Topiramate warnings and precautions: Difference between revisions
Jump to navigation
Jump to search
Created page with "__NOTOC__ {{Topiramate}} {{CMG}}; {{AE}} {{PB}} '''''For patient information, click here'''''. ==Warnings and Precautions== <ref nam..." |
|||
| Line 7: | Line 7: | ||
==Warnings and Precautions== | ==Warnings and Precautions== | ||
* Acute myopia and secondary angle closure glaucoma: Untreated elevated intraocular pressure can lead to permanent visual loss. The primary treatment to reverse symptoms is discontinuation of topiramate as rapidly as possible. | |||
* Oligohidrosis and hyperthermia: Monitor decreased sweating and increased body temperature, especially in pediatric patients . | |||
Metabolic acidosis: Baseline and periodic measurement of serum bicarbonate is recommended. Consider dose reduction or discontinuation of topiramate if clinically appropriate. | |||
* Suicidal behavior and ideation: Antiepileptic drugs increase the risk of suicidal behavior or ideation. | |||
* Cognitive/neuropsychiatric: Topiramate may cause cognitive dysfunction. Patients should use caution when operating machinery including automobiles. Depression and mood problems may occur in epilepsy and other populations. | |||
* Fetal Toxicity: Topiramate use during pregnancy can cause cleft lip and/or palate . | |||
* Withdrawal of AEDs: Withdrawal of topiramate should be done gradually . | |||
* Hyperammonemia and encephalopathy associated with or without concomitant valproic acid use: Patients with inborn errors of metabolism or reduced mitochondrial activity may have an increased risk of hyperammonemia. Measure ammonia if encephalopathic symptoms occur. | |||
* Kidney stones: Use with other carbonic anhydrase inhibitors, other drugs causing metabolic acidosis, or in patients on a ketogenic diet should be avoided (5.10). | |||
* Hypothermia has been reported with and without hyperammonemia during topiramate treatment with concomitant valproic acid use.<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = TOPIRAMATE (TOPIRAMATE ) TABLET, FILM COATED [AUROBINDO PHARMA LIMITED] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=32b48ea0-a215-43b8-83b4-a5435a686d68 | publisher = | date = | accessdate = 6 February 2014 }}</ref> | |||
==References== | ==References== | ||
Revision as of 23:07, 6 February 2014
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Pratik Bahekar, MBBS [2]
For patient information, click here.
Warnings and Precautions
- Acute myopia and secondary angle closure glaucoma: Untreated elevated intraocular pressure can lead to permanent visual loss. The primary treatment to reverse symptoms is discontinuation of topiramate as rapidly as possible.
- Oligohidrosis and hyperthermia: Monitor decreased sweating and increased body temperature, especially in pediatric patients .
Metabolic acidosis: Baseline and periodic measurement of serum bicarbonate is recommended. Consider dose reduction or discontinuation of topiramate if clinically appropriate.
- Suicidal behavior and ideation: Antiepileptic drugs increase the risk of suicidal behavior or ideation.
- Cognitive/neuropsychiatric: Topiramate may cause cognitive dysfunction. Patients should use caution when operating machinery including automobiles. Depression and mood problems may occur in epilepsy and other populations.
- Fetal Toxicity: Topiramate use during pregnancy can cause cleft lip and/or palate .
- Withdrawal of AEDs: Withdrawal of topiramate should be done gradually .
- Hyperammonemia and encephalopathy associated with or without concomitant valproic acid use: Patients with inborn errors of metabolism or reduced mitochondrial activity may have an increased risk of hyperammonemia. Measure ammonia if encephalopathic symptoms occur.
- Kidney stones: Use with other carbonic anhydrase inhibitors, other drugs causing metabolic acidosis, or in patients on a ketogenic diet should be avoided (5.10).
- Hypothermia has been reported with and without hyperammonemia during topiramate treatment with concomitant valproic acid use.[1]
References
- ↑ "TOPIRAMATE (TOPIRAMATE ) TABLET, FILM COATED [AUROBINDO PHARMA LIMITED]". Retrieved 6 February 2014.