailability ?
Metabolism ?
Half life ?
Excretion ?
Therapeutic considerations
Pregnancy cat.

?

Legal status
Routes ?

Mechanism of Action

(Description)

Structure

(Description with picture)

Pharmacodynamics

(Description)

Pharmacokinetics

(Description)

Nonclinical Toxicology

(Description)

Clinical Studies

Condition 1

(Description)

Condition 2

(Description)

Condition 3

(Description)

How Supplied

(Description)

Storage

There is limited information regarding Urokinase Storage in the drug label.

Images

Drug Images

{{#ask: Page Name::Urokinase |?Pill Name |?Drug Name |?Pill Ingred |?Pill Imprint |?Pill Dosage |?Pill Color |?Pill Shape |?Pill Size (mm) |?Pill Scoring |?NDC |?Drug Author |format=template |template=DrugPageImages |mainlabel=- |sort=Pill Name }}

Package and Label Display Panel

{{#ask: Label Page::Urokinase |?Label Name |format=template |template=DrugLabelImages |mainlabel=- |sort=Label Page }}

Patient Counseling Information

(Patient Counseling Information)

Precautions with Alcohol

Alcohol-Urokinase interaction has not been established. Talk to your doctor regarding the effects of taking alcohol with this medication.

Brand Names

There is limited information regarding Urokinase Brand Names in the drug label.

Look-Alike Drug Names

  • (Paired Confused Name 1a) — (Paired Confused Name 1b)
  • (Paired Confused Name 2a) — (Paired Confused Name 2b)
  • (Paired Confused Name 3a) — (Paired Confused Name 3b)

Drug Shortage Status

Drug Shortage

Price

References

The contents of this FDA label are provided by the National Library of Medicine.

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