Activated clotting time

Not to be confused with ACT trial.

WikiDoc Resources for Activated clotting time
Articles
Most recent articles on Activated clotting time Most cited articles on Activated clotting time Review articles on Activated clotting time Articles on Activated clotting time in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on Activated clotting time Images of Activated clotting time Photos of Activated clotting time Podcasts & MP3s on Activated clotting time Videos on Activated clotting time
Evidence Based Medicine
Cochrane Collaboration on Activated clotting time Bandolier on Activated clotting time TRIP on Activated clotting time
Clinical Trials
Ongoing Trials on Activated clotting time at Clinical Trials.gov Trial results on Activated clotting time Clinical Trials on Activated clotting time at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Activated clotting time NICE Guidance on Activated clotting time NHS PRODIGY Guidance FDA on Activated clotting time CDC on Activated clotting time
Books
Books on Activated clotting time
News
Activated clotting time in the news Be alerted to news on Activated clotting time News trends on Activated clotting time
Commentary
Blogs on Activated clotting time
Definitions
Definitions of Activated clotting time
Patient Resources / Community
Patient resources on Activated clotting time Discussion groups on Activated clotting time Patient Handouts on Activated clotting time Directions to Hospitals Treating Activated clotting time Risk calculators and risk factors for Activated clotting time
Healthcare Provider Resources
Symptoms of Activated clotting time Causes & Risk Factors for Activated clotting time Diagnostic studies for Activated clotting time Treatment of Activated clotting time
Continuing Medical Education (CME)
CME Programs on Activated clotting time
International
Activated clotting time en Espanol Activated clotting time en Francais
Business
Activated clotting time in the Marketplace Patents on Activated clotting time
Experimental / Informatics
List of terms related to Activated clotting time

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Synonyms and keywords: ACT

Overview

The activated clotting time (ACT) was introduced during the 1970s as a test to monitor the administration and subsequent reversal of unfractionated heparin (UFH) during coronary artery bypass graft surgery. Currently the test is widely used in the cardiac catheterization laboratory to monitor the adequacy of UFH dosing. The unit of measure is in seconds.

Titration of UFH dosing based upon the ACT

While practice patterns in Europe are such that a large single dose of UFH is often administered for a percutaneous coronary intervention (PCI) (150 Units/per Kg), in the United States, lower doses of UFH (35 to 70U/kg depending upon the operator) are administered, and subsequent doses of UFH are titrated based upon the ACT. In the absence of a glycoprotein 2b3a inhbitor, the target ACT is usually 250 to 300 seconds. If a glycoprotein 2b3a inhibitor has been administered, the target ACT is lower, at 200 to 250 seconds.

Relationship of the ACT to clinical outcomes

Despite the aggressive use of ACT monitoring, there is scant data to relate the peak ACT to efficacy or bleeding outcomes in the setting of PCI. CME Category::Cardiology