Atorvastatin drug interactions: Difference between revisions
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{{CMG}}; {{AE}} {{PB}} | {{CMG}}; {{AE}} {{PB}} | ||
The risk of [[myopathy]] during treatment with statins is increased with concurrent administration of fibric acid derivatives, lipid-modifying doses of [[niacin]], [[cyclosporine]], or strong CYP 3A4 inhibitors (e.g., [[clarithromycin]], HIV protease inhibitors, and [[itraconazole]]) [see Warnings and Precautions, Skeletal Muscle (5.1) and Clinical Pharmacology (12.3)]. | |||
The risk of [[myopathy]] during treatment with statins is increased with concurrent administration of fibric acid derivatives, lipid-modifying doses of [[niacin]], [[cyclosporine]], or strong CYP 3A4 inhibitors (e.g., [[clarithromycin]], | |||
====Strong Inhibitors of CYP 3A4==== | ====Strong Inhibitors of CYP 3A4==== | ||
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Atorvastatin is metabolized by cytochrome P450 3A4. Concomitant administration of Atorvastatin with strong inhibitors of CYP 3A4 can lead to increases in plasma concentrations of atorvastatin. The extent of interaction and potentiation of effects depend on the variability of effect on CYP 3A4. | Atorvastatin is metabolized by cytochrome P450 3A4. Concomitant administration of Atorvastatin with strong inhibitors of CYP 3A4 can lead to increases in plasma concentrations of atorvastatin. The extent of interaction and potentiation of effects depend on the variability of effect on CYP 3A4. | ||
==== | ====Clarithromycin==== | ||
Atorvastatin AUC was significantly increased with concomitant administration of Atorvastatin 80 mg with [[clarithromycin]] (500 mg twice daily) compared to that of Atorvastatin alone [see Clinical Pharmacology (12.3)]. Therefore, in patients taking [[clarithromycin]], caution should be used when the Atorvastatin dose exceeds 20 mg [see Warnings and Precautions, Skeletal Muscle (5.1) and Dosage and Administration (2.6)]. | Atorvastatin AUC was significantly increased with concomitant administration of Atorvastatin 80 mg with [[clarithromycin]] (500 mg twice daily) compared to that of Atorvastatin alone [see Clinical Pharmacology (12.3)]. Therefore, in patients taking [[clarithromycin]], caution should be used when the Atorvastatin dose exceeds 20 mg [see Warnings and Precautions, Skeletal Muscle (5.1) and Dosage and Administration (2.6)]. | ||
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====Combination of Protease Inhibitors==== | ====Combination of Protease Inhibitors==== | ||
Atorvastatin AUC was significantly increased with concomitant administration of Atorvastatin with several combinations of HIV protease inhibitors, as well as with the hepatitis C protease inhibitor telaprevir, compared to that of Atorvastatin alone [see Clinical Pharmacology (12.3)]. Therefore, in patients taking the | Atorvastatin AUC was significantly increased with concomitant administration of Atorvastatin with several combinations of HIV protease inhibitors, as well as with the hepatitis C protease inhibitor telaprevir, compared to that of Atorvastatin alone [see Clinical Pharmacology (12.3)]. Therefore, in patients taking the HIV protease inhibitor [[tipranavir]] plus [[ritonavir]], or the [[hepatitis C]] protease inhibitor [[telaprevir]], concomitant use of Atorvastatin should be avoided. In patients taking the HIV protease inhibitor lopinavir plus [[ritonavir]], caution should be used when prescribing Atorvastatin and the lowest dose necessary should be used. In patients taking the [[HIV protease inhibitors]] [[saquinavir]] plus [[ritonavir]], [[darunavi]]r plus [[ritonavir]], [[fosamprenavir]], or [[fosamprenavir]] plus ritonavir, the dose of Atorvastatin should not exceed 20 mg and should be used with caution [see Warnings and Precautions, Skeletal Muscle (5.1) and Dosage and Administration (2.6)]. In patients taking the HIV protease inhibitor [[nelfinavir]] or the [[hepatitis C]] protease inhibitor [[boceprevir]], the dose of Atorvastatin should not exceed 40 mg and close clinical monitoring is recommended. | ||
==== | ====Itraconazole==== | ||
Atorvastatin AUC was significantly increased with concomitant administration of Atorvastatin 40 mg and [[itraconazole]] 200 mg [see Clinical Pharmacology (12.3)]. Therefore, in patients taking [[itraconazole]], caution should be used when the Atorvastatin dose exceeds 20 mg [see Warnings and Precautions, Skeletal Muscle (5.1) and Dosage and Administration (2.6)]. | Atorvastatin AUC was significantly increased with concomitant administration of Atorvastatin 40 mg and [[itraconazole]] 200 mg [see Clinical Pharmacology (12.3)]. Therefore, in patients taking [[itraconazole]], caution should be used when the Atorvastatin dose exceeds 20 mg [see Warnings and Precautions, Skeletal Muscle (5.1) and Dosage and Administration (2.6)]. | ||
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====Grapefruit Juice==== | ====Grapefruit Juice==== | ||
Contains one or more components that inhibit CYP 3A4 and can increase plasma concentrations of atorvastatin, especially with excessive grapefruit juice consumption (>1.2 liters per day). | Contains one or more components that inhibit [[CYP 3A4]] and can increase plasma concentrations of atorvastatin, especially with excessive grapefruit juice consumption (>1.2 liters per day). | ||
==== | ====Cyclosporine==== | ||
Atorvastatin and atorvastatin-metabolites are substrates of the OATP1B1 transporter. Inhibitors of the OATP1B1 (e.g., [[cyclosporine]]) can increase the bioavailability of atorvastatin. Atorvastatin AUC was significantly increased with concomitant administration of Atorvastatin 10 mg and [[cyclosporine]] 5.2 mg/kg/day compared to that of Atorvastatin alone [see Clinical Pharmacology (12.3)]. The co-administration of Atorvastatin with cyclosporine should be avoided [see Warnings and Precautions, Skeletal Muscle (5.1)]. | Atorvastatin and atorvastatin-metabolites are substrates of the OATP1B1 transporter. Inhibitors of the OATP1B1 (e.g., [[cyclosporine]]) can increase the bioavailability of atorvastatin. Atorvastatin AUC was significantly increased with concomitant administration of Atorvastatin 10 mg and [[cyclosporine]] 5.2 mg/kg/day compared to that of Atorvastatin alone [see Clinical Pharmacology (12.3)]. The co-administration of Atorvastatin with [[cyclosporine]] should be avoided [see Warnings and Precautions, Skeletal Muscle (5.1)]. | ||
==== | ====Gemfibrozil==== | ||
Due to an increased risk of myopathy/rhabdomyolysis when [[HMG-CoA reductase]] inhibitors are co-administered with gemfibrozil, concomitant administration of Atorvastatin with [[gemfibrozil]] should be avoided [see Warnings and Precautions (5.1)]. | Due to an increased risk of myopathy/rhabdomyolysis when [[HMG-CoA reductase]] inhibitors are co-administered with gemfibrozil, concomitant administration of Atorvastatin with [[gemfibrozil]] should be avoided [see Warnings and Precautions (5.1)]. | ||
====Other | ====Other Fibrates==== | ||
Because it is known that the risk of [[myopathy]] during treatment with [[HMG-CoA reductase]] inhibitors is increased with concurrent administration of other fibrates, Atorvastatin should be administered with caution when used concomitantly with other fibrates [see Warnings and Precautions (5.1)]. | Because it is known that the risk of [[myopathy]] during treatment with [[HMG-CoA reductase]] inhibitors is increased with concurrent administration of other fibrates, Atorvastatin should be administered with caution when used concomitantly with other fibrates [see Warnings and Precautions (5.1)]. | ||
==== | ====Niacin==== | ||
The risk of skeletal muscle effects may be enhanced when Atorvastatin is used in combination with niacin; a reduction in Atorvastatin dosage should be considered in this setting [see Warnings and Precautions (5.1)]. | The risk of skeletal muscle effects may be enhanced when Atorvastatin is used in combination with niacin; a reduction in Atorvastatin dosage should be considered in this setting [see Warnings and Precautions (5.1)]. | ||
==== | ====Rifampin or other Inducers of Cytochrome P450 3A4==== | ||
Concomitant administration of Atorvastatin with inducers of cytochrome P450 3A4 (e.g., [[efavirenz]], [[rifampin]]) can lead to variable reductions in plasma concentrations of atorvastatin. Due to the dual interaction mechanism of rifampin, simultaneous co-administration of Atorvastatin with rifampin is recommended, as delayed administration of Atorvastatin after administration of rifampin has been associated with a significant reduction in atorvastatin plasma concentrations. | Concomitant administration of Atorvastatin with inducers of [[cytochrome P450 3A4]] (e.g., [[efavirenz]], [[rifampin]]) can lead to variable reductions in plasma concentrations of atorvastatin. Due to the dual interaction mechanism of rifampin, simultaneous co-administration of Atorvastatin with rifampin is recommended, as delayed administration of Atorvastatin after administration of rifampin has been associated with a significant reduction in atorvastatin plasma concentrations. | ||
==== | ====Digoxin==== | ||
When multiple doses of Atorvastatin and [[digoxin]] were co-administered, steady state plasma digoxin concentrations increased by approximately 20%. Patients taking digoxin should be monitored appropriately. | When multiple doses of Atorvastatin and [[digoxin]] were co-administered, steady state plasma [[digoxin]] concentrations increased by approximately 20%. Patients taking digoxin should be monitored appropriately. | ||
==== | ==== Oral Contraceptives==== | ||
Co-administration of Atorvastatin and an oral contraceptive increased AUC values for norethindrone and [[ethinyl estradiol]] [see Clinical Pharmacology (12.3)]. These increases should be considered when selecting an oral contraceptive for a woman taking Atorvastatin. | Co-administration of Atorvastatin and an oral contraceptive increased AUC values for norethindrone and [[ethinyl estradiol]] [see Clinical Pharmacology (12.3)]. These increases should be considered when selecting an oral contraceptive for a woman taking Atorvastatin. | ||
==== | ====Warfarin==== | ||
Atorvastatin had no clinically significant effect on [[prothrombin time]] when administered to patients receiving chronic [[warfarin]] treatment. | |||
====Colchicine==== | |||
==== | |||
Cases of [[myopathy]], including [[rhabdomyolysis]], have been reported with atorvastatin co-administered with [[colchicine]], and caution should be exercised when prescribing atorvastatin with [[colchicine]].<ref name="dailymed.nlm.nih.gov">{{Cite web | last = |first = | title = LIPITOR (ATORVASTATIN CALCIUM) TABLET, FILM COATED [PARKE-DAVIS DIV OF PFIZER INC] | url =http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=c6e131fe-e7df-4876-83f7-9156fc4e8228#nlm34089-3 | publisher = | date = | accessdate = }}</ref> | Cases of [[myopathy]], including [[rhabdomyolysis]], have been reported with atorvastatin co-administered with [[colchicine]], and caution should be exercised when prescribing atorvastatin with [[colchicine]].<ref name="dailymed.nlm.nih.gov">{{Cite web | last = |first = | title = LIPITOR (ATORVASTATIN CALCIUM) TABLET, FILM COATED [PARKE-DAVIS DIV OF PFIZER INC] | url =http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=c6e131fe-e7df-4876-83f7-9156fc4e8228#nlm34089-3 | publisher = | date = | accessdate = }}</ref> | ||
==Major Interactions== | ==Major Interactions== | ||
{{refbegin|3}} | {{refbegin|3}} | ||
* [[Agenerase]] | * [[Agenerase]] | ||
* [[amprenavir]] | * [[amprenavir]] | ||
* [[Antara]] | * [[Antara]] | ||
* [[Aptivus]] | * [[Aptivus]] | ||
* [[atazanavir]] | * [[atazanavir]] | ||
* [[Atromid-S]] | * [[Atromid-S]] | ||
* [[B-3-50]] | * [[B-3-50]] | ||
* [[B3-500-Gr]] | * [[B3-500-Gr]] | ||
* [[Biaxin]] | * [[Biaxin]] | ||
* [[Biaxin XL]] | * [[Biaxin XL]] | ||
* [[Biaxin XL-Pak]] | * [[Biaxin XL-Pak]] | ||
* [[clarithromycin]] | * [[clarithromycin]] | ||
* [[clarithromycin extended release]] | * [[clarithromycin extended release]] | ||
* [[clofibrate]] | * [[clofibrate]] | ||
* [[clotrimazole]] | * [[clotrimazole]] | ||
* [[conivaptan]] | * [[conivaptan]] | ||
* [[Crixivan]] | * [[Crixivan]] | ||
* [[cyclosporine]] | * [[cyclosporine]] | ||
* [[danazol]] | * [[danazol]] | ||
* [[Danocrine]] | * [[Danocrine]] | ||
* [[Diflucan]] | * [[Diflucan]] | ||
* [[Dom-Fenofibrate]] | * [[Dom-Fenofibrate]] | ||
* [[E-Mycin]] | * [[E-Mycin]] | ||
* [[E.E.S. Granules]] | * [[E.E.S. Granules]] | ||
* [[E.E.S.-200]] | * [[E.E.S.-200]] | ||
* [[E.E.S.-400]] | * [[E.E.S.-400]] | ||
* [[E.E.S.-400 Filmtab]] | * [[E.E.S.-400 Filmtab]] | ||
* [[Ery-Tab]] | * [[Ery-Tab]] | ||
* [[Eryc]] | * [[Eryc]] | ||
* [[EryPed]] | * [[EryPed]] | ||
* [[EryPed 200]] | * [[EryPed 200]] | ||
* [[EryPed 400]] | * [[EryPed 400]] | ||
* [[Erythrocin Lactobionate]] | * [[Erythrocin Lactobionate]] | ||
* [[Erythrocin Stearate Filmtab]] | * [[Erythrocin Stearate Filmtab]] | ||
* [[Erythrocot]] | * [[Erythrocot]] | ||
* [[erythromycin]] | * [[erythromycin]] | ||
* [[erythromycin base]] | * [[erythromycin base]] | ||
* [[erythromycin estolate]] | * [[erythromycin estolate]] | ||
* [[erythromycin ethylsuccinate]] | * [[erythromycin ethylsuccinate]] | ||
* [[erythromycin lactobionate]] | * [[erythromycin lactobionate]] | ||
* [[erythromycin stearate]] | * [[erythromycin stearate]] | ||
* [[fenofibrate]] | * [[fenofibrate]] | ||
* [[Fenoglide]] | * [[Fenoglide]] | ||
* [[fluconazole]] | * [[fluconazole]] | ||
* [[Fortovase]] | * [[Fortovase]] | ||
* [[fosamprenavir]] | * [[fosamprenavir]] | ||
* [[gemfibrozil]] | * [[gemfibrozil]] | ||
* [[Gengraf]] | * [[Gengraf]] | ||
* [[Ilosone]] | * [[Ilosone]] | ||
* [[Ilotycin Gluceptate]] | * [[Ilotycin Gluceptate]] | ||
* [[indinavir]] | * [[indinavir]] | ||
* [[Invirase]] | * [[Invirase]] | ||
* [[itraconazole]] | * [[itraconazole]] | ||
* [[Ketek]] | * [[Ketek]] | ||
* [[Ketek Pak]] | * [[Ketek Pak]] | ||
* [[ketoconazole]] | * [[ketoconazole]] | ||
* [[Lexiva]] | * [[Lexiva]] | ||
* [[Lipidil EZ]] | * [[Lipidil EZ]] | ||
* [[Lipidil Micro]] | * [[Lipidil Micro]] | ||
* [[Lipidil Supra]] | * [[Lipidil Supra]] | ||
* [[Lipofen]] | * [[Lipofen]] | ||
* [[Lofibra]] | * [[Lofibra]] | ||
* [[Lopid]] | * [[Lopid]] | ||
* [[mibefradil]] | * [[mibefradil]] | ||
* [[miconazole]] | * [[miconazole]] | ||
* [[Monistat I.V.]] | * [[Monistat I.V.]] | ||
* [[MY-E]] | * [[MY-E]] | ||
* [[Mycelex Troche]] | * [[Mycelex Troche]] | ||
* [[nefazodone]] | * [[nefazodone]] | ||
* [[nelfinavir]] | * [[nelfinavir]] | ||
* [[Neoral]] | * [[Neoral]] | ||
* [[niacin]] | * [[niacin]] | ||
* [[niacin extended release]] | * [[niacin extended release]] | ||
* [[Niacin SR]] | * [[Niacin SR]] | ||
* [[Niacor]] | * [[Niacor]] | ||
* [[Niacor B3]] | * [[Niacor B3]] | ||
* [[Niaspan ER]] | * [[Niaspan ER]] | ||
* [[Niaspan ER Starter Pack]] | * [[Niaspan ER Starter Pack]] | ||
* [[Nico-400]] | * [[Nico-400]] | ||
* [[Nicobid Tempules]] | * [[Nicobid Tempules]] | ||
* [[Nicolar]] | * [[Nicolar]] | ||
* [[Nicotinex]] | * [[Nicotinex]] | ||
* [[Nicotinic Acid]] | * [[Nicotinic Acid]] | ||
* [[Nizoral]] | * [[Nizoral]] | ||
* [[Norvir]] | * [[Norvir]] | ||
* [[Norvir Soft Gelatin]] | * [[Norvir Soft Gelatin]] | ||
* [[Noxafil]] | * [[Noxafil]] | ||
* [[PCE Dispertab]] | * [[PCE Dispertab]] | ||
* [[posaconazole]] | * [[posaconazole]] | ||
* [[Posicor]] | * [[Posicor]] | ||
* [[Reyataz]] | * [[Reyataz]] | ||
* [[ritonavir]] | * [[ritonavir]] | ||
* [[Robimycin]] | * [[Robimycin]] | ||
* [[Sandimmune]] | * [[Sandimmune]] | ||
* [[saquinavir]] | * [[saquinavir]] | ||
* [[saquinavir mesylate]] | * [[saquinavir mesylate]] | ||
* [[Serzone]] | * [[Serzone]] | ||
* [[Slo-Niacin]] | * [[Slo-Niacin]] | ||
* [[Sporanox]] | * [[Sporanox]] | ||
* [[Tao]] | * [[Tao]] | ||
* [[telithromycin]] | * [[telithromycin]] | ||
* [[Telzir]] | * [[Telzir]] | ||
* [[tipranavir]] | * [[tipranavir]] | ||
* [[TriCor]] | * [[TriCor]] | ||
* [[Triglide]] | * [[Triglide]] | ||
* [[troleandomycin]] | * [[troleandomycin]] | ||
* [[Vaprisol]] | * [[Vaprisol]] | ||
* [[Viracept]] | * [[Viracept]] | ||
* [[vitamin B3]] | * [[vitamin B3]] | ||
{{refend}} | {{refend}} | ||
| Line 177: | Line 176: | ||
==Moderate Interactions== | ==Moderate Interactions== | ||
{{refbegin|3}} | {{refbegin|3}} | ||
* [[8-Mop]] | * [[8-Mop]] | ||
* [[Abraxane]] | * [[Abraxane]] | ||
* [[Accolate]] | * [[Accolate]] | ||
* [[Adalat]] | * [[Adalat]] | ||
* [[Adalat CC]] | * [[Adalat CC]] | ||
* [[Afeditab CR]] | * [[Afeditab CR]] | ||
* [[aliskiren]] | * [[aliskiren]] | ||
* [[aminolevulinic acid topical]] | * [[aminolevulinic acid topical]] | ||
* [[amiodarone]] | * [[amiodarone]] | ||
* [[Antabuse]] | * [[Antabuse]] | ||
* [[aprepitant]] | * [[aprepitant]] | ||
* [[Arava]] | * [[Arava]] | ||
* [[Arranon]] | * [[Arranon]] | ||
* [[Avonex]] | * [[Avonex]] | ||
* [[Avonex Prefilled Syringe]] | * [[Avonex Prefilled Syringe]] | ||
* [[azithromycin]] | * [[azithromycin]] | ||
* [[Azithromycin 3 Day Dose Pack]] | * [[Azithromycin 3 Day Dose Pack]] | ||
* [[Azithromycin 5 Day Dose Pack]] | * [[Azithromycin 5 Day Dose Pack]] | ||
* [[azithromycin extended release]] | * [[azithromycin extended release]] | ||
* [[AZT]] | * [[AZT]] | ||
* [[Betaseron]] | * [[Betaseron]] | ||
* [[bortezomib]] | * [[bortezomib]] | ||
* [[bosentan]] | * [[bosentan]] | ||
* [[bromocriptine]] | * [[bromocriptine]] | ||
* [[Calan]] | * [[Calan]] | ||
* [[Calan SR]] | * [[Calan SR]] | ||
* [[carboplatin]] | * [[carboplatin]] | ||
* [[Carboplatin Novaplus]] | * [[Carboplatin Novaplus]] | ||
* [[Cardizem]] | * [[Cardizem]] | ||
* [[Cardizem CD]] | * [[Cardizem CD]] | ||
* [[Cardizem LA]] | * [[Cardizem LA]] | ||
* [[Cardizem Monovial]] | * [[Cardizem Monovial]] | ||
* [[Cardizem SR]] | * [[Cardizem SR]] | ||
* [[Cardoxin]] | * [[Cardoxin]] | ||
* [[Cartia XT]] | * [[Cartia XT]] | ||
* [[Chloracol]] | * [[Chloracol]] | ||
* [[chloramphenicol]] | * [[chloramphenicol]] | ||
* [[Chloromycetin]] | * [[Chloromycetin]] | ||
* [[Chloromycetin Sodium Succinate]] | * [[Chloromycetin Sodium Succinate]] | ||
* [[cholestyramine]] | * [[cholestyramine]] | ||
* [[Cholestyramine Light]] | * [[Cholestyramine Light]] | ||
* [[cisplatin]] | * [[cisplatin]] | ||
* [[clofarabine]] | * [[clofarabine]] | ||
* [[Clolar]] | * [[Clolar]] | ||
* [[clopidogrel]] | * [[clopidogrel]] | ||
* [[Cordarone]] | * [[Cordarone]] | ||
* [[Cordarone I.V.]] | * [[Cordarone I.V.]] | ||
* [[Covera-HS]] | * [[Covera-HS]] | ||
* [[Cubicin]] | * [[Cubicin]] | ||
* [[D.H.E. 45]] | * [[D.H.E. 45]] | ||
* [[d4T]] | * [[d4T]] | ||
* [[dalfopristin]] | * [[dalfopristin]] | ||
* [[daptomycin]] | * [[daptomycin]] | ||
* [[darunavir]] | * [[darunavir]] | ||
* [[dasatinib]] | * [[dasatinib]] | ||
* [[ddC]] | * [[ddC]] | ||
* [[ddI]] | * [[ddI]] | ||
* [[delavirdine]] | * [[delavirdine]] | ||
* [[didanosine]] | * [[didanosine]] | ||
* [[didanosine delayed release capsule]] | * [[didanosine delayed release capsule]] | ||
* [[Digitek]] | * [[Digitek]] | ||
* [[digoxin]] | * [[digoxin]] | ||
* [[digoxin capsule]] | * [[digoxin capsule]] | ||
* [[dihydroergotamine]] | * [[dihydroergotamine]] | ||
* [[dihydroergotamine nasal]] | * [[dihydroergotamine nasal]] | ||
* [[Dilacor XR]] | * [[Dilacor XR]] | ||
* [[Diltia XT]] | * [[Diltia XT]] | ||
* [[diltiazem]] | * [[diltiazem]] | ||
* [[diltiazem 24 hour extended release]] | * [[diltiazem 24 hour extended release]] | ||
* [[diltiazem extended release]] | * [[diltiazem extended release]] | ||
* [[Diltiazem Hydrochloride CD]] | * [[Diltiazem Hydrochloride CD]] | ||
* [[Diltiazem Hydrochloride SR]] | * [[Diltiazem Hydrochloride SR]] | ||
* [[Diltiazem Hydrochloride XR]] | * [[Diltiazem Hydrochloride XR]] | ||
* [[Diltiazem Hydrochloride XT]] | * [[Diltiazem Hydrochloride XT]] | ||
* [[Diquinol]] | * [[Diquinol]] | ||
* [[disulfiram]] | * [[disulfiram]] | ||
* [[docetaxel]] | * [[docetaxel]] | ||
* [[echinacea]] | * [[echinacea]] | ||
* [[efavirenz]] | * [[efavirenz]] | ||
* [[Eloxatin]] | * [[Eloxatin]] | ||
* [[Emend]] | * [[Emend]] | ||
* [[Emend 3-Day]] | * [[Emend 3-Day]] | ||
* [[Emend for Injection]] | * [[Emend for Injection]] | ||
* [[Ergomar]] | * [[Ergomar]] | ||
* [[ergotamine]] | * [[ergotamine]] | ||
* [[esomeprazole]] | * [[esomeprazole]] | ||
* [[etravirine]] | * [[etravirine]] | ||
* [[ezetimibe]] | * [[ezetimibe]] | ||
* [[Fasigyn]] | * [[Fasigyn]] | ||
* [[FK506]] | * [[FK506]] | ||
* [[Flagyl]] | * [[Flagyl]] | ||
* [[Flagyl 375]] | * [[Flagyl 375]] | ||
* [[Flagyl ER]] | * [[Flagyl ER]] | ||
* [[Flagyl I.V.]] | * [[Flagyl I.V.]] | ||
* [[Flagyl I.V. RTU]] | * [[Flagyl I.V. RTU]] | ||
* [[fluvoxamine]] | * [[fluvoxamine]] | ||
* [[fluvoxamine extended release]] | * [[fluvoxamine extended release]] | ||
* [[Folex PFS]] | * [[Folex PFS]] | ||
* [[fosaprepitant]] | * [[fosaprepitant]] | ||
* [[Furadantin]] | * [[Furadantin]] | ||
* [[Gleevec]] | * [[Gleevec]] | ||
* [[goldenseal]] | * [[goldenseal]] | ||
* [[grepafloxacin]] | * [[grepafloxacin]] | ||
* [[Hivid]] | * [[Hivid]] | ||
* [[hypericum perforatum]] | * [[hypericum perforatum]] | ||
* [[imatinib]] | * [[imatinib]] | ||
* [[INH]] | * [[INH]] | ||
* [[Intelence]] | * [[Intelence]] | ||
* [[interferon beta-1a]] | * [[interferon beta-1a]] | ||
* [[interferon beta-1b]] | * [[interferon beta-1b]] | ||
* [[iodoquinol]] | * [[iodoquinol]] | ||
* [[isoniazid]] | * [[isoniazid]] | ||
* [[Isoptin]] | * [[Isoptin]] | ||
* [[Isoptin I.V.]] | * [[Isoptin I.V.]] | ||
* [[Isoptin SR]] | * [[Isoptin SR]] | ||
* [[ixabepilone]] | * [[ixabepilone]] | ||
* [[Ixempra]] | * [[Ixempra]] | ||
* [[Lanoxicaps]] | * [[Lanoxicaps]] | ||
* [[Lanoxin]] | * [[Lanoxin]] | ||
* [[lanreotide]] | * [[lanreotide]] | ||
* [[lansoprazole]] | * [[lansoprazole]] | ||
* [[lapatinib]] | * [[lapatinib]] | ||
* [[leflunomide]] | * [[leflunomide]] | ||
* [[Levulan Kerastick]] | * [[Levulan Kerastick]] | ||
* [[Luvox]] | * [[Luvox]] | ||
* [[Luvox CR]] | * [[Luvox CR]] | ||
* [[Macrobid]] | * [[Macrobid]] | ||
* [[Macrodantin]] | * [[Macrodantin]] | ||
* [[methotrexate]] | * [[methotrexate]] | ||
* [[Methotrexate Sodium Preservative Free]] | * [[Methotrexate Sodium Preservative Free]] | ||
* [[methoxsalen]] | * [[methoxsalen]] | ||
* [[Metro I.V.]] | * [[Metro I.V.]] | ||
* [[metronidazole]] | * [[metronidazole]] | ||
* [[metronidazole extended release]] | * [[metronidazole extended release]] | ||
* [[Metryl]] | * [[Metryl]] | ||
* [[midazolam]] | * [[midazolam]] | ||
* [[Mifeprex]] | * [[Mifeprex]] | ||
* [[mifepristone]] | * [[mifepristone]] | ||
* [[Migranal]] | * [[Migranal]] | ||
* [[naltrexone]] | * [[naltrexone]] | ||
* [[Navelbine]] | * [[Navelbine]] | ||
* [[nelarabine]] | * [[nelarabine]] | ||
* [[nevirapine]] | * [[nevirapine]] | ||
* [[Nexium]] | * [[Nexium]] | ||
* [[Nexium I.V.]] | * [[Nexium I.V.]] | ||
* [[Nifediac CC]] | * [[Nifediac CC]] | ||
* [[Nifedical XL]] | * [[Nifedical XL]] | ||
* [[Nifedipine]] | * [[Nifedipine]] | ||
* [[Nifedipine extended release]] | * [[Nifedipine extended release]] | ||
* [[nilotinib]] | * [[nilotinib]] | ||
* [[Nitro Macro]] | * [[Nitro Macro]] | ||
* [[nitrofurantoin]] | * [[nitrofurantoin]] | ||
* [[nitrofurantoin dual release]] | * [[nitrofurantoin dual release]] | ||
* [[nitrofurantoin macrocrystals]] | * [[nitrofurantoin macrocrystals]] | ||
* [[nitrofurantoin regular release]] | * [[nitrofurantoin regular release]] | ||
* [[Nydrazid]] | * [[Nydrazid]] | ||
* [[octreotide]] | * [[octreotide]] | ||
* [[omeprazole]] | * [[omeprazole]] | ||
* [[Oncovin]] | * [[Oncovin]] | ||
* [[Onxol]] | * [[Onxol]] | ||
* [[oxaliplatin]] | * [[oxaliplatin]] | ||
* [[oxcarbazepine]] | * [[oxcarbazepine]] | ||
* [[Oxsoralen-Ultra]] | * [[Oxsoralen-Ultra]] | ||
* [[Pacerone]] | * [[Pacerone]] | ||
* [[paclitaxel]] | * [[paclitaxel]] | ||
* [[paclitaxel protein-bound]] | * [[paclitaxel protein-bound]] | ||
* [[pantoprazole]] | * [[pantoprazole]] | ||
* [[Paraplatin]] | * [[Paraplatin]] | ||
* [[Parlodel]] | * [[Parlodel]] | ||
* [[pectin]] | * [[pectin]] | ||
* [[Platinol-AQ]] | * [[Platinol-AQ]] | ||
* [[Plavix]] | * [[Plavix]] | ||
* [[Prevacid]] | * [[Prevacid]] | ||
* [[Prevacid I.V.]] | * [[Prevacid I.V.]] | ||
* [[Prevacid SoluTab]] | * [[Prevacid SoluTab]] | ||
* [[Prevalite]] | * [[Prevalite]] | ||
* [[Prezista]] | * [[Prezista]] | ||
* [[Priftin]] | * [[Priftin]] | ||
* [[Prilosec]] | * [[Prilosec]] | ||
* [[Prilosec OTC]] | * [[Prilosec OTC]] | ||
* [[Procardia]] | * [[Procardia]] | ||
* [[Procardia XL]] | * [[Procardia XL]] | ||
* [[Prograf]] | * [[Prograf]] | ||
* [[Protonix]] | * [[Protonix]] | ||
* [[Protonix IV]] | * [[Protonix IV]] | ||
* [[Protostat]] | * [[Protostat]] | ||
* [[Questran]] | * [[Questran]] | ||
* [[Questran Light]] | * [[Questran Light]] | ||
* [[Rapamune]] | * [[Rapamune]] | ||
* [[Raxar]] | * [[Raxar]] | ||
* [[Rebif]] | * [[Rebif]] | ||
* [[Rescriptor]] | * [[Rescriptor]] | ||
* [[Retrovir]] | * [[Retrovir]] | ||
* [[ReVia]] | * [[ReVia]] | ||
* [[Rheumatrex Dose Pack]] | * [[Rheumatrex Dose Pack]] | ||
* [[Rifadin]] | * [[Rifadin]] | ||
* [[Rifadin IV]] | * [[Rifadin IV]] | ||
* [[rifampin]] | * [[rifampin]] | ||
* [[rifapentine]] | * [[rifapentine]] | ||
* [[Rimactane]] | * [[Rimactane]] | ||
* [[RU-486]] | * [[RU-486]] | ||
* [[Sandostatin]] | * [[Sandostatin]] | ||
* [[Sandostatin LAR Depot]] | * [[Sandostatin LAR Depot]] | ||
* [[sirolimus]] | * [[sirolimus]] | ||
* [[Somatuline Depot]] | * [[Somatuline Depot]] | ||
* [[Sprycel]] | * [[Sprycel]] | ||
* [[St. John's wort]] | * [[St. John's wort]] | ||
* [[stavudine]] | * [[stavudine]] | ||
* [[stavudine extended release]] | * [[stavudine extended release]] | ||
* [[Sustiva]] | * [[Sustiva]] | ||
* [[tacrolimus]] | * [[tacrolimus]] | ||
* [[Tasigna]] | * [[Tasigna]] | ||
* [[Taxol]] | * [[Taxol]] | ||
* [[Taxotere]] | * [[Taxotere]] | ||
* [[Taztia XT]] | * [[Taztia XT]] | ||
* [[Tekturna]] | * [[Tekturna]] | ||
* [[telbivudine]] | * [[telbivudine]] | ||
* [[temsirolimus]] | * [[temsirolimus]] | ||
* [[thalidomide]] | * [[thalidomide]] | ||
* [[Thalomid]] | * [[Thalomid]] | ||
* [[thioguanine]] | * [[thioguanine]] | ||
* [[Tiazac]] | * [[Tiazac]] | ||
* [[Tindamax]] | * [[Tindamax]] | ||
* [[tinidazole]] | * [[tinidazole]] | ||
* [[Torisel]] | * [[Torisel]] | ||
* [[Tracleer]] | * [[Tracleer]] | ||
* [[Trexall]] | * [[Trexall]] | ||
* [[Trileptal]] | * [[Trileptal]] | ||
* [[Tykerb]] | * [[Tykerb]] | ||
* [[Tyzeka]] | * [[Tyzeka]] | ||
* [[Uvadex]] | * [[Uvadex]] | ||
* [[Velban]] | * [[Velban]] | ||
* [[Velcade]] | * [[Velcade]] | ||
* [[verapamil]] | * [[verapamil]] | ||
* [[verapamil 24 hour extended release]] | * [[verapamil 24 hour extended release]] | ||
* [[verapamil extended release]] | * [[verapamil extended release]] | ||
* [[Verelan]] | * [[Verelan]] | ||
* [[Verelan PM]] | * [[Verelan PM]] | ||
* [[Versed]] | * [[Versed]] | ||
* [[verteporfin]] | * [[verteporfin]] | ||
* [[VFEND]] | * [[VFEND]] | ||
* [[Videx]] | * [[Videx]] | ||
* [[Videx EC]] | * [[Videx EC]] | ||
* [[vinblastine]] | * [[vinblastine]] | ||
* [[Vincasar PFS]] | * [[Vincasar PFS]] | ||
* [[vincristine]] | * [[vincristine]] | ||
* [[vinorelbine]] | * [[vinorelbine]] | ||
* [[Viramune]] | * [[Viramune]] | ||
* [[Visudyne]] | * [[Visudyne]] | ||
* [[Vivitrol]] | * [[Vivitrol]] | ||
* [[voriconazole]] | * [[voriconazole]] | ||
* [[Yodoxin]] | * [[Yodoxin]] | ||
* [[Z-Pak]] | * [[Z-Pak]] | ||
* [[zafirlukast]] | * [[zafirlukast]] | ||
* [[zalcitabine]] | * [[zalcitabine]] | ||
* [[Zegerid (Original Formulation)]] | * [[Zegerid (Original Formulation)]] | ||
* [[Zerit]] | * [[Zerit]] | ||
* [[Zerit XR]] | * [[Zerit XR]] | ||
* [[Zetia]] | * [[Zetia]] | ||
* [[zidovudine]] | * [[zidovudine]] | ||
* [[Zithromax]] | * [[Zithromax]] | ||
* [[Zithromax IV]] | * [[Zithromax IV]] | ||
* [[Zithromax TRI-PAK]] | * [[Zithromax TRI-PAK]] | ||
* [[Zithromax Z-Pak]] | * [[Zithromax Z-Pak]] | ||
* [[Zmax]] | * [[Zmax]] | ||
{{refend}} | {{refend}} | ||
| Line 446: | Line 445: | ||
==Minor Interactions== | ==Minor Interactions== | ||
{{refbegin|3}} | {{refbegin|3}} | ||
* [[Adgyn Estro]] | * [[Adgyn Estro]] | ||
* [[Aerodiol]] | * [[Aerodiol]] | ||
* [[Aloh-Gel]] | * [[Aloh-Gel]] | ||
* [[Alora]] | * [[Alora]] | ||
* [[Alternagel]] | * [[Alternagel]] | ||
* [[Alu-Cap]] | * [[Alu-Cap]] | ||
* [[Alu-Tab]] | * [[Alu-Tab]] | ||
* [[aluminum hydroxide]] | * [[aluminum hydroxide]] | ||
* [[Amen]] | * [[Amen]] | ||
* [[Amphojel]] | * [[Amphojel]] | ||
* [[anisindione]] | * [[anisindione]] | ||
* [[Aquest]] | * [[Aquest]] | ||
* [[armodafinil]] | * [[armodafinil]] | ||
* [[Aygestin]] | * [[Aygestin]] | ||
* [[Bedol]] | * [[Bedol]] | ||
* [[bexarotene]] | * [[bexarotene]] | ||
* [[Camila]] | * [[Camila]] | ||
* [[Cenestin]] | * [[Cenestin]] | ||
* [[chlorotrianisene]] | * [[chlorotrianisene]] | ||
* [[Climara]] | * [[Climara]] | ||
* [[Climaval]] | * [[Climaval]] | ||
* [[Climodien]] | * [[Climodien]] | ||
* [[Clinagen LA 40]] | * [[Clinagen LA 40]] | ||
* [[Colestid]] | * [[Colestid]] | ||
* [[Colestid Flavored]] | * [[Colestid Flavored]] | ||
* [[colestipol]] | * [[colestipol]] | ||
* [[Concentrated Phillips Milk of Magnesia]] | * [[Concentrated Phillips Milk of Magnesia]] | ||
* [[conjugated estrogens]] | * [[conjugated estrogens]] | ||
* [[conjugated estrogens synthetic A]] | * [[conjugated estrogens synthetic A]] | ||
* [[conjugated estrogens synthetic B]] | * [[conjugated estrogens synthetic B]] | ||
* [[conjugated estrogens topical]] | * [[conjugated estrogens topical]] | ||
* [[Coumadin]] | * [[Coumadin]] | ||
* [[Crinone]] | * [[Crinone]] | ||
* [[Curretab]] | * [[Curretab]] | ||
* [[Cyclogest]] | * [[Cyclogest]] | ||
* [[Cycrin]] | * [[Cycrin]] | ||
* [[Delestrogen]] | * [[Delestrogen]] | ||
* [[DELIDOSE]] | * [[DELIDOSE]] | ||
* [[Delta-Lutin]] | * [[Delta-Lutin]] | ||
* [[Dep Gynogen]] | * [[Dep Gynogen]] | ||
* [[Depo-Estradiol]] | * [[Depo-Estradiol]] | ||
* [[Depo-Provera]] | * [[Depo-Provera]] | ||
* [[Depo-Provera Contraceptive]] | * [[Depo-Provera Contraceptive]] | ||
* [[depo-subQ provera 104]] | * [[depo-subQ provera 104]] | ||
* [[Depogen]] | * [[Depogen]] | ||
* [[Dermestril]] | * [[Dermestril]] | ||
* [[Dermestril - Septem]] | * [[Dermestril - Septem]] | ||
* [[Dermestril Septem]] | * [[Dermestril Septem]] | ||
* [[desogestrel]] | * [[desogestrel]] | ||
* [[Dialume]] | * [[Dialume]] | ||
* [[dicumarol]] | * [[dicumarol]] | ||
* [[dienestrol topical]] | * [[dienestrol topical]] | ||
* [[Dioval 40]] | * [[Dioval 40]] | ||
* [[Dioval XX]] | * [[Dioval XX]] | ||
* [[Divigel 0.25 mg/packet]] | * [[Divigel 0.25 mg/packet]] | ||
* [[Divigel 0.5 mg/packet]] | * [[Divigel 0.5 mg/packet]] | ||
* [[Divigel 1 mg/packet]] | * [[Divigel 1 mg/packet]] | ||
* [[drospirenone]] | * [[drospirenone]] | ||
* [[Dura-Estrin]] | * [[Dura-Estrin]] | ||
* [[Duragen]] | * [[Duragen]] | ||
* [[Duralutin]] | * [[Duralutin]] | ||
* [[Dynacirc]] | * [[Dynacirc]] | ||
* [[Dynacirc CR]] | * [[Dynacirc CR]] | ||
* [[Elestrin]] | * [[Elestrin]] | ||
* [[Elleste Solo]] | * [[Elleste Solo]] | ||
* [[Endometrin]] | * [[Endometrin]] | ||
* [[Enjuvia]] | * [[Enjuvia]] | ||
* [[Errin]] | * [[Errin]] | ||
* [[Esclim]] | * [[Esclim]] | ||
* [[esterified estrogens]] | * [[esterified estrogens]] | ||
* [[Estinyl]] | * [[Estinyl]] | ||
* [[Estra-C]] | * [[Estra-C]] | ||
* [[Estra-V 40]] | * [[Estra-V 40]] | ||
* [[Estrace]] | * [[Estrace]] | ||
* [[Estrace Vaginal Cream]] | * [[Estrace Vaginal Cream]] | ||
* [[Estraderm]] | * [[Estraderm]] | ||
* [[Estraderm MX]] | * [[Estraderm MX]] | ||
* [[Estraderm TTS]] | * [[Estraderm TTS]] | ||
* [[estradiol]] | * [[estradiol]] | ||
* [[estradiol acetate]] | * [[estradiol acetate]] | ||
* [[estradiol benzoate]] | * [[estradiol benzoate]] | ||
* [[estradiol cypionate]] | * [[estradiol cypionate]] | ||
* [[ESTRADIOL G GAM]] | * [[ESTRADIOL G GAM]] | ||
* [[Estradiol Patch]] | * [[Estradiol Patch]] | ||
* [[estradiol topical]] | * [[estradiol topical]] | ||
* [[estradiol valerate]] | * [[estradiol valerate]] | ||
* [[Estradot]] | * [[Estradot]] | ||
* [[Estradot 100]] | * [[Estradot 100]] | ||
* [[Estradot 37.5]] | * [[Estradot 37.5]] | ||
* [[Estradot 50]] | * [[Estradot 50]] | ||
* [[Estradot 75]] | * [[Estradot 75]] | ||
* [[Estragyn 5]] | * [[Estragyn 5]] | ||
* [[Estragyn LA 5]] | * [[Estragyn LA 5]] | ||
* [[ESTRAPATCH]] | * [[ESTRAPATCH]] | ||
* [[Estrasorb]] | * [[Estrasorb]] | ||
* [[ESTREVA]] | * [[ESTREVA]] | ||
* [[Estring]] | * [[Estring]] | ||
* [[Estro-A]] | * [[Estro-A]] | ||
* [[Estro-Cyp]] | * [[Estro-Cyp]] | ||
* [[Estro-L.A.]] | * [[Estro-L.A.]] | ||
* [[Estro-Span 40]] | * [[Estro-Span 40]] | ||
* [[Estrofem]] | * [[Estrofem]] | ||
* [[Estrogel]] | * [[Estrogel]] | ||
* [[estrone]] | * [[estrone]] | ||
* [[Estrone AQ]] | * [[Estrone AQ]] | ||
* [[estropipate]] | * [[estropipate]] | ||
* [[estropipate topical]] | * [[estropipate topical]] | ||
* [[ethinyl estradiol]] | * [[ethinyl estradiol]] | ||
* [[ethynodiol]] | * [[ethynodiol]] | ||
* [[etonogestrel]] | * [[etonogestrel]] | ||
* [[Evamist]] | * [[Evamist]] | ||
* [[Evorel]] | * [[Evorel]] | ||
* [[Ex-Lax Milk of Magnesia]] | * [[Ex-Lax Milk of Magnesia]] | ||
* [[Fematrix]] | * [[Fematrix]] | ||
* [[Fempatch]] | * [[Fempatch]] | ||
* [[Femring]] | * [[Femring]] | ||
* [[FEMSEPT]] | * [[FEMSEPT]] | ||
* [[FemSeven]] | * [[FemSeven]] | ||
* [[FemSeven Sequi Phase I]] | * [[FemSeven Sequi Phase I]] | ||
* [[FemTab]] | * [[FemTab]] | ||
* [[Femtrace]] | * [[Femtrace]] | ||
* [[Femtran]] | * [[Femtran]] | ||
* [[First Progesterone MC10]] | * [[First Progesterone MC10]] | ||
* [[First Progesterone MC5]] | * [[First Progesterone MC5]] | ||
* [[FIRST-Progesterone VGS 100]] | * [[FIRST-Progesterone VGS 100]] | ||
* [[FIRST-Progesterone VGS 200]] | * [[FIRST-Progesterone VGS 200]] | ||
* [[FIRST-Progesterone VGS 25]] | * [[FIRST-Progesterone VGS 25]] | ||
* [[FIRST-Progesterone VGS 400]] | * [[FIRST-Progesterone VGS 400]] | ||
* [[FIRST-Progesterone VGS 50]] | * [[FIRST-Progesterone VGS 50]] | ||
* [[Gestone]] | * [[Gestone]] | ||
* [[Gynodiol]] | * [[Gynodiol]] | ||
* [[Gynogen LA 20]] | * [[Gynogen LA 20]] | ||
* [[hydroxyprogesterone]] | * [[hydroxyprogesterone]] | ||
* [[Hylutin]] | * [[Hylutin]] | ||
* [[Hyprogesterone]] | * [[Hyprogesterone]] | ||
* [[Implanon]] | * [[Implanon]] | ||
* [[isradipine]] | * [[isradipine]] | ||
* [[isradipine extended release]] | * [[isradipine extended release]] | ||
* [[Jantoven]] | * [[Jantoven]] | ||
* [[Jolivette]] | * [[Jolivette]] | ||
* [[Kestrone 5]] | * [[Kestrone 5]] | ||
* [[levonorgestrel]] | * [[levonorgestrel]] | ||
* [[magnesium hydroxide]] | * [[magnesium hydroxide]] | ||
* [[Medidiol 10]] | * [[Medidiol 10]] | ||
* [[medroxyprogesterone]] | * [[medroxyprogesterone]] | ||
* [[Menaval-20]] | * [[Menaval-20]] | ||
* [[Menest]] | * [[Menest]] | ||
* [[Menopause Formula Progesterone]] | * [[Menopause Formula Progesterone]] | ||
* [[Menorest]] | * [[Menorest]] | ||
* [[Menorest Patch]] | * [[Menorest Patch]] | ||
* [[Menostar]] | * [[Menostar]] | ||
* [[mestranol]] | * [[mestranol]] | ||
* [[Mg hydroxide]] | * [[Mg hydroxide]] | ||
* [[Milk of Magnesia]] | * [[Milk of Magnesia]] | ||
* [[Miradon]] | * [[Miradon]] | ||
* [[Mirena]] | * [[Mirena]] | ||
* [[modafinil]] | * [[modafinil]] | ||
* [[Nor-QD]] | * [[Nor-QD]] | ||
* [[Nora-Be]] | * [[Nora-Be]] | ||
* [[norelgestromin]] | * [[norelgestromin]] | ||
* [[norethindrone]] | * [[norethindrone]] | ||
* [[norethindrone acetate]] | * [[norethindrone acetate]] | ||
* [[norethindrone topical]] | * [[norethindrone topical]] | ||
* [[norgestimate]] | * [[norgestimate]] | ||
* [[norgestrel]] | * [[norgestrel]] | ||
* [[Norplant System]] | * [[Norplant System]] | ||
* [[Nuvelle TS Phase I]] | * [[Nuvelle TS Phase I]] | ||
* [[Nuvigil]] | * [[Nuvigil]] | ||
* [[Oesclim]] | * [[Oesclim]] | ||
* [[Oestradiol]] | * [[Oestradiol]] | ||
* [[Oestradiol Implants]] | * [[Oestradiol Implants]] | ||
* [[Oestrodose]] | * [[Oestrodose]] | ||
* [[Oestrogel]] | * [[Oestrogel]] | ||
* [[Oestrogel Pump-Pack]] | * [[Oestrogel Pump-Pack]] | ||
* [[Ogen 0.625]] | * [[Ogen 0.625]] | ||
* [[Ogen 1.25]] | * [[Ogen 1.25]] | ||
* [[Ogen 2.5]] | * [[Ogen 2.5]] | ||
* [[Ogen Vaginal Cream]] | * [[Ogen Vaginal Cream]] | ||
* [[Organon Oestradiol]] | * [[Organon Oestradiol]] | ||
* [[Orion Progesterone]] | * [[Orion Progesterone]] | ||
* [[Oromone]] | * [[Oromone]] | ||
* [[Ortho Dienestrol]] | * [[Ortho Dienestrol]] | ||
* [[Ortho Micronor]] | * [[Ortho Micronor]] | ||
* [[Ortho-Est]] | * [[Ortho-Est]] | ||
* [[Ovrette]] | * [[Ovrette]] | ||
* [[Phillips Milk of Magnesia]] | * [[Phillips Milk of Magnesia]] | ||
* [[Plan B]] | * [[Plan B]] | ||
* [[Premarin]] | * [[Premarin]] | ||
* [[Premarin Intravenous]] | * [[Premarin Intravenous]] | ||
* [[Premarin Vaginal]] | * [[Premarin Vaginal]] | ||
* [[Primogyn Depot]] | * [[Primogyn Depot]] | ||
* [[Prochieve]] | * [[Prochieve]] | ||
* [[Prodrox]] | * [[Prodrox]] | ||
* [[Progest]] | * [[Progest]] | ||
* [[Progestasert System]] | * [[Progestasert System]] | ||
* [[progesterone]] | * [[progesterone]] | ||
* [[progesterone topical]] | * [[progesterone topical]] | ||
* [[Progynova]] | * [[Progynova]] | ||
* [[Progynova TS]] | * [[Progynova TS]] | ||
* [[Prometrium]] | * [[Prometrium]] | ||
* [[Provames]] | * [[Provames]] | ||
* [[Provera]] | * [[Provera]] | ||
* [[Provigil]] | * [[Provigil]] | ||
* [[quinestrol]] | * [[quinestrol]] | ||
* [[Sandrena]] | * [[Sandrena]] | ||
* [[Systen]] | * [[Systen]] | ||
* [[Tace]] | * [[Tace]] | ||
* [[Targretin]] | * [[Targretin]] | ||
* [[Thais]] | * [[Thais]] | ||
* [[Thaissept]] | * [[Thaissept]] | ||
* [[Vagifem]] | * [[Vagifem]] | ||
* [[Valergen]] | * [[Valergen]] | ||
* [[Vivelle]] | * [[Vivelle]] | ||
* [[Vivelle-Dot]] | * [[Vivelle-Dot]] | ||
* [[Vivelledot]] | * [[Vivelledot]] | ||
* [[Warfarin]] | * [[Warfarin]] | ||
* [[Zumenon]] | * [[Zumenon]] | ||
{{refend}} | {{refend}} | ||
==References== | ==References== | ||
Revision as of 00:28, 2 February 2014
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Pratik Bahekar, MBBS [2]
The risk of myopathy during treatment with statins is increased with concurrent administration of fibric acid derivatives, lipid-modifying doses of niacin, cyclosporine, or strong CYP 3A4 inhibitors (e.g., clarithromycin, HIV protease inhibitors, and itraconazole) [see Warnings and Precautions, Skeletal Muscle (5.1) and Clinical Pharmacology (12.3)].
Strong Inhibitors of CYP 3A4
Atorvastatin is metabolized by cytochrome P450 3A4. Concomitant administration of Atorvastatin with strong inhibitors of CYP 3A4 can lead to increases in plasma concentrations of atorvastatin. The extent of interaction and potentiation of effects depend on the variability of effect on CYP 3A4.
Clarithromycin
Atorvastatin AUC was significantly increased with concomitant administration of Atorvastatin 80 mg with clarithromycin (500 mg twice daily) compared to that of Atorvastatin alone [see Clinical Pharmacology (12.3)]. Therefore, in patients taking clarithromycin, caution should be used when the Atorvastatin dose exceeds 20 mg [see Warnings and Precautions, Skeletal Muscle (5.1) and Dosage and Administration (2.6)].
Combination of Protease Inhibitors
Atorvastatin AUC was significantly increased with concomitant administration of Atorvastatin with several combinations of HIV protease inhibitors, as well as with the hepatitis C protease inhibitor telaprevir, compared to that of Atorvastatin alone [see Clinical Pharmacology (12.3)]. Therefore, in patients taking the HIV protease inhibitor tipranavir plus ritonavir, or the hepatitis C protease inhibitor telaprevir, concomitant use of Atorvastatin should be avoided. In patients taking the HIV protease inhibitor lopinavir plus ritonavir, caution should be used when prescribing Atorvastatin and the lowest dose necessary should be used. In patients taking the HIV protease inhibitors saquinavir plus ritonavir, darunavir plus ritonavir, fosamprenavir, or fosamprenavir plus ritonavir, the dose of Atorvastatin should not exceed 20 mg and should be used with caution [see Warnings and Precautions, Skeletal Muscle (5.1) and Dosage and Administration (2.6)]. In patients taking the HIV protease inhibitor nelfinavir or the hepatitis C protease inhibitor boceprevir, the dose of Atorvastatin should not exceed 40 mg and close clinical monitoring is recommended.
Itraconazole
Atorvastatin AUC was significantly increased with concomitant administration of Atorvastatin 40 mg and itraconazole 200 mg [see Clinical Pharmacology (12.3)]. Therefore, in patients taking itraconazole, caution should be used when the Atorvastatin dose exceeds 20 mg [see Warnings and Precautions, Skeletal Muscle (5.1) and Dosage and Administration (2.6)].
Grapefruit Juice
Contains one or more components that inhibit CYP 3A4 and can increase plasma concentrations of atorvastatin, especially with excessive grapefruit juice consumption (>1.2 liters per day).
Cyclosporine
Atorvastatin and atorvastatin-metabolites are substrates of the OATP1B1 transporter. Inhibitors of the OATP1B1 (e.g., cyclosporine) can increase the bioavailability of atorvastatin. Atorvastatin AUC was significantly increased with concomitant administration of Atorvastatin 10 mg and cyclosporine 5.2 mg/kg/day compared to that of Atorvastatin alone [see Clinical Pharmacology (12.3)]. The co-administration of Atorvastatin with cyclosporine should be avoided [see Warnings and Precautions, Skeletal Muscle (5.1)].
Gemfibrozil
Due to an increased risk of myopathy/rhabdomyolysis when HMG-CoA reductase inhibitors are co-administered with gemfibrozil, concomitant administration of Atorvastatin with gemfibrozil should be avoided [see Warnings and Precautions (5.1)].
Other Fibrates
Because it is known that the risk of myopathy during treatment with HMG-CoA reductase inhibitors is increased with concurrent administration of other fibrates, Atorvastatin should be administered with caution when used concomitantly with other fibrates [see Warnings and Precautions (5.1)].
Niacin
The risk of skeletal muscle effects may be enhanced when Atorvastatin is used in combination with niacin; a reduction in Atorvastatin dosage should be considered in this setting [see Warnings and Precautions (5.1)].
Rifampin or other Inducers of Cytochrome P450 3A4
Concomitant administration of Atorvastatin with inducers of cytochrome P450 3A4 (e.g., efavirenz, rifampin) can lead to variable reductions in plasma concentrations of atorvastatin. Due to the dual interaction mechanism of rifampin, simultaneous co-administration of Atorvastatin with rifampin is recommended, as delayed administration of Atorvastatin after administration of rifampin has been associated with a significant reduction in atorvastatin plasma concentrations.
Digoxin
When multiple doses of Atorvastatin and digoxin were co-administered, steady state plasma digoxin concentrations increased by approximately 20%. Patients taking digoxin should be monitored appropriately.
Oral Contraceptives
Co-administration of Atorvastatin and an oral contraceptive increased AUC values for norethindrone and ethinyl estradiol [see Clinical Pharmacology (12.3)]. These increases should be considered when selecting an oral contraceptive for a woman taking Atorvastatin.
Warfarin
Atorvastatin had no clinically significant effect on prothrombin time when administered to patients receiving chronic warfarin treatment.
Colchicine
Cases of myopathy, including rhabdomyolysis, have been reported with atorvastatin co-administered with colchicine, and caution should be exercised when prescribing atorvastatin with colchicine.[1]
Major Interactions
- Agenerase
- amprenavir
- Antara
- Aptivus
- atazanavir
- Atromid-S
- B-3-50
- B3-500-Gr
- Biaxin
- Biaxin XL
- Biaxin XL-Pak
- clarithromycin
- clarithromycin extended release
- clofibrate
- clotrimazole
- conivaptan
- Crixivan
- cyclosporine
- danazol
- Danocrine
- Diflucan
- Dom-Fenofibrate
- E-Mycin
- E.E.S. Granules
- E.E.S.-200
- E.E.S.-400
- E.E.S.-400 Filmtab
- Ery-Tab
- Eryc
- EryPed
- EryPed 200
- EryPed 400
- Erythrocin Lactobionate
- Erythrocin Stearate Filmtab
- Erythrocot
- erythromycin
- erythromycin base
- erythromycin estolate
- erythromycin ethylsuccinate
- erythromycin lactobionate
- erythromycin stearate
- fenofibrate
- Fenoglide
- fluconazole
- Fortovase
- fosamprenavir
- gemfibrozil
- Gengraf
- Ilosone
- Ilotycin Gluceptate
- indinavir
- Invirase
- itraconazole
- Ketek
- Ketek Pak
- ketoconazole
- Lexiva
- Lipidil EZ
- Lipidil Micro
- Lipidil Supra
- Lipofen
- Lofibra
- Lopid
- mibefradil
- miconazole
- Monistat I.V.
- MY-E
- Mycelex Troche
- nefazodone
- nelfinavir
- Neoral
- niacin
- niacin extended release
- Niacin SR
- Niacor
- Niacor B3
- Niaspan ER
- Niaspan ER Starter Pack
- Nico-400
- Nicobid Tempules
- Nicolar
- Nicotinex
- Nicotinic Acid
- Nizoral
- Norvir
- Norvir Soft Gelatin
- Noxafil
- PCE Dispertab
- posaconazole
- Posicor
- Reyataz
- ritonavir
- Robimycin
- Sandimmune
- saquinavir
- saquinavir mesylate
- Serzone
- Slo-Niacin
- Sporanox
- Tao
- telithromycin
- Telzir
- tipranavir
- TriCor
- Triglide
- troleandomycin
- Vaprisol
- Viracept
- vitamin B3
Moderate Interactions
- 8-Mop
- Abraxane
- Accolate
- Adalat
- Adalat CC
- Afeditab CR
- aliskiren
- aminolevulinic acid topical
- amiodarone
- Antabuse
- aprepitant
- Arava
- Arranon
- Avonex
- Avonex Prefilled Syringe
- azithromycin
- Azithromycin 3 Day Dose Pack
- Azithromycin 5 Day Dose Pack
- azithromycin extended release
- AZT
- Betaseron
- bortezomib
- bosentan
- bromocriptine
- Calan
- Calan SR
- carboplatin
- Carboplatin Novaplus
- Cardizem
- Cardizem CD
- Cardizem LA
- Cardizem Monovial
- Cardizem SR
- Cardoxin
- Cartia XT
- Chloracol
- chloramphenicol
- Chloromycetin
- Chloromycetin Sodium Succinate
- cholestyramine
- Cholestyramine Light
- cisplatin
- clofarabine
- Clolar
- clopidogrel
- Cordarone
- Cordarone I.V.
- Covera-HS
- Cubicin
- D.H.E. 45
- d4T
- dalfopristin
- daptomycin
- darunavir
- dasatinib
- ddC
- ddI
- delavirdine
- didanosine
- didanosine delayed release capsule
- Digitek
- digoxin
- digoxin capsule
- dihydroergotamine
- dihydroergotamine nasal
- Dilacor XR
- Diltia XT
- diltiazem
- diltiazem 24 hour extended release
- diltiazem extended release
- Diltiazem Hydrochloride CD
- Diltiazem Hydrochloride SR
- Diltiazem Hydrochloride XR
- Diltiazem Hydrochloride XT
- Diquinol
- disulfiram
- docetaxel
- echinacea
- efavirenz
- Eloxatin
- Emend
- Emend 3-Day
- Emend for Injection
- Ergomar
- ergotamine
- esomeprazole
- etravirine
- ezetimibe
- Fasigyn
- FK506
- Flagyl
- Flagyl 375
- Flagyl ER
- Flagyl I.V.
- Flagyl I.V. RTU
- fluvoxamine
- fluvoxamine extended release
- Folex PFS
- fosaprepitant
- Furadantin
- Gleevec
- goldenseal
- grepafloxacin
- Hivid
- hypericum perforatum
- imatinib
- INH
- Intelence
- interferon beta-1a
- interferon beta-1b
- iodoquinol
- isoniazid
- Isoptin
- Isoptin I.V.
- Isoptin SR
- ixabepilone
- Ixempra
- Lanoxicaps
- Lanoxin
- lanreotide
- lansoprazole
- lapatinib
- leflunomide
- Levulan Kerastick
- Luvox
- Luvox CR
- Macrobid
- Macrodantin
- methotrexate
- Methotrexate Sodium Preservative Free
- methoxsalen
- Metro I.V.
- metronidazole
- metronidazole extended release
- Metryl
- midazolam
- Mifeprex
- mifepristone
- Migranal
- naltrexone
- Navelbine
- nelarabine
- nevirapine
- Nexium
- Nexium I.V.
- Nifediac CC
- Nifedical XL
- Nifedipine
- Nifedipine extended release
- nilotinib
- Nitro Macro
- nitrofurantoin
- nitrofurantoin dual release
- nitrofurantoin macrocrystals
- nitrofurantoin regular release
- Nydrazid
- octreotide
- omeprazole
- Oncovin
- Onxol
- oxaliplatin
- oxcarbazepine
- Oxsoralen-Ultra
- Pacerone
- paclitaxel
- paclitaxel protein-bound
- pantoprazole
- Paraplatin
- Parlodel
- pectin
- Platinol-AQ
- Plavix
- Prevacid
- Prevacid I.V.
- Prevacid SoluTab
- Prevalite
- Prezista
- Priftin
- Prilosec
- Prilosec OTC
- Procardia
- Procardia XL
- Prograf
- Protonix
- Protonix IV
- Protostat
- Questran
- Questran Light
- Rapamune
- Raxar
- Rebif
- Rescriptor
- Retrovir
- ReVia
- Rheumatrex Dose Pack
- Rifadin
- Rifadin IV
- rifampin
- rifapentine
- Rimactane
- RU-486
- Sandostatin
- Sandostatin LAR Depot
- sirolimus
- Somatuline Depot
- Sprycel
- St. John's wort
- stavudine
- stavudine extended release
- Sustiva
- tacrolimus
- Tasigna
- Taxol
- Taxotere
- Taztia XT
- Tekturna
- telbivudine
- temsirolimus
- thalidomide
- Thalomid
- thioguanine
- Tiazac
- Tindamax
- tinidazole
- Torisel
- Tracleer
- Trexall
- Trileptal
- Tykerb
- Tyzeka
- Uvadex
- Velban
- Velcade
- verapamil
- verapamil 24 hour extended release
- verapamil extended release
- Verelan
- Verelan PM
- Versed
- verteporfin
- VFEND
- Videx
- Videx EC
- vinblastine
- Vincasar PFS
- vincristine
- vinorelbine
- Viramune
- Visudyne
- Vivitrol
- voriconazole
- Yodoxin
- Z-Pak
- zafirlukast
- zalcitabine
- Zegerid (Original Formulation)
- Zerit
- Zerit XR
- Zetia
- zidovudine
- Zithromax
- Zithromax IV
- Zithromax TRI-PAK
- Zithromax Z-Pak
- Zmax
Minor Interactions
- Adgyn Estro
- Aerodiol
- Aloh-Gel
- Alora
- Alternagel
- Alu-Cap
- Alu-Tab
- aluminum hydroxide
- Amen
- Amphojel
- anisindione
- Aquest
- armodafinil
- Aygestin
- Bedol
- bexarotene
- Camila
- Cenestin
- chlorotrianisene
- Climara
- Climaval
- Climodien
- Clinagen LA 40
- Colestid
- Colestid Flavored
- colestipol
- Concentrated Phillips Milk of Magnesia
- conjugated estrogens
- conjugated estrogens synthetic A
- conjugated estrogens synthetic B
- conjugated estrogens topical
- Coumadin
- Crinone
- Curretab
- Cyclogest
- Cycrin
- Delestrogen
- DELIDOSE
- Delta-Lutin
- Dep Gynogen
- Depo-Estradiol
- Depo-Provera
- Depo-Provera Contraceptive
- depo-subQ provera 104
- Depogen
- Dermestril
- Dermestril - Septem
- Dermestril Septem
- desogestrel
- Dialume
- dicumarol
- dienestrol topical
- Dioval 40
- Dioval XX
- Divigel 0.25 mg/packet
- Divigel 0.5 mg/packet
- Divigel 1 mg/packet
- drospirenone
- Dura-Estrin
- Duragen
- Duralutin
- Dynacirc
- Dynacirc CR
- Elestrin
- Elleste Solo
- Endometrin
- Enjuvia
- Errin
- Esclim
- esterified estrogens
- Estinyl
- Estra-C
- Estra-V 40
- Estrace
- Estrace Vaginal Cream
- Estraderm
- Estraderm MX
- Estraderm TTS
- estradiol
- estradiol acetate
- estradiol benzoate
- estradiol cypionate
- ESTRADIOL G GAM
- Estradiol Patch
- estradiol topical
- estradiol valerate
- Estradot
- Estradot 100
- Estradot 37.5
- Estradot 50
- Estradot 75
- Estragyn 5
- Estragyn LA 5
- ESTRAPATCH
- Estrasorb
- ESTREVA
- Estring
- Estro-A
- Estro-Cyp
- Estro-L.A.
- Estro-Span 40
- Estrofem
- Estrogel
- estrone
- Estrone AQ
- estropipate
- estropipate topical
- ethinyl estradiol
- ethynodiol
- etonogestrel
- Evamist
- Evorel
- Ex-Lax Milk of Magnesia
- Fematrix
- Fempatch
- Femring
- FEMSEPT
- FemSeven
- FemSeven Sequi Phase I
- FemTab
- Femtrace
- Femtran
- First Progesterone MC10
- First Progesterone MC5
- FIRST-Progesterone VGS 100
- FIRST-Progesterone VGS 200
- FIRST-Progesterone VGS 25
- FIRST-Progesterone VGS 400
- FIRST-Progesterone VGS 50
- Gestone
- Gynodiol
- Gynogen LA 20
- hydroxyprogesterone
- Hylutin
- Hyprogesterone
- Implanon
- isradipine
- isradipine extended release
- Jantoven
- Jolivette
- Kestrone 5
- levonorgestrel
- magnesium hydroxide
- Medidiol 10
- medroxyprogesterone
- Menaval-20
- Menest
- Menopause Formula Progesterone
- Menorest
- Menorest Patch
- Menostar
- mestranol
- Mg hydroxide
- Milk of Magnesia
- Miradon
- Mirena
- modafinil
- Nor-QD
- Nora-Be
- norelgestromin
- norethindrone
- norethindrone acetate
- norethindrone topical
- norgestimate
- norgestrel
- Norplant System
- Nuvelle TS Phase I
- Nuvigil
- Oesclim
- Oestradiol
- Oestradiol Implants
- Oestrodose
- Oestrogel
- Oestrogel Pump-Pack
- Ogen 0.625
- Ogen 1.25
- Ogen 2.5
- Ogen Vaginal Cream
- Organon Oestradiol
- Orion Progesterone
- Oromone
- Ortho Dienestrol
- Ortho Micronor
- Ortho-Est
- Ovrette
- Phillips Milk of Magnesia
- Plan B
- Premarin
- Premarin Intravenous
- Premarin Vaginal
- Primogyn Depot
- Prochieve
- Prodrox
- Progest
- Progestasert System
- progesterone
- progesterone topical
- Progynova
- Progynova TS
- Prometrium
- Provames
- Provera
- Provigil
- quinestrol
- Sandrena
- Systen
- Tace
- Targretin
- Thais
- Thaissept
- Vagifem
- Valergen
- Vivelle
- Vivelle-Dot
- Vivelledot
- Warfarin
- Zumenon
References
Adapted from the FDA Package Insert.