Atenolol description: Difference between revisions
(Created page with "__NOTOC__ {{Atenolol}} {{CMG}}; {{AE}} {{SS}} ==Description== TENORMIN® (atenolol), a synthetic, beta1-selective (cardioselective) adrenoreceptor blocking agent, may be chem...") |
Gerald Chi (talk | contribs) mNo edit summary |
||
| Line 5: | Line 5: | ||
==Description== | ==Description== | ||
TENORMIN® (atenolol), a synthetic, beta1-selective (cardioselective) adrenoreceptor blocking agent, may be chemically described as benzeneacetamide, 4 -[2'-hydroxy-3'-[(1- methylethyl) amino] propoxy]-. The molecular and structural formulas are: | TENORMIN® (atenolol), a synthetic, beta1-selective (cardioselective) adrenoreceptor blocking agent, may be chemically described as benzeneacetamide, 4 -[2'-hydroxy-3'-[(1- methylethyl) amino] propoxy]-. The molecular and structural formulas are: | ||
{| | {| | ||
|[[File:Atenolol05.jpg|thumb|800px]] | |[[File:Atenolol05.jpg|thumb|800px]] | ||
|} | |} | ||
Atenolol (free base) has a molecular weight of 266. It is a relatively polar hydrophilic compound with a water solubility of 26.5 mg/mL at 37°C and a log partition coefficient (octanol/water) of 0.23. It is freely soluble in 1N HCl (300 mg/mL at 25°C) and less soluble in chloroform (3 mg/mL at 25°C). | Atenolol (free base) has a molecular weight of 266. It is a relatively polar hydrophilic compound with a water solubility of 26.5 mg/mL at 37°C and a log partition coefficient (octanol/water) of 0.23. It is freely soluble in 1N HCl (300 mg/mL at 25°C) and less soluble in chloroform (3 mg/mL at 25°C). | ||
TENORMIN is available as 25, 50 and 100 mg tablets for oral administration. | TENORMIN is available as 25, 50 and 100 mg tablets for oral administration. | ||
Inactive Ingredients: Magnesium stearate, microcrystalline cellulose, povidone, sodium starch glycolate. | Inactive Ingredients: Magnesium stearate, microcrystalline cellulose, povidone, sodium starch glycolate.<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = TENORMIN (ATENOLOL) TABLET [ASTRAZENECA PHARMACEUTICALS LP] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=fcfc9676-4edc-460e-6199-8161b824908f | publisher = | date = | accessdate = 5 February 2014 }}</ref> | ||
<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = TENORMIN (ATENOLOL) TABLET [ASTRAZENECA PHARMACEUTICALS LP] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=fcfc9676-4edc-460e-6199-8161b824908f | publisher = | date = | accessdate = 5 February 2014 }}</ref> | |||
==References== | ==References== | ||
| Line 28: | Line 21: | ||
[[Category:Beta blockers]] | [[Category:Beta blockers]] | ||
[[Category:Cardiovascular Drugs]] | [[Category:Cardiovascular Drugs]] | ||
[[Category:Drugs]] | [[Category:Drugs]] | ||
{{WikiDoc Help Menu}} | {{WikiDoc Help Menu}} | ||
{{WikiDoc Sources}} | {{WikiDoc Sources}} | ||
Revision as of 02:38, 10 February 2014
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sheng Shi, M.D. [2]
Description
TENORMIN® (atenolol), a synthetic, beta1-selective (cardioselective) adrenoreceptor blocking agent, may be chemically described as benzeneacetamide, 4 -[2'-hydroxy-3'-[(1- methylethyl) amino] propoxy]-. The molecular and structural formulas are:
 |
Atenolol (free base) has a molecular weight of 266. It is a relatively polar hydrophilic compound with a water solubility of 26.5 mg/mL at 37°C and a log partition coefficient (octanol/water) of 0.23. It is freely soluble in 1N HCl (300 mg/mL at 25°C) and less soluble in chloroform (3 mg/mL at 25°C).
TENORMIN is available as 25, 50 and 100 mg tablets for oral administration.
Inactive Ingredients: Magnesium stearate, microcrystalline cellulose, povidone, sodium starch glycolate.[1]
References
- ↑ "TENORMIN (ATENOLOL) TABLET [ASTRAZENECA PHARMACEUTICALS LP]". Retrieved 5 February 2014.