|
|
| Line 1: |
Line 1: |
| __NOTOC__
| | #REDIRECT [[Clonidine#Drug Interactions]] |
| {{Clonidine}}
| |
| {{CMG}}; {{AE}} {{PB}}
| |
| | |
| '''''For patient information, click [[Clonidine (patient information)|here]]'''''.
| |
| | |
| ==Drug Interactions==
| |
| Clonidine may potentiate the CNS-depressive effects of alcohol, [[barbiturates]] or other sedating drugs. If a patient receiving clonidine hydrochloride is also taking [[tricyclic]] antidepressants, the [[hypotensive]] effect of clonidine may be reduced, necessitating an increase in the clonidine dose. If a patient receiving clonidine is also taking [[neuroleptics]], orthostatic regulation disturbances (e.g., [[orthostatic hypotension]], dizziness, fatigue) may be induced or exacerbated.
| |
| | |
| Monitor heart rate in patients receiving clonidine concomitantly with agents known to affect sinus node function or AV nodal conduction, e.g., [[digitalis]], [[calcium channel blockers]] and [[beta-blockers]]. Sinus [[bradycardia]] resulting in hospitalization and [[pacemaker]] insertion has been reported in association with the use of clonidine concomitantly with [[diltiazem]] or [[verapamil]].
| |
| | |
| [[Amitriptyline]] in combination with clonidine enhances the manifestation of corneal lesions in rats (see Toxicology).
| |
| | |
| Based on observations in patients in a state of alcoholic delirium it has been suggested that high intravenous doses of clonidine may increase the arrhythmogenic potential (QT-prolongation, [[ventricular fibrillation]]) of high intravenous doses of [[haloperidol]]. Causal relationship and relevance for clonidine oral tablets have not been established.<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = CATAPRES (CLONIDINE HYDROCHLORIDE) TABLET [BOEHRINGER INGELHEIM PHARMACEUTICALS INC.] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=d7f569dc-6bed-42dc-9bec-940a9e6b090d | publisher = | date = | accessdate = 5 February 2014 }}</ref>
| |
| | |
| ==References==
| |
| | |
| {{Reflist|2}}
| |
| | |
| {{Antimigraine preparations}}
| |
|
| |
|
| | [[Category:Cardiovascular Drugs]] |
| [[Category:Drugs]] | | [[Category:Drugs]] |