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| __NOTOC__
| | #REDIRECT [[Cholestyramine]] |
| {{Cholestyramine}}
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| {{CMG}}; {{AE}} {{SS}}
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| ==Indications and Usage==
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| 1) Prevalite® is indicated as adjunctive therapy to diet for the reduction of elevated serum cholesterol in patients with primary [[hypercholesterolemia]] (elevated low-density lipoprotein [LDL] cholesterol) who do not respond adequately to diet. Prevalite® may be useful to lower LDL cholesterol in patients who also have [[hypertriglyceridemia]], but it is not indicated where [[hypertriglyceridemia]] is the abnormality of most concern.
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| Therapy with lipid-altering agents should be a component of multiple risk factor intervention in those individuals at significantly increased risk for atherosclerotic vascular disease due to [[hypercholesterolemia]]. Treatment should begin and continue with dietary therapy specific for the type of [[hyperlipoproteinemia]] determined prior to initiation of drug therapy. Excess body weight may be an important factor and caloric restriction for weight normalization should be addressed prior to drug therapy in the overweight.
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| Prior to initiating therapy with cholestyramine resin, secondary causes of [[hypercholesterolemia]] (e.g., poorly controlled [[diabetes mellitus]], [[hypothyroidism]], [[nephrotic syndrome]], [[dysproteinemias]], obstructive liver disease, other drug therapy, alcoholism), should be excluded, and a lipid profile performed to assess total cholesterol (Total-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides (TG). For individuals with TG less than 400 mg/dL (<4.5 mmol/L), LDL-C can be estimated using the following equation:
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| LDL-C = Total Cholesterol - [(TG/5) + HDL-C]
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| For TG levels >400 mg/dL, this equation is less accurate and LDL-C concentrations should be determined by ultracentrifugation. In [[hypertriglyceridemic]]patients, LDL-C may be low or normal despite elevated Total-C. In such cases cholestyramine resin may not be indicated.
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| Serum cholesterol and triglyceride levels should be determined periodically based on NCEP guidelines to confirm initial and adequate long-term response. A favorable trend in cholesterol reduction should occur during the first month of cholestyramine resin therapy. The therapy should be continued to sustain cholesterol reduction. If adequate cholesterol reduction is not attained, increasing the dosage of cholestyramine resin or adding other lipid-lowering agents in combination with cholestyramine resin should be considered.
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| Since the goal of treatment is to lower LDL-C, the NCEP4 recommends that LDL-C levels be used to initiate and assess treatment response. If LDL-C levels are not available then Total-C alone may be used to monitor long-term therapy. A lipoprotein analysis (including LDL-C determination) should be carried out once a year. The NCEP treatment guidelines are summarized below.
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| |[[File:Cholestyramine01.jpg|thumb|800px]]
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| Cholestyramine resin monotherapy has been demonstrated to retard the rate of progression2,3 and increase the rate of regression3 of coronary atherosclerosis.
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| 2) Prevalite® is indicated for the relief of pruritus associated with partial biliary obstruction. Cholestyramine resin has been shown to have a variable effect on serum cholesterol in these patients. Patients with primary biliary cirrhosis may exhibit an elevated cholesterol as part of their disease.<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = PREVALITE (CHOLESTYRAMINE) POWDER, FOR SUSPENSION [UPSHER-SMITH LABORATORIES INC.] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=dd434ef8-8af3-434c-a0a0-9a0b18459ba0 | publisher = | date = | accessdate = 10 February 2014 }}</ref>
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| ==References==
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| {{Reflist|2}}
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| {{Lipid modifying agents}}
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| [[Category:Hepatology]]
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| [[Category:Bile acid sequestrants]]
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| [[Category:Cardiovasuclar Drugs]]
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| [[Category:Drugs]]
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